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A0PP80 (ARLY_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:MUL_1651
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Argininosuccinate lyase HAMAP MF_00006
PRO_1000000511

Sequences

Sequence LengthMass (Da)Tools
A0PP80 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 2719833C249791AC

FASTA47049,895
        10         20         30         40         50         60 
MSTNQGSLWG GRFAGGPSDA LAALSKSTHF DWALAPYDVT ASRAHAVVLF RAGLLTEEQR 

        70         80         90        100        110        120 
DGLLAGLDSL ASDVADGSFG PLVSDEDVHA ALERGLIDRV GPDLGGRLRA GRSRNDQVAT 

       130        140        150        160        170        180 
LFRMWLRDAV RRVATGVLEV VAALGDQAAA HPTAIMPGKT HLQSAQPILL AHHLLAHAHP 

       190        200        210        220        230        240 
LLRDVERIVD FDKRAAVSPY GSGALAGSSL GLDPDAIAAD LGFTTAADNS VDATASRDFA 

       250        260        270        280        290        300 
AEAAFVFAMI AVDLSRLAED IIIWSSTEFG YVTLHDSWST GSSIMPQKKN PDIAELARGK 

       310        320        330        340        350        360 
SGRLIGNLTG LLATLKSQPL AYNRDLQEDK EPVFDSVVQL ELLLPAMAGL VGSLTFDVER 

       370        380        390        400        410        420 
MAALAPAGYT LATDVAEWLV RQGVPFRSAH EAAGAAVRTA EERSVGLEEL TDDELAAISP 

       430        440        450        460        470 
ELTPQVRDVL TIEGSVSARD SRGGTAPKRV AEQLQIVREI TARLGHELMR

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL04149.1.
RefSeqYP_905620.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PP80.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PP80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000074550; EBMYCP00000072555; EBMYCG00000074545.
GeneID4552064.
GenomeReviewsGene locus MUL_1651 in contig CP000325_GR.
KEGGmul:MUL_1651.
PATRIC18170254. VBIMycUlc37413_1980.

Organism-specific databases

GenoListMUL_1651.
CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00050000016253.
HOGENOMHBG539632.
OMAMPGRTHL.
ProtClustDBPRK00855.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_MYCUA
AccessionPrimary (citable) accession number: A0PP80
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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