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A0PQC4

- IF2_MYCUA

UniProt

A0PQC4 - IF2_MYCUA

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi450 – 4578GTPUniRule annotation
    Nucleotide bindingi500 – 5045GTPUniRule annotation
    Nucleotide bindingi554 – 5574GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:MUL_2122
    OrganismiMycobacterium ulcerans (strain Agy99)
    Taxonomic identifieri362242 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000765: Chromosome

    Organism-specific databases

    GenoListiMUL_2122.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 945945Translation initiation factor IF-2PRO_1000008285Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362242.MUL_2122.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PQC4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini441 – 612172tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni450 – 4578G1By similarity
    Regioni475 – 4795G2By similarity
    Regioni500 – 5034G3By similarity
    Regioni554 – 5574G4By similarity
    Regioni590 – 5923G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiNPDMDAQ.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0PQC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES    50
    FGGGKSAPAK GSDTGAAKGV AKAPQKVSGA SPAAKAPDRS LDAALDKAVG 100
    NGAPAPVPAP APAPTPAPAP AQPADSGVAP PAATPAAPAA SAAPAPPKAP 150
    LPGQRPAPTP GKPAAPQAPH PGMAPGARPG PVPKQGVRTP RVGNNPFSSA 200
    QPVDRPIPRP QAPRPGAPRP GAPRPGGASS GNMPPRPGGA SGGPRPPRTG 250
    APRPGGGRPG GPGGGRSDGG GGNYRGGGGG VGAAPGGGFR GRPGGGGGGG 300
    RPGQRGGAAG AFGRPGGAPR RGRKSKRAKR AEYENMQAPV VGGVRLPHGN 350
    GETIRLARGA SLSDFADKIN ANPAALVQAL FNLGEMVTAT QSVGDETLEL 400
    LGSEMNYNVQ VVSPEDEDRE LLESFDLTYG EDSGDESELQ TRPPVVTVMG 450
    HVDHGKTRLL DTIRKANVRE GEAGGITQHI GAYQVSVDHD GTERLITFID 500
    TPGHEAFTAM RARGAKATDI AILVVAADDG VMPQTVEAIN HAQAADVPIV 550
    VAVNKIDKEG ADPAKIRGQL TEYGLVAEDF GGDTMFVDIS AKQGTNIEAL 600
    EEAVLLTADA ALDLRANPDM EAQGVAIEAH LDRGRGPVAT VLVQRGTLRV 650
    GDSVVAGDAY GRVRRMVDEH GEDVEEALPS RPVQVIGFTS VPGAGDNFLV 700
    VDEDRIARQI ADRRSARKRN ALAARSRKRI SLEDLDSALK ETSQLNLILK 750
    GDNAGTVEAL EEALMGIEVD DEVALRVIDR GVGGITETNV NLASASDAII 800
    IGFNVRAEGK ATELANREGV EIRYYSVIYQ AIDEIEKALR GMLKPIYEEV 850
    ELGRAEIRAL FRSSKVGLIA GCMISSGVVR RNAKARLLRD NIVVVENLSI 900
    RSLRREKDDV TEVREGFECG MTLGYSDLKE GDFIESYELV QKDRS 945
    Length:945
    Mass (Da):97,995
    Last modified:January 9, 2007 - v1
    Checksum:i40A7530CEC0BD849
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL04543.1.
    RefSeqiYP_906014.1. NC_008611.1.

    Genome annotation databases

    EnsemblBacteriaiABL04543; ABL04543; MUL_2122.
    GeneIDi4550950.
    KEGGimul:MUL_2122.
    PATRICi18171326. VBIMycUlc37413_2509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL04543.1 .
    RefSeqi YP_906014.1. NC_008611.1.

    3D structure databases

    ProteinModelPortali A0PQC4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362242.MUL_2122.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL04543 ; ABL04543 ; MUL_2122 .
    GeneIDi 4550950.
    KEGGi mul:MUL_2122.
    PATRICi 18171326. VBIMycUlc37413_2509.

    Organism-specific databases

    GenoListi MUL_2122.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi NPDMDAQ.
    OrthoDBi EOG67HJSV.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
      Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
      , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
      Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Agy99.

    Entry informationi

    Entry nameiIF2_MYCUA
    AccessioniPrimary (citable) accession number: A0PQC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3