A0PMI8 (A0PMI8_MYCUA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Pyrroline-5-carboxylate dehydrogenase, RocA EMBL ABL03557.1

Gene names

Name:	rocA EMBL ABL03557.1
Ordered Locus Names:	MUL_0932

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RuleBase RU003345

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU003344
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: InterPro
Molecular function	1-pyrroline-5-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0PMI8 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 360F76C53C2BF8EB	FASTA	560	60,294
	10 20 30 40 50 60 MSDRLIDSCL PAGMLAGMDA ITQVPIPANE PVHSYAPHSP ERSRLKSELI ALAQQPIDLP 70 80 90 100 110 120 HVIGGKHRMG DGERIDVVQP HRHAERLGTL TNAVHADATA AIEAAMAAKN GWAAMPFDER 130 140 150 160 170 180 AGVFLRAADL LAGPWREKIA AATMLGQSKS AYQAEIDAPC ELVDFWRFNV AFTRQILDQQ 190 200 210 220 230 240 PVSAKGEWNR TDHRPLEGFV YAITPFNFTA IAANLPTAPA LMGNTVVWKP SVTQTLAAYL 250 260 270 280 290 300 TMQALEAAGL PPGVINLVTG DGLAVSDVAL TDPRLAGIHF TGSTATFQHL WQQVGANIAS 310 320 330 340 350 360 YQSYPRLVGE TGGKDFVVAH SSARPEVVAT ALIRGAFEYQ GQKCSAASRA FIPHSVWQQM 370 380 390 400 410 420 GDTFLDTAAG LKYGDITDLS NFGGALIDRR AFIKNVDAIE RAKGAAGVTI AVGGEYDDSV 430 440 450 460 470 480 GYFVRPTALL SDDPTDESFA TEYFGPVLSL HVYPDDQYER ILDVIDTGSR YALTGAVIAD 490 500 510 520 530 540 DRNAVLTAQN RLRFAAGNFY INDKPTGAVV GRQPFGGSRG SGTNDKAGSP QNLLRWTSTR 550 560 TIKETFVPAT DHTYPHMESD

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL03557.1.
RefSeq	YP_905028.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PMI8.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PMI8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000073254; EBMYCP00000071259; EBMYCG00000073249.
GeneID	4551655.
GenomeReviews	Gene locus MUL_0932 in contig CP000325_GR.
KEGG	mul:MUL_0932.
PATRIC	18168591. VBIMycUlc37413_1157.
Organism-specific databases
GenoList	MUL_0932.
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
GeneTree	EBGT00050000015660.
HOGENOM	HBG752218.
OMA	CELVDFW.
PhylomeDB	A0PMI8.
ProtClustDB	CLSK871904.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR005931. Delta1-pyrroline-5-COlate_DH-1. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00294.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01236. D1pyr5carbox1. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A0PMI8_MYCUA

Accession

Primary (citable) accession number: A0PMI8

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)