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A0PNL2 (PSD_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:MUL_1386
OrganismMycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]
Taxonomic identifier362242 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Phosphatidylserine decarboxylase beta chain By similarity
PRO_1000026662
Chain209 – 24032Phosphatidylserine decarboxylase alpha chain By similarity
PRO_1000026663

Sites

Site208 – 2092Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2091Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
A0PNL2 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: F97C6703C3C13BEC

FASTA24025,135
        10         20         30         40         50         60 
MARRPRRSDS SSAEPTLSPQ HLLALVRSTI PPIHPAGRPF IAAGLAVAGV GYRHRWARRT 

        70         80         90        100        110        120 
GLLAAGACAG FFRHPPRVPP SRAGAIVAPA DGVICVIDTA APPAELSMGD APLPRVSIFL 

       130        140        150        160        170        180 
SVFDAHVQRA PVSGEVVAVQ HRPGRFGSAD LPAASNDNER NSVRIRTANG AEVVAVQVAG 

       190        200        210        220        230        240 
LVARRIVCDA HVGDKLAIGD TYGLIRFGSR LDTYLPPGTE PVVIVGQRTI AGETILADLP

« Hide

References

[1]"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. expand/collapse author list , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Agy99.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000325 Genomic DNA. Translation: ABL03931.1.
RefSeqYP_905402.1. NC_008611.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA0PNL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000073998; EBMYCP00000072003; EBMYCG00000073993.
GeneID4552536.
GenomeReviewsGene locus MUL_1386 in contig CP000325_GR.
KEGGmul:MUL_1386.
PATRIC18169628. VBIMycUlc37413_1671.

Organism-specific databases

GenoListMUL_1386.
CMRSearch...

Phylogenomic databases

eggNOGCOG0688.
GeneTreeEBGT00050000017584.
HOGENOMHBG541103.
OMAIFMSVFN.
ProtClustDBPRK05305.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_MYCUA
AccessionPrimary (citable) accession number: A0PNL2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 9, 2007
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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