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A0PQH1 (A0PQH1_MYCUA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Dihydrodipicolinate synthase DapA EMBL ABL04590.1
Gene names
Name:dapA EMBL ABL04590.1
Ordered Locus Names:MUL_2184
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. SAAS SAAS005263

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. SAAS SAAS005263

Subcellular location

Cytoplasm By similarity SAAS SAAS005263.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis SAAS SAAS005263
Lysine biosynthesis SAAS SAAS005263
   Cellular componentCytoplasm SAAS SAAS005263
   LigandSchiff base SAAS SAAS005263
   Molecular functionLyase SAAS SAAS005263
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A0PQH1 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 73D03F764F664192

FASTA30030,738
        10         20         30         40         50         60 
MSTVGFDVPA RLGTLLTAMV TPFGSDGALD LAAAARLANH LVDQGCDGLV VSGTTGESPT 

        70         80         90        100        110        120 
TTDDEKRELL RVVLEAVGDR ARVIAGAGTN DTAHSIGLAK AAAAEGAHGL LVVTPYYSKP 

       130        140        150        160        170        180 
PQSGLLAHFT AVADATELPV LLYDIPGRSA VPIESETIRA LAKHPNIVGV KDAKADLPSG 

       190        200        210        220        230        240 
AQIMADTGLA YYSGDDALNL PWLAMGAIGF ISVIGHLAAG QLREMLSAFS SGDVATARKI 

       250        260        270        280        290        300 
NVAVSPLCNA MTRLGGVTLS KAGLRLQGIE VGDPRLPQVA ATAEQIDVLA ADMRAASVLR

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References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL04590.1.
RefSeqYP_906061.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PQH1.
SMRA0PQH1. Positions 5-300.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PQH1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000075475; EBMYCP00000073480; EBMYCG00000075470.
GeneID4550653.
GenomeReviewsGene locus MUL_2184 in contig CP000325_GR.
KEGGmul:MUL_2184.
PATRIC18171483. VBIMycUlc37413_2585.

Organism-specific databases

GenoListMUL_2184.
CMRSearch...

Phylogenomic databases

eggNOGCOG0329.
GeneTreeEBGT00050000016215.
HOGENOMHBG358848.
OMAHGCISVV.
PhylomeDBA0PQH1.
ProtClustDBPRK03170.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0PQH1_MYCUA
AccessionPrimary (citable) accession number: A0PQH1
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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