A0PNE9 (A0PNE9_MYCUA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156

Gene names

Name:	aceE EMBL ABL03868.1
Ordered Locus Names:	MUL_1308

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	929 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156
Catalytic activity	Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156
Cofactor	Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Ontologies

Keywords
Ligand	Pyruvate PIRNR PIRNR000156 EMBL ABL03868.1 Thiamine pyrophosphate PIRNR PIRNR000156
Molecular function	Oxidoreductase PIRNR PIRNR000156
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	pyruvate dehydrogenase (acetyl-transferring) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0PNE9 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 1AC454E3CEFEC4FD	FASTA	929	103,366
	10 20 30 40 50 60 MTTEFVRHDL AKTSSSASEP DRVRVIREGV ASYLPDIDPE ETSEWLESFD ALLEHSGPAR 70 80 90 100 110 120 ARYLMLRLLE RAGEQRVAIP SLTSTDYVNT IPTELEPWFP GDEDVERRYR TWIRWNAAIM 130 140 150 160 170 180 VHRAQRPGVG VGGHISTYAS SAALYEVGFN HFFRGKSHPG GGDQVFIQGH ASPGIYARAF 190 200 210 220 230 240 LEGRLSADQL DGFRQEHSHP GGGLPSYPHP RLMPDFWEFP TVSMGLGPLN AIYQARFNHY 250 260 270 280 290 300 LHDRGIKDTS DQHVWCFLGD GEMDEPESRG LAHMGALEGL DNLTFVINCN LQRLDGPVRG 310 320 330 340 350 360 NGKIIQELES FFRGAGWNVI KVVWGREWDA LLHADRDGAL VNLMNSTPDG DYQTYKANDG 370 380 390 400 410 420 AYVRDHFFGR DPRTKALVAN MSDQEIWNLK RGGHDYRKVY AAYRAAVDHK GQPTVILAKT 430 440 450 460 470 480 IKGYSLGAHF QGRNATHQMK KLALADLKRF RDSMRIPVSD AQLDEDPYLP PYYHPGSDAP 490 500 510 520 530 540 EIRYMLDRRR TLGGFLPERP TKAKTLTLPG PDAYKVLKKG SGQQEVATTM ALVRTFKELL 550 560 570 580 590 600 RDKNIGNRIV PIIPDEARTF GMDSWFPSLK IYNRNGQLYT AVDAELMLAY KESHVGQILH 610 620 630 640 650 660 EGINEAGSVG SFTAAGTSYA THNEPMIPIY IFYSMFGFQR TGDSFWAAAD QMARGFVLGA 670 680 690 700 710 720 TAGRTTLTGE GLQHADGHSL LLAATNPAVV SYDPAFAYEL AYIIENGLSR MFGENPENIY 730 740 750 760 770 780 FYITVYNEPY VQPAEPENFD PEGVLRGMYR YRAATKQCAH KAQLLASGVS MPDALKAAQM 790 800 810 820 830 840 LADEWDVATD VWSVTSWSEL NRDGVSVERH RLRHPGEPAG VAYVTTALEG TSGPVVAVSD 850 860 870 880 890 900 WMRAVPEQIR PWVPGTYVTL GTDGFGFSNT RPAARRYFNT DAESQVVAVL EALARDGEID 910 920 ESMAVTAARQ YRIDDVQAAP KQTSDSGVA

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL03868.1.
RefSeq	YP_905339.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PNE9.
SMR	A0PNE9. Positions 85-921.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PNE9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000075869; EBMYCP00000073874; EBMYCG00000075864.
GeneID	4550721.
GenomeReviews	Gene locus MUL_1308 in contig CP000325_GR.
KEGG	mul:MUL_1308.
PATRIC	18169450. VBIMycUlc37413_1582.
Organism-specific databases
GenoList	MUL_1308.
CMR	Search...
Phylogenomic databases
eggNOG	COG2609.
GeneTree	EBGT00050000016271.
HOGENOM	HBG289271.
OMA	FRQEKSH.
PhylomeDB	A0PNE9.
ProtClustDB	PRK09405.
Family and domain databases
InterPro	IPR004660. 2-oxoA_DH_E1. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K00163.
PANTHER	PTHR11624:SF37. PTHR11624:SF37. 1 hit.
Pfam	PF00456. Transketolase_N. 1 hit. [Graphical view]
PIRSF	PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00759. AceE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0PNE9_MYCUA

Accession

Primary (citable) accession number: A0PNE9

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)