A0PPA4 (A0PPA4_MYCUA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361
Short name=Poly(P)/ATP NAD kinase HAMAP MF_00361
EC=2.7.1.23 HAMAP MF_00361

Gene names

Name:	ppnK HAMAP MF_00361 EMBL ABL04173.1
Ordered Locus Names:	MUL_1684

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361 SAAS SAAS002504
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361 SAAS SAAS002504
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361 SAAS SAAS002504
Subcellular location	Cytoplasm By similarity HAMAP MF_00361 SAAS SAAS002504.
Sequence similarities	Belongs to the NAD kinase family. HAMAP MF_00361

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00361 SAAS SAAS002504
Ligand	ATP-binding HAMAP MF_00361 SAAS SAAS002504 NAD HAMAP MF_00361 SAAS SAAS002504 NADP HAMAP MF_00361 SAAS SAAS002504 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00361 SAAS SAAS002504 EMBL ABL04173.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0PPA4 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 4E1FCBCD2F208801	FASTA	307	32,972
	10 20 30 40 50 60 MTATRTVLLV VHTGRDEATE TARRVEKVLG DNGIALRVLS AEAVDRGSLH LAPDDMRALG 70 80 90 100 110 120 IDIEVVDADP RAADGCELVL VLGGDGTFLR AAELARNAQI PVLGVNLGRI GFLAEAEAEA 130 140 150 160 170 180 IDRVLDHVVA RDYRVEERLT LDVVVRKAGC DLERGWALNE VSLEKGPRLG VLGVVVEIDG 190 200 210 220 230 240 RSVSAFGCDG VLVSTPTGST AYAFSAGGPV LWPDLEAILV VPNNAHALFG RPMVTSPEAT 250 260 270 280 290 300 IAVEIEPDGH DAMVFCDGRR EMLMPAGSRL EVTRCDTPVK WARLDSAPFT DRLVHKFRLP VTGWRGK

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL04173.1.
RefSeq	YP_905644.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PPA4.
SMR	A0PPA4. Positions 2-305.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PPA4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000074719; EBMYCP00000072724; EBMYCG00000074714.
GeneID	4551918.
GenomeReviews	Gene locus MUL_1684 in contig CP000325_GR.
KEGG	mul:MUL_1684.
PATRIC	18170346. VBIMycUlc37413_2025.
Organism-specific databases
GenoList	MUL_1684.
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000016530.
HOGENOM	HBG713904.
OMA	GPVVWPE.
PhylomeDB	A0PPA4.
ProtClustDB	PRK03372.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0PPA4_MYCUA

Accession

Primary (citable) accession number: A0PPA4

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)