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A0PQC4

- IF2_MYCUA

UniProt

A0PQC4 - IF2_MYCUA

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Protein
Translation initiation factor IF-2
Gene
infB, MUL_2122
Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi450 – 4578GTP By similarity
Nucleotide bindingi500 – 5045GTP By similarity
Nucleotide bindingi554 – 5574GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:MUL_2122
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000765: Chromosome

Organism-specific databases

GenoListiMUL_2122.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Translation initiation factor IF-2UniRule annotation
PRO_1000008285Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362242.MUL_2122.

Structurei

3D structure databases

ProteinModelPortaliA0PQC4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini441 – 612172tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni450 – 4578G1 By similarity
Regioni475 – 4795G2 By similarity
Regioni500 – 5034G3 By similarity
Regioni554 – 5574G4 By similarity
Regioni590 – 5923G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiNPDMDAQ.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PQC4-1 [UniParc]FASTAAdd to Basket

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MAGKARVHEL AKELGVTSKE VLARLSEQGE FVKSASSTVE APVARRLRES    50
FGGGKSAPAK GSDTGAAKGV AKAPQKVSGA SPAAKAPDRS LDAALDKAVG 100
NGAPAPVPAP APAPTPAPAP AQPADSGVAP PAATPAAPAA SAAPAPPKAP 150
LPGQRPAPTP GKPAAPQAPH PGMAPGARPG PVPKQGVRTP RVGNNPFSSA 200
QPVDRPIPRP QAPRPGAPRP GAPRPGGASS GNMPPRPGGA SGGPRPPRTG 250
APRPGGGRPG GPGGGRSDGG GGNYRGGGGG VGAAPGGGFR GRPGGGGGGG 300
RPGQRGGAAG AFGRPGGAPR RGRKSKRAKR AEYENMQAPV VGGVRLPHGN 350
GETIRLARGA SLSDFADKIN ANPAALVQAL FNLGEMVTAT QSVGDETLEL 400
LGSEMNYNVQ VVSPEDEDRE LLESFDLTYG EDSGDESELQ TRPPVVTVMG 450
HVDHGKTRLL DTIRKANVRE GEAGGITQHI GAYQVSVDHD GTERLITFID 500
TPGHEAFTAM RARGAKATDI AILVVAADDG VMPQTVEAIN HAQAADVPIV 550
VAVNKIDKEG ADPAKIRGQL TEYGLVAEDF GGDTMFVDIS AKQGTNIEAL 600
EEAVLLTADA ALDLRANPDM EAQGVAIEAH LDRGRGPVAT VLVQRGTLRV 650
GDSVVAGDAY GRVRRMVDEH GEDVEEALPS RPVQVIGFTS VPGAGDNFLV 700
VDEDRIARQI ADRRSARKRN ALAARSRKRI SLEDLDSALK ETSQLNLILK 750
GDNAGTVEAL EEALMGIEVD DEVALRVIDR GVGGITETNV NLASASDAII 800
IGFNVRAEGK ATELANREGV EIRYYSVIYQ AIDEIEKALR GMLKPIYEEV 850
ELGRAEIRAL FRSSKVGLIA GCMISSGVVR RNAKARLLRD NIVVVENLSI 900
RSLRREKDDV TEVREGFECG MTLGYSDLKE GDFIESYELV QKDRS 945
Length:945
Mass (Da):97,995
Last modified:January 9, 2007 - v1
Checksum:i40A7530CEC0BD849
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000325 Genomic DNA. Translation: ABL04543.1.
RefSeqiYP_906014.1. NC_008611.1.

Genome annotation databases

EnsemblBacteriaiABL04543; ABL04543; MUL_2122.
GeneIDi4550950.
KEGGimul:MUL_2122.
PATRICi18171326. VBIMycUlc37413_2509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000325 Genomic DNA. Translation: ABL04543.1 .
RefSeqi YP_906014.1. NC_008611.1.

3D structure databases

ProteinModelPortali A0PQC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362242.MUL_2122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL04543 ; ABL04543 ; MUL_2122 .
GeneIDi 4550950.
KEGGi mul:MUL_2122.
PATRICi 18171326. VBIMycUlc37413_2509.

Organism-specific databases

GenoListi MUL_2122.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi NPDMDAQ.
OrthoDBi EOG67HJSV.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
    Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
    , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
    Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Agy99.

Entry informationi

Entry nameiIF2_MYCUA
AccessioniPrimary (citable) accession number: A0PQC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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