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A0PPN8

- CAPP_MYCUA

UniProt

A0PPN8 - CAPP_MYCUA

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei161 – 1611UniRule annotation
Active sitei593 – 5931UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:MUL_1836
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000765: Chromosome

Organism-specific databases

GenoListiMUL_1836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 935935Phosphoenolpyruvate carboxylasePRO_1000025567Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362242.MUL_1836.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiELSTISC.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PPN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEVSDTALE PIGDVHRTRI GREATEPMRA DIRLLGAILG DTVREQNGDE
60 70 80 90 100
VFELVERARV EAFRVRHSEI DRAEMARMFE GIDIHHAIPI IRAFSHFALL
110 120 130 140 150
ANVAEDIHRE RRRSIHVAAG EPPRDSSLTA TYMKLYAAQL DSATIAEALK
160 170 180 190 200
GALVSPVITA HPTETRRRTI FETQHRITQL MRLHAEGHTE TDDGRGIEVE
210 220 230 240 250
LRRQVLRLWQ TALIRLFRLQ ISDEIEVGLR YYPAALFEVI SQVNAEVRDA
260 270 280 290 300
LRARWPDADL LSEPILRPGS WIGGDRDGNP NVTAEVVRLA TGSAAFTALA
310 320 330 340 350
HYLAELTALA QELSMSARLI TVTPELATLA DACPAGARPD EPYRRALQVV
360 370 380 390 400
RGRLSATAAE ILDQQPQHTL ELGLPPYATA AELRADLDTI DASLHNHGAG
410 420 430 440 450
LLADDRLARL REAVRVFGFH LSGLDMRQNS DVHEQVVGEL LAWAGVHPDY
460 470 480 490 500
TSLAEAERVE LLAAELSTRR PLIRDGAQLS DLARSELGVL AAAAHAVWTF
510 520 530 540 550
GPAAVPNYII SMCWSVSDML EAAVLLKEVG LLDASESEPY CPVGISPLFE
560 570 580 590 600
TIEDLHNGAA ILQAMLDLPL YRALVTARGG CQEVMLGYSD SNKDGGYLAA
610 620 630 640 650
NWAVYRAELA LVETARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA
660 670 680 690 700
VSGSLRLTEQ GEVIAAKYAE PQMARRNLES LLAATLESTL LAVEGLGDTA
710 720 730 740 750
APAYAVLDEV AALAQRAYAE LVHETPGFVE YFKASTPVSE FGALNIGSRP
760 770 780 790 800
TSRKPTASIA DLRAIPWVLA WSQSRVMLPG WYGTGSAFEQ WLAAGPESEA
810 820 830 840 850
DRLQVLHDLY QRWPFFRSVL SNMAQVMAKS DLELAARYSE LVADETLRRR
860 870 880 890 900
VFDKIADEHH RTIAMYKRIT GQDDLLADNP ALARSVFNRF PYLEPLNHLQ
910 920 930
VELLRRYRSG EDDESVQRGI LLTMNGLASA LRNSG
Length:935
Mass (Da):102,784
Last modified:January 9, 2007 - v1
Checksum:i4A790C15C4CFB92D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL04307.1.
RefSeqiWP_011739927.1. NC_008611.1.
YP_905778.1. NC_008611.1.

Genome annotation databases

EnsemblBacteriaiABL04307; ABL04307; MUL_1836.
GeneIDi4551687.
KEGGimul:MUL_1836.
PATRICi18170688. VBIMycUlc37413_2195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL04307.1 .
RefSeqi WP_011739927.1. NC_008611.1.
YP_905778.1. NC_008611.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362242.MUL_1836.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABL04307 ; ABL04307 ; MUL_1836 .
GeneIDi 4551687.
KEGGi mul:MUL_1836.
PATRICi 18170688. VBIMycUlc37413_2195.

Organism-specific databases

GenoListi MUL_1836.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi ELSTISC.
OrthoDBi EOG6TJ7T8.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
    Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
    , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
    Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Agy99.

Entry informationi

Entry nameiCAPP_MYCUA
AccessioniPrimary (citable) accession number: A0PPN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3