Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0PQC4 (IF2_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:MUL_2122
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length945 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 945945Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000008285

Regions

Nucleotide binding450 – 4578GTP By similarity
Nucleotide binding500 – 5045GTP By similarity
Nucleotide binding554 – 5574GTP By similarity
Region444 – 596153G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
A0PQC4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 40A7530CEC0BD849

FASTA94597,995
        10         20         30         40         50         60 
MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES FGGGKSAPAK 

        70         80         90        100        110        120 
GSDTGAAKGV AKAPQKVSGA SPAAKAPDRS LDAALDKAVG NGAPAPVPAP APAPTPAPAP 

       130        140        150        160        170        180 
AQPADSGVAP PAATPAAPAA SAAPAPPKAP LPGQRPAPTP GKPAAPQAPH PGMAPGARPG 

       190        200        210        220        230        240 
PVPKQGVRTP RVGNNPFSSA QPVDRPIPRP QAPRPGAPRP GAPRPGGASS GNMPPRPGGA 

       250        260        270        280        290        300 
SGGPRPPRTG APRPGGGRPG GPGGGRSDGG GGNYRGGGGG VGAAPGGGFR GRPGGGGGGG 

       310        320        330        340        350        360 
RPGQRGGAAG AFGRPGGAPR RGRKSKRAKR AEYENMQAPV VGGVRLPHGN GETIRLARGA 

       370        380        390        400        410        420 
SLSDFADKIN ANPAALVQAL FNLGEMVTAT QSVGDETLEL LGSEMNYNVQ VVSPEDEDRE 

       430        440        450        460        470        480 
LLESFDLTYG EDSGDESELQ TRPPVVTVMG HVDHGKTRLL DTIRKANVRE GEAGGITQHI 

       490        500        510        520        530        540 
GAYQVSVDHD GTERLITFID TPGHEAFTAM RARGAKATDI AILVVAADDG VMPQTVEAIN 

       550        560        570        580        590        600 
HAQAADVPIV VAVNKIDKEG ADPAKIRGQL TEYGLVAEDF GGDTMFVDIS AKQGTNIEAL 

       610        620        630        640        650        660 
EEAVLLTADA ALDLRANPDM EAQGVAIEAH LDRGRGPVAT VLVQRGTLRV GDSVVAGDAY 

       670        680        690        700        710        720 
GRVRRMVDEH GEDVEEALPS RPVQVIGFTS VPGAGDNFLV VDEDRIARQI ADRRSARKRN 

       730        740        750        760        770        780 
ALAARSRKRI SLEDLDSALK ETSQLNLILK GDNAGTVEAL EEALMGIEVD DEVALRVIDR 

       790        800        810        820        830        840 
GVGGITETNV NLASASDAII IGFNVRAEGK ATELANREGV EIRYYSVIYQ AIDEIEKALR 

       850        860        870        880        890        900 
GMLKPIYEEV ELGRAEIRAL FRSSKVGLIA GCMISSGVVR RNAKARLLRD NIVVVENLSI 

       910        920        930        940 
RSLRREKDDV TEVREGFECG MTLGYSDLKE GDFIESYELV QKDRS 

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000325 Genomic DNA. Translation: ABL04543.1.
RefSeqYP_906014.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PQC4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362242.MUL_2122.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL04543; ABL04543; MUL_2122.
GeneID4550950.
KEGGmul:MUL_2122.
PATRIC18171326. VBIMycUlc37413_2509.

Organism-specific databases

GenoListMUL_2122.
CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMANPDMDAQ.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_MYCUA
AccessionPrimary (citable) accession number: A0PQC4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries