A0PPI8 (PYRB_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	MUL_1780

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301593

Sequences

	Sequence		Length	Mass (Da)
	A0PPI8 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 193E398D502F6DD2	FASTA	320	33,838
	10 20 30 40 50 60 MTPRHLLAAG DLSRDDAIAI LDDADRFAQA LVGREVKKLP TLRGRTVVTM FYENSTRTRV 70 80 90 100 110 120 SFEVAGKWMS ADLINVSASG SSVSKGESLR DTALTLRAAG ADALIIRHPA SGAARLFADW 130 140 150 160 170 180 TAGQSDGGPS VINAGDGTHE HPTQALLDAL TIRQRLGGIE GRRVVIVGDI LHSRVARSNV 190 200 210 220 230 240 TLLHTLGAEV VLVAPPTLLP VGVADWPVTV SHDLDAELPA ADAVLMLRVQ AERMNGGFFP 250 260 270 280 290 300 SVREYSTLYG LSDRRQAMLG GHAVVLHPGP MLRGMEIASS VADSSQSAVL QQVSNGVHIR 310 320 MAVLFHVLVG LESAGEEGAA

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL04257.1.
RefSeq	YP_905728.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PPI8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PPI8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000075029; EBMYCP00000073034; EBMYCG00000075024.
GeneID	4551743.
GenomeReviews	Gene locus MUL_1780 in contig CP000325_GR.
KEGG	mul:MUL_1780.
PATRIC	18170561. VBIMycUlc37413_2132.
Organism-specific databases
GenoList	MUL_1780.
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000016463.
HOGENOM	HBG579429.
OMA	VGIPIIN.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_MYCUA

Accession

Primary (citable) accession number: A0PPI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program