Reviewed, UniProtKB/Swiss-Prot A0PN13 (GABD1_MYCUA)

Names and origin

Protein names

Recommended name:
    Succinate-semialdehyde dehydrogenase [NADP+] 1
      Short name=SSADH 1
      Short name=SSDH 1
    EC=1.2.1.16

Gene names

Name:	gabD1
Ordered Locus Names:	MUL_1153

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.
Catalytic activity	Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Succinate-semialdehyde dehydrogenase [NADP+] 1		PRO_0000310707
Regions
	Nucleotide binding	210 – 215	6	NAD or NADP By similarity
Sites
	Active site	232	1	By similarity
	Active site	266	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A0PN13-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: FC438444970FDF85	FASTA	458	48,528
	10 20 30 40 50 60 MPIATTNPAT GETVKTFTAA SNDEVDAAIA RAYARFQDYR RNTTFAQRAE WAHATADLIE 70 80 90 100 110 120 AEADQTAALM TLEMGKTIAS AKAEVLKSAK GFRYYADNAA ALLADEPADA GKVGASQAYT 130 140 150 160 170 180 RYQPLGVVLA VMPWNFPLWQ AGRFAAPALM AGNVGLLKHA SNVPQSALYL ADVIARAGFP 190 200 210 220 230 240 DGCFQTLLVS ASAVEGILRD PRVAAATLTG SEPAGQSVGA IAGDEIKPTV LELGGSDPFI 250 260 270 280 290 300 VMPSADLDKA VSTAVTGRVQ NNGQSCIAAK RFIAHADIYD AFVDKFVEQM SALTVGDPTD 310 320 330 340 350 360 PQTQVGPLAT EQSRDEIAQQ VDDAAAAGAV IRCGGKPLAG PGWYYPPTVI TDITKDMNLY 370 380 390 400 410 420 TEEVFGPVAS VYRAADIDEA IEIANATTFG LGSNAWTQDE AEQRRFINDI EAGQVFINGM 430 440 450 TVSYPELPFG GIKRSGYGRE LAGHGIREFC NIKTVWVG

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000325 Genomic DNA. Translation: ABL03732.1.
RefSeq	YP_905203.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4554025.
GenomeReviews	Gene locus MUL_1153 in contig CP000325_GR.
KEGG	mul:MUL_1153.
Organism-specific databases
BuruList	MUL_1153.
CMR	Search...
Phylogenomic databases
OMA	A0PN13. VPQSALY.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD1_MYCUA

Accession

Primary (citable) accession number: A0PN13

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)