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Protein

Catalase-peroxidase

Gene

katG

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei107 – 1071Transition state stabilizerUniRule annotation
Active sitei111 – 1111Proton acceptorUniRule annotation
Metal bindingi274 – 2741Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:MUL_2190
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000765 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Catalase-peroxidasePRO_0000354845Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki110 ↔ 233Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-259)UniRule annotation
Cross-linki233 ↔ 259Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-110)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PQH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDSRPPQP DTSTQSNSES ESPAISSPTP QDHAPMTNRD WWPNQIDVSM
60 70 80 90 100
LHPHPSQASP LGADFDYPKE FAKLDVDALK ADVMSVMTTS QDWWPADYGH
110 120 130 140 150
YGGLFIRMSW HAAGTYRIQD GRGGGGQGMQ RFAPLNSWPD NVSLDKARRL
160 170 180 190 200
LWPVKQKYGS EISWADLIIF AGNCALDSMG FKTFGFGFGR EDVWQPEEVM
210 220 230 240 250
WGEEDVWLGT DKRYSGKRDL AQPYGATTMG LIYVNPEGPE GKPDPVAAAH
260 270 280 290 300
DIRETFARMA MNDEETAALI VGGHSFGKTH GAGDADLVGP EPEAAPIEQQ
310 320 330 340 350
GFGWKSSFGS GKGKDAITSG LEVVWTPTPT QWGNGFLELL YGYEWELTKS
360 370 380 390 400
PAGAWQFTAK DGAGAGTIPD PFGGPGRAPT MLVTDISMRE DPIYRRITQR
410 420 430 440 450
WLEHPEELTE AFAKAWYKLL HRDMGPVSRY LGPWVAEPQL WQDPVPDVDH
460 470 480 490 500
ELVDAKDVAA LKSKVLASGL TVAQLVKTAW SAASSFRRTD KRGGANGGRL
510 520 530 540 550
RLEPQKSWES NEPADLDQVL SVLEGIQQDF NSSAAGGKKI SLADLIVLAG
560 570 580 590 600
SAAVEKAAKD GGHEVSVPFS PGRTDASQEN TDVESFAVLE PRADGFRNYV
610 620 630 640 650
RVGEKAPLEH LLIERAYRLG VTAPEMTVLV GGLRALGANH GGSEHGVFTD
660 670 680 690 700
KPGVLSNDFF VNLLDMGTEW KASDAAENVY EGCDRSSGQL KWTATANDLV
710 720 730 740
FGSNSVLRAL AEVYAQSDAK QKFAEDFAAA WAKVMNNDRF DLE
Length:743
Mass (Da):81,050
Last modified:November 25, 2008 - v2
Checksum:iF9C95BB473BE258F
GO

Sequence cautioni

The sequence ABL04595.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL04595.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABL04595; ABL04595; MUL_2190.
KEGGimul:MUL_2190.
PATRICi18171495. VBIMycUlc37413_2591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL04595.1. Different initiation.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL04595; ABL04595; MUL_2190.
KEGGimul:MUL_2190.
PATRICi18171495. VBIMycUlc37413_2591.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
    Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
    , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
    Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Agy99.

Entry informationi

Entry nameiKATG_MYCUA
AccessioniPrimary (citable) accession number: A0PQH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: February 17, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.