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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei161UniRule annotation1
Active sitei593UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbon dioxide fixation
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:MUL_1836
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000765 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000255671 – 935Phosphoenolpyruvate carboxylaseAdd BLAST935

Proteomic databases

PRIDEiA0PPN8

Structurei

3D structure databases

SMRiA0PPN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000238647
KOiK01595
OMAiPWVFGWT
OrthoDBiPOG091H040O

Family and domain databases

HAMAPiMF_00595 PEPcase_type1, 1 hit
InterProiView protein in InterPro
IPR021135 PEP_COase
IPR022805 PEP_COase_bac/pln-type
IPR018129 PEP_COase_Lys_AS
IPR033129 PEPCASE_His_AS
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PANTHERiPTHR30523 PTHR30523, 1 hit
PfamiView protein in Pfam
PF00311 PEPcase, 1 hit
PRINTSiPR00150 PEPCARBXLASE
SUPFAMiSSF51621 SSF51621, 1 hit
PROSITEiView protein in PROSITE
PS00781 PEPCASE_1, 1 hit
PS00393 PEPCASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0PPN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEVSDTALE PIGDVHRTRI GREATEPMRA DIRLLGAILG DTVREQNGDE
60 70 80 90 100
VFELVERARV EAFRVRHSEI DRAEMARMFE GIDIHHAIPI IRAFSHFALL
110 120 130 140 150
ANVAEDIHRE RRRSIHVAAG EPPRDSSLTA TYMKLYAAQL DSATIAEALK
160 170 180 190 200
GALVSPVITA HPTETRRRTI FETQHRITQL MRLHAEGHTE TDDGRGIEVE
210 220 230 240 250
LRRQVLRLWQ TALIRLFRLQ ISDEIEVGLR YYPAALFEVI SQVNAEVRDA
260 270 280 290 300
LRARWPDADL LSEPILRPGS WIGGDRDGNP NVTAEVVRLA TGSAAFTALA
310 320 330 340 350
HYLAELTALA QELSMSARLI TVTPELATLA DACPAGARPD EPYRRALQVV
360 370 380 390 400
RGRLSATAAE ILDQQPQHTL ELGLPPYATA AELRADLDTI DASLHNHGAG
410 420 430 440 450
LLADDRLARL REAVRVFGFH LSGLDMRQNS DVHEQVVGEL LAWAGVHPDY
460 470 480 490 500
TSLAEAERVE LLAAELSTRR PLIRDGAQLS DLARSELGVL AAAAHAVWTF
510 520 530 540 550
GPAAVPNYII SMCWSVSDML EAAVLLKEVG LLDASESEPY CPVGISPLFE
560 570 580 590 600
TIEDLHNGAA ILQAMLDLPL YRALVTARGG CQEVMLGYSD SNKDGGYLAA
610 620 630 640 650
NWAVYRAELA LVETARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA
660 670 680 690 700
VSGSLRLTEQ GEVIAAKYAE PQMARRNLES LLAATLESTL LAVEGLGDTA
710 720 730 740 750
APAYAVLDEV AALAQRAYAE LVHETPGFVE YFKASTPVSE FGALNIGSRP
760 770 780 790 800
TSRKPTASIA DLRAIPWVLA WSQSRVMLPG WYGTGSAFEQ WLAAGPESEA
810 820 830 840 850
DRLQVLHDLY QRWPFFRSVL SNMAQVMAKS DLELAARYSE LVADETLRRR
860 870 880 890 900
VFDKIADEHH RTIAMYKRIT GQDDLLADNP ALARSVFNRF PYLEPLNHLQ
910 920 930
VELLRRYRSG EDDESVQRGI LLTMNGLASA LRNSG
Length:935
Mass (Da):102,784
Last modified:January 9, 2007 - v1
Checksum:i4A790C15C4CFB92D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA Translation: ABL04307.1
RefSeqiWP_011739927.1, NC_008611.1

Genome annotation databases

EnsemblBacteriaiABL04307; ABL04307; MUL_1836
KEGGimul:MUL_1836

Similar proteinsi

Entry informationi

Entry nameiCAPP_MYCUA
AccessioniPrimary (citable) accession number: A0PPN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health