A0PNU5 (A0PNU5_MYCUA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] PIRNR PIRNR000094
EC=1.3.1.9 PIRNR PIRNR000094

Gene names

Name:	inhA EMBL ABL04014.1
Ordered Locus Names:	MUL_1492

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acyl-[acyl-carrier-protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADH. PIRNR PIRNR000094
Pathway	Lipid metabolism; fatty acid biosynthesis. PIRNR PIRNR000094
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. PIRNR PIRNR000094

Ontologies

Keywords
Biological process	Fatty acid biosynthesis PIRNR PIRNR000094 Lipid synthesis
Ligand	NAD PIRNR PIRNR000094
Molecular function	Oxidoreductase PIRNR PIRNR000094
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	enoyl-[acyl-carrier-protein] reductase (NADH) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	158	1	Proton acceptor By similarity PIRSR PIRSR000094-1

Sequences

	Sequence		Length	Mass (Da)
	A0PNU5 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 69150EF46406FBDE	FASTA	269	28,679
	10 20 30 40 50 60 MAGLLEGKRI LVSGIITDSS IAFHIARVAQ EQGAQLVLTG FDRMRLIQRI VDRLPQKAPL 70 80 90 100 110 120 IELDVQNEEH LASLAGRVTE VIGEGNNLDG VVHSIGFMPQ SGMGINPFFD APYEDVSKGI 130 140 150 160 170 180 HISAYSYASL AKALLPIMNP GGSIVGMDFD PTRAMPAYNW MTVAKSALES VNRFVAREAG 190 200 210 220 230 240 KYGVRSNLVA AGPIRTLAMS AIVGGALGEE AGAQIQLLED GWDQRAPVGW NMKDPTPVAK 250 260 TVCAVLSEWL PATTGDIIFA DGGAHTQLL

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL04014.1.
RefSeq	YP_905485.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PNU5.
SMR	A0PNU5. Positions 2-269.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PNU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000075786; EBMYCP00000073791; EBMYCG00000075781.
GeneID	4552376.
GenomeReviews	Gene locus MUL_1492 in contig CP000325_GR.
KEGG	mul:MUL_1492.
PATRIC	18169878. VBIMycUlc37413_1795.
Organism-specific databases
GenoList	MUL_1492.
CMR	Search...
Phylogenomic databases
eggNOG	COG0623.
GeneTree	EBGT00050000015205.
HOGENOM	HBG750976.
OMA	SSIAFHV.
ProtClustDB	PRK07889.
Family and domain databases
InterPro	IPR014358. Enoyl-ACP_Rdtase_NADH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K11611.
PIRSF	PIRSF000094. Enoyl-ACP_rdct. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0PNU5_MYCUA

Accession

Primary (citable) accession number: A0PNU5

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)