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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106S-adenosyl-L-methionineUniRule annotation1
Binding sitei131S-adenosyl-L-methionineUniRule annotation1
Binding sitei160S-adenosyl-L-methionineUniRule annotation1
Active sitei183By similarity1
Binding sitei183S-adenosyl-L-methionineUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei219SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:MUL_1098
OrganismiMycobacterium ulcerans (strain Agy99)
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000765 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002881841 – 278tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST278

Proteomic databases

PRIDEiA0PMW8

Structurei

3D structure databases

ProteinModelPortaliA0PMW8
SMRiA0PMW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 259Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000073968
KOiK03439
OMAiPDPWHKS
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

A0PMW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHDGPMHVQ PGVGLQSDTS SSTGTGSGPA DEPEAEKSAW GYLPPTAFRS
60 70 80 90 100
RHSALSSIQQ QTWERRWPQL GRQATAHSQP SARGHEPIDP IDARAWFGRE
110 120 130 140 150
APVVLEIGCG SGTSTLAMAQ AEPNVDVIAV EVYRRGLAQL LCAIDRADLQ
160 170 180 190 200
RINIRLIRGN GIDVLRDLIA PESLTGVRVF FPDPWPKARH HKRRLIQPST
210 220 230 240 250
VVLIADRLLP GGVFHAATDH PGYAEHIIAA GDAEPALARV DPGVDSLPVS
260 270
VVRPTTKYEM KAHNAGSSIN ELIWKKQR
Length:278
Mass (Da):30,283
Last modified:January 9, 2007 - v1
Checksum:iB5B8C3B01B8A7630
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA Translation: ABL03687.1

Genome annotation databases

EnsemblBacteriaiABL03687; ABL03687; MUL_1098
KEGGimul:MUL_1098

Similar proteinsi

Entry informationi

Entry nameiTRMB_MYCUA
AccessioniPrimary (citable) accession number: A0PMW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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