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A0PPN8 (CAPP_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase

Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppc
Ordered Locus Names:MUL_1836
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length935 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00595

Sequence similarities

Belongs to the PEPCase type 1 family.

Ontologies

Keywords
   Biological processCarbon dioxide fixation
   LigandMagnesium
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbon fixation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

oxaloacetate metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoenolpyruvate carboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 935935Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595
PRO_1000025567

Sites

Active site1611 By similarity
Active site5931 By similarity

Sequences

Sequence LengthMass (Da)Tools
A0PPN8 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 4A790C15C4CFB92D

FASTA935102,784
        10         20         30         40         50         60 
MVEVSDTALE PIGDVHRTRI GREATEPMRA DIRLLGAILG DTVREQNGDE VFELVERARV 

        70         80         90        100        110        120 
EAFRVRHSEI DRAEMARMFE GIDIHHAIPI IRAFSHFALL ANVAEDIHRE RRRSIHVAAG 

       130        140        150        160        170        180 
EPPRDSSLTA TYMKLYAAQL DSATIAEALK GALVSPVITA HPTETRRRTI FETQHRITQL 

       190        200        210        220        230        240 
MRLHAEGHTE TDDGRGIEVE LRRQVLRLWQ TALIRLFRLQ ISDEIEVGLR YYPAALFEVI 

       250        260        270        280        290        300 
SQVNAEVRDA LRARWPDADL LSEPILRPGS WIGGDRDGNP NVTAEVVRLA TGSAAFTALA 

       310        320        330        340        350        360 
HYLAELTALA QELSMSARLI TVTPELATLA DACPAGARPD EPYRRALQVV RGRLSATAAE 

       370        380        390        400        410        420 
ILDQQPQHTL ELGLPPYATA AELRADLDTI DASLHNHGAG LLADDRLARL REAVRVFGFH 

       430        440        450        460        470        480 
LSGLDMRQNS DVHEQVVGEL LAWAGVHPDY TSLAEAERVE LLAAELSTRR PLIRDGAQLS 

       490        500        510        520        530        540 
DLARSELGVL AAAAHAVWTF GPAAVPNYII SMCWSVSDML EAAVLLKEVG LLDASESEPY 

       550        560        570        580        590        600 
CPVGISPLFE TIEDLHNGAA ILQAMLDLPL YRALVTARGG CQEVMLGYSD SNKDGGYLAA 

       610        620        630        640        650        660 
NWAVYRAELA LVETARKTGI RLRLFHGRGG TVGRGGGPSY QAILAQPPGA VSGSLRLTEQ 

       670        680        690        700        710        720 
GEVIAAKYAE PQMARRNLES LLAATLESTL LAVEGLGDTA APAYAVLDEV AALAQRAYAE 

       730        740        750        760        770        780 
LVHETPGFVE YFKASTPVSE FGALNIGSRP TSRKPTASIA DLRAIPWVLA WSQSRVMLPG 

       790        800        810        820        830        840 
WYGTGSAFEQ WLAAGPESEA DRLQVLHDLY QRWPFFRSVL SNMAQVMAKS DLELAARYSE 

       850        860        870        880        890        900 
LVADETLRRR VFDKIADEHH RTIAMYKRIT GQDDLLADNP ALARSVFNRF PYLEPLNHLQ 

       910        920        930 
VELLRRYRSG EDDESVQRGI LLTMNGLASA LRNSG 

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000325 Genomic DNA. Translation: ABL04307.1.
RefSeqYP_905778.1. NC_008611.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362242.MUL_1836.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABL04307; ABL04307; MUL_1836.
GeneID4551687.
KEGGmul:MUL_1836.
PATRIC18170688. VBIMycUlc37413_2195.

Organism-specific databases

GenoListMUL_1836.
CMRSearch...

Phylogenomic databases

eggNOGCOG2352.
HOGENOMHOG000238647.
KOK01595.
OMAELSTISC.
OrthoDBEOG6TJ7T8.

Family and domain databases

HAMAPMF_00595. PEPcase_type1.
InterProIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSPR00150. PEPCARBXLASE.
SUPFAMSSF51621. SSF51621. 1 hit.
PROSITEPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPP_MYCUA
AccessionPrimary (citable) accession number: A0PPN8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families