A0PPP5 (TAL_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transaldolase
EC=2.2.1.2

Gene names

Name:	tal
Ordered Locus Names:	MUL_1843

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway By similarity. HAMAP MF_00493
Catalytic activity	Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. HAMAP MF_00493
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. HAMAP MF_00493
Subcellular location	Cytoplasm By similarity HAMAP MF_00493.
Sequence similarities	Belongs to the transaldolase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Pentose shunt
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Transaldolase HAMAP MF_00493		PRO_1000026528
Sites
	Active site	143	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0PPP5 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: A4E78EF2C0954AF4	FASTA	373	40,162
	10 20 30 40 50 60 MASQKPNLAA LSAAGVSVWL DDLSRDRLRS GNLQELIDTK SVVGVTTNPS IFQKALSEGH 70 80 90 100 110 120 DYDAQVAELA ERGADVDATI RTVTTDDVRN ACDVLAPRWE ASGGVDGRVS IEVDPRLAHE 130 140 150 160 170 180 TDKTIQQAVE LWKIVDRPNL LIKIPATKAG LPAIAAVLAE GISVNVTLIF SVDRHRGVMD 190 200 210 220 230 240 AYLTGMEKAA QAGHDLSKIH SVASFFVSRV DTEIDNRLEQ IGSAEALALR GQAGVANARL 250 260 270 280 290 300 AYAAYQEVFE GDARYQALKE RGARVQRPLW ASTGVKNPDY SDTLYVTELV APHTVNTMPE 310 320 330 340 350 360 KTLDAVADHG VVKGDSITGT SGDAQQVFDK LEAIGIDLSD VFDVLESEGV EKFEASWKEL 370 LDATQAQLDA LAK

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL04314.1.
RefSeq	YP_905785.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PPP5.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PPP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000073793; EBMYCP00000071798; EBMYCG00000073788.
GeneID	4551663.
GenomeReviews	Gene locus MUL_1843 in contig CP000325_GR.
KEGG	mul:MUL_1843.
PATRIC	18170702. VBIMycUlc37413_2202.
Organism-specific databases
GenoList	MUL_1843.
CMR	Search...
Phylogenomic databases
eggNOG	COG0176.
GeneTree	EBGT00050000017406.
HOGENOM	HBG321149.
OMA	MPEKTLD.
ProtClustDB	PRK03343.
Family and domain databases
HAMAP	MF_00493. Transaldolase_2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001585. Transaldolase. IPR004732. Transaldolase_2. IPR018225. Transaldolase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00616.
PANTHER	PTHR10683. Transaldolase. 1 hit.
Pfam	PF00923. Transaldolase. 1 hit. [Graphical view]
PIRSF	PIRSF036915. Trnald_Bac_Plnt. 1 hit.
TIGRFAMs	TIGR00876. Tal_mycobact. 1 hit.
PROSITE	PS01054. TRANSALDOLASE_1. 1 hit. PS00958. TRANSALDOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TAL_MYCUA

Accession

Primary (citable) accession number: A0PPP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program