Skip Header

Contribute Send feedback
Read comments (?) or add your own

A0PP66 (A0PP66_MYCUA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phenylalanine--tRNA ligase alpha chain HAMAP MF_00281
EC=6.1.1.20 HAMAP MF_00281
Alternative name(s):
Phenylalanyl-tRNA synthetase alpha chain HAMAP MF_00281
Gene names
Name:pheS HAMAP MF_00281 EMBL ABL04135.1
Ordered Locus Names:MUL_1635
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). HAMAP MF_00281

Cofactor

Binds 2 magnesium ions per tetramer By similarity. HAMAP MF_00281

Subunit structure

Tetramer of two alpha and two beta chains By similarity. HAMAP MF_00281

Subcellular location

Cytoplasm By similarity HAMAP MF_00281.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily. HAMAP MF_00281

Sequences

Sequence LengthMass (Da)Tools
A0PP66 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: F06F4E51245B0206

FASTA34738,200
        10         20         30         40         50         60 
MGDQPVDLSP QGLANVVKLA HQAFASADNL EALARAKTEH LGDRSPLALA RQSLGTLPKE 

        70         80         90        100        110        120 
QRADAGKAVN LARGDAQCSY DERLAVLRAE RDAAVLVAER IDVTLPSTRQ PTGARHPITI 

       130        140        150        160        170        180 
LAEHIADTFI AMGWELAEGP EVETEQFNFD ALNFPPDHPA RSEQDTFYIA PEDSRQLLRT 

       190        200        210        220        230        240 
HTSPVQVRTL LERELPVYII SIGRTFRTDE LDATHTPVFH QVEGLAVDRG LTMAHLRGTL 

       250        260        270        280        290        300 
DAFARSEFGP LARTRIRPHF FPFTEPSAEV DVWFANKKGG ADWVEWGGCG MVHPNVLRAA 

       310        320        330        340 
GIDPEVYSGF AFGMGLERSL QFRNGIPDMR DMVEGDVRFS LPFGVGA

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL04135.1.
RefSeqYP_905606.1. NC_008611.1.

3D structure databases

ProteinModelPortalA0PP66.
ModBaseSearch...

Protein-protein interaction databases

STRINGA0PP66.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000074363; EBMYCP00000072368; EBMYCG00000074358.
GeneID4552084.
GenomeReviewsGene locus MUL_1635 in contig CP000325_GR.
KEGGmul:MUL_1635.
PATRIC18170214. VBIMycUlc37413_1960.

Organism-specific databases

GenoListMUL_1635.
CMRSearch...

Phylogenomic databases

eggNOGCOG0016.
GeneTreeEBGT00050000016426.
HOGENOMHBG284353.
OMAFRASYFP.
PhylomeDBA0PP66.
ProtClustDBPRK00488.

Family and domain databases

HAMAPMF_00281. Phe_tRNA_synth_alpha1.
[Tree]
InterProIPR006195. aa-tRNA-synth_II.
IPR004529. Phe-tRNA-synth_IIc_asu.
IPR004188. Phe-tRNA_synth_II_N.
IPR022911. Phe_tRNA_synth_alpha1_bac.
IPR002319. Phenylalanyl-tRNA_Synthase.
IPR010978. tRNA-bd_arm.
[Graphical view]
KOK01889.
PfamPF02912. Phe_tRNA-synt_N. 1 hit.
PF01409. tRNA-synt_2d. 1 hit.
[Graphical view]
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
TIGRFAMsTIGR00468. PheS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA0PP66_MYCUA
AccessionPrimary (citable) accession number: A0PP66
Entry history
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info