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A0PQF0 (A0PQF0_MYCUA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183
Gene names
Name:ald EMBL ABL04569.1
Ordered Locus Names:MUL_2154
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183

Pathway

Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183

Sequence similarities

Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
   LigandNAD PIRNR PIRNR000183
   Molecular functionOxidoreductase PIRNR PIRNR000183
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionalanine dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A0PQF0 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 7A3E477F46C24774

FASTA37138,637
        10         20         30         40         50         60 
MRVGIPTETK DNEFRVAITP AGVAALTKRG HEVLIQVGAG EGSAISDSDF KAAGAQLIST 

        70         80         90        100        110        120 
ADQVWADADL LLKVKEPIES EYGRLRRGQT LFTYLHLAAS RPCTDALLKS GTTSIAYETV 

       130        140        150        160        170        180 
QTADGALPLL APMSEVAGRL SAQAGAYHLM RTHGGRGVLM GGVPGVKPAD VVVIGAGTAG 

       190        200        210        220        230        240 
YNAARVANGM GAMVTVLDVN INKLRQIDAE FGGRVRTRYS STLDLEDAAV NADLLIGAVL 

       250        260        270        280        290        300 
VPGAKAPKLI PNSLVARMKK GAVLVDISID QGGCFEDSRP TTHTSPTFTV HDTVFYCVAN 

       310        320        330        340        350        360 
MPGAAPRTST YALTNATMPY VLKLADLGWQ AACLSDSALA KGLSTHEGAL LADHVAADLD 

       370 
LPFTDPASVL G

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References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL04569.1.
RefSeqYP_906040.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PQF0.
SMRA0PQF0. Positions 1-371.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PQF0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000073309; EBMYCP00000071314; EBMYCG00000073304.
GeneID4550816.
GenomeReviewsGene locus MUL_2154 in contig CP000325_GR.
KEGGmul:MUL_2154.
PATRIC18171401. VBIMycUlc37413_2546.

Organism-specific databases

GenoListMUL_2154.
CMRSearch...

Phylogenomic databases

eggNOGCOG0686.
GeneTreeEBGT00050000016024.
HOGENOMHBG289735.
OMAVAHGHEV.
ProtClustDBCLSK792072.

Family and domain databases

InterProIPR008142. Ala_DH/PNT_CS1.
IPR008143. Ala_DH/PNT_CS2.
IPR008141. Ala_DH/Pyr_transHydgase.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
KOK00259.
PANTHERPTHR10160:SF3. PTHR10160:SF3. 1 hit.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFPIRSF000183. Alanine_dh. 1 hit.
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00518. AlaDH. 1 hit.
PROSITEPS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0PQF0_MYCUA
AccessionPrimary (citable) accession number: A0PQF0
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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