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A0PPX5 (A0PPX5_MYCUA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase HAMAP-Rule MF_00339

Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339
Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339
Gene names
Name:pfkA HAMAP-Rule MF_00339 EMBL ABL04394.1
Ordered Locus Names:MUL_1940 EMBL ABL04394.1
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP] EMBL ABL04394.1
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding20 – 245ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding155 – 1595ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding172 – 18817ATP By similarity HAMAP-Rule MF_00339

Sites

Active site1281Proton acceptor By similarity HAMAP-Rule MF_00339
Binding site1631Substrate By similarity HAMAP-Rule MF_00339
Binding site2671Substrate By similarity HAMAP-Rule MF_00339
Binding site2731Substrate By similarity HAMAP-Rule MF_00339
Binding site2761Substrate By similarity HAMAP-Rule MF_00339

Sequences

Sequence LengthMass (Da)Tools
A0PPX5 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 034D443205F5FD41

FASTA34337,243
        10         20         30         40         50         60 
MRIGVLTGGG DCPGLNAVIR AVVRTCDARY GSSVVGFQDG WRGLLENRRL QLRNDDRNDR 

        70         80         90        100        110        120 
LLAKGGTMLG TARVHPDKLR AGLPQIKQTL DDNGIDVLIP IGGEGTLTAA HWLSEENVPV 

       130        140        150        160        170        180 
VGVPKTIDND IDCTDVTFGH DTALMVATEA IDRLHSTAES HQRVMLVEVM GRHAGWIALN 

       190        200        210        220        230        240 
SGLASGAHMT LIPEQPFDIE EVCRLVKQRF QRGDSHFICV VAEGAKPVSG SMQLREGGLD 

       250        260        270        280        290        300 
EFGHERFTGV AAQLGWEVEK RINKDVRVTV LGHVQRGGQP TAYDRVLATR FGVNAADAAH 

       310        320        330        340 
AGEYGQMVSL RGQDIGRVPL ADAVRQLKLV PQSRYDDAAE FFG 

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D., Davies J.K., Jenkin G.A., Small P.L., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99 EMBL ABL04394.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000325 Genomic DNA. Translation: ABL04394.1.
RefSeqYP_905865.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PPX5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362242.MUL_1940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL04394; ABL04394; MUL_1940.
GeneID4551281.
KEGGmul:MUL_1940.
PATRIC18170921. VBIMycUlc37413_2311.

Organism-specific databases

GenoListMUL_1940.
CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000248869.
KOK00850.
OMAWVGLMED.
OrthoDBEOG644ZRM.
ProtClustDBPRK03202.

Enzyme and pathway databases

UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012829. PFK.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
TIGRFAMsTIGR02483. PFK_mixed. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0PPX5_MYCUA
AccessionPrimary (citable) accession number: A0PPX5
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)