A0PP28 (TRPC_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	MUL_1591

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018506

Sequences

	Sequence		Length	Mass (Da)
	A0PP28 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 53A6EB4A3E98F8F6	FASTA	272	28,105
	10 20 30 40 50 60 MSPATVLDSI LEGVRADVAA REALVGMTEI KAAAAAAPPP LDVMAALRQP GIGVIAEVKR 70 80 90 100 110 120 ASPSAGSLAP ITDPAKLARA YEDGGARIIS VLTEGRRFQG SLDDLDAVRA AVSIPLLRKD 130 140 150 160 170 180 FVVQPYQIHE ARAHGADMLL LIVAALDQSA LVSMLDRTES LGMTALVEVH TEQEADRALK 190 200 210 220 230 240 AGAKVIGVNA RDLTTLEVDR DCFARIASGL PSNVIRIAES GVRGTNDLLA YAGAGADAVL 250 260 270 VGEGLVKSGD PRAAVADLVT AGTHPSCPKP AR

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL04097.1.
RefSeq	YP_905568.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PP28.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PP28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000073342; EBMYCP00000071347; EBMYCG00000073337.
GeneID	4552114.
GenomeReviews	Gene locus MUL_1591 in contig CP000325_GR.
KEGG	mul:MUL_1591.
PATRIC	18170109. VBIMycUlc37413_1909.
Organism-specific databases
GenoList	MUL_1591.
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000017090.
HOGENOM	HBG540956.
OMA	LEYAVPH.
ProtClustDB	PRK00278.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_MYCUA

Accession

Primary (citable) accession number: A0PP28

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program