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A0PQC4

- IF2_MYCUA

UniProt

A0PQC4 - IF2_MYCUA

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi450 – 4578GTPUniRule annotation
Nucleotide bindingi500 – 5045GTPUniRule annotation
Nucleotide bindingi554 – 5574GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:MUL_2122
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000765: Chromosome

Organism-specific databases

GenoListiMUL_2122.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Translation initiation factor IF-2PRO_1000008285Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362242.MUL_2122.

Structurei

3D structure databases

ProteinModelPortaliA0PQC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini441 – 612172tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni450 – 4578G1By similarity
Regioni475 – 4795G2By similarity
Regioni500 – 5034G3By similarity
Regioni554 – 5574G4By similarity
Regioni590 – 5923G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PQC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES
60 70 80 90 100
FGGGKSAPAK GSDTGAAKGV AKAPQKVSGA SPAAKAPDRS LDAALDKAVG
110 120 130 140 150
NGAPAPVPAP APAPTPAPAP AQPADSGVAP PAATPAAPAA SAAPAPPKAP
160 170 180 190 200
LPGQRPAPTP GKPAAPQAPH PGMAPGARPG PVPKQGVRTP RVGNNPFSSA
210 220 230 240 250
QPVDRPIPRP QAPRPGAPRP GAPRPGGASS GNMPPRPGGA SGGPRPPRTG
260 270 280 290 300
APRPGGGRPG GPGGGRSDGG GGNYRGGGGG VGAAPGGGFR GRPGGGGGGG
310 320 330 340 350
RPGQRGGAAG AFGRPGGAPR RGRKSKRAKR AEYENMQAPV VGGVRLPHGN
360 370 380 390 400
GETIRLARGA SLSDFADKIN ANPAALVQAL FNLGEMVTAT QSVGDETLEL
410 420 430 440 450
LGSEMNYNVQ VVSPEDEDRE LLESFDLTYG EDSGDESELQ TRPPVVTVMG
460 470 480 490 500
HVDHGKTRLL DTIRKANVRE GEAGGITQHI GAYQVSVDHD GTERLITFID
510 520 530 540 550
TPGHEAFTAM RARGAKATDI AILVVAADDG VMPQTVEAIN HAQAADVPIV
560 570 580 590 600
VAVNKIDKEG ADPAKIRGQL TEYGLVAEDF GGDTMFVDIS AKQGTNIEAL
610 620 630 640 650
EEAVLLTADA ALDLRANPDM EAQGVAIEAH LDRGRGPVAT VLVQRGTLRV
660 670 680 690 700
GDSVVAGDAY GRVRRMVDEH GEDVEEALPS RPVQVIGFTS VPGAGDNFLV
710 720 730 740 750
VDEDRIARQI ADRRSARKRN ALAARSRKRI SLEDLDSALK ETSQLNLILK
760 770 780 790 800
GDNAGTVEAL EEALMGIEVD DEVALRVIDR GVGGITETNV NLASASDAII
810 820 830 840 850
IGFNVRAEGK ATELANREGV EIRYYSVIYQ AIDEIEKALR GMLKPIYEEV
860 870 880 890 900
ELGRAEIRAL FRSSKVGLIA GCMISSGVVR RNAKARLLRD NIVVVENLSI
910 920 930 940
RSLRREKDDV TEVREGFECG MTLGYSDLKE GDFIESYELV QKDRS
Length:945
Mass (Da):97,995
Last modified:January 9, 2007 - v1
Checksum:i40A7530CEC0BD849
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000325 Genomic DNA. Translation: ABL04543.1.
RefSeqiWP_011740160.1. NC_008611.1.
YP_906014.1. NC_008611.1.

Genome annotation databases

EnsemblBacteriaiABL04543; ABL04543; MUL_2122.
GeneIDi4550950.
KEGGimul:MUL_2122.
PATRICi18171326. VBIMycUlc37413_2509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000325 Genomic DNA. Translation: ABL04543.1 .
RefSeqi WP_011740160.1. NC_008611.1.
YP_906014.1. NC_008611.1.

3D structure databases

ProteinModelPortali A0PQC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362242.MUL_2122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL04543 ; ABL04543 ; MUL_2122 .
GeneIDi 4550950.
KEGGi mul:MUL_2122.
PATRICi 18171326. VBIMycUlc37413_2509.

Organism-specific databases

GenoListi MUL_2122.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
    Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
    , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
    Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Agy99.

Entry informationi

Entry nameiIF2_MYCUA
AccessioniPrimary (citable) accession number: A0PQC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3