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Protein

Glutamate decarboxylase

Gene

gadB

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadBImported
Ordered Locus Names:MUL_0878Imported
OrganismiMycobacterium ulcerans (strain Agy99)Imported
Taxonomic identifieri362242 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000765 Componenti: Chromosome

Organism-specific databases

GenoListiMUL_0878.

Interactioni

Protein-protein interaction databases

STRINGi362242.MUL_0878.

Structurei

3D structure databases

ProteinModelPortaliA0PME1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PME1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSHSSVPA HSIAPAYTGR LFTAPVPALR LPEESMDPEA AYRFIHDELM
60 70 80 90 100
LDGSSRLNLA TFVTTWMDPE AGKLMAETFD KNMIDKDEYP ATAAIETRCV
110 120 130 140 150
SMVADLFHAE GLRDDDPSSA TGVSTIGSSE AVMLGGLAMK WRWRQKVGKD
160 170 180 190 200
WKGRTPNLVM GSNVQVVWEK FCRYFDVEPR YLPMEKGRYV ITPEQVVDAV
210 220 230 240 250
DEDTFGVVAI LGTTYTGELE PVAEICAALD RLAAGGGVDV PVHVDAASGG
260 270 280 290 300
FVVPFLHPDL KWDFRLPRVV SINVSGHKYG LTYPGVGFVV WRSPEYLPED
310 320 330 340 350
LVFRVNYLGG DMPTFTLNFS RPGNQVVGQY YNFLRLGREG YINVMQALSE
360 370 380 390 400
TARWLSAQLR EVDHCELIAD GSAIPVVAFR LAGDRGYTEF DLSHELRTFG
410 420 430 440 450
WQVPAYTMPD NATDVSVLRI VVREGLSADM ARALHDDAVT SLRTLDKVKP
460
GGNYDGQHFA H
Length:461
Mass (Da):51,052
Last modified:January 9, 2007 - v1
Checksum:iA0334841DA0E1BA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL03510.1.
RefSeqiWP_011739133.1. NC_008611.1.
YP_904981.1. NC_008611.1.

Genome annotation databases

EnsemblBacteriaiABL03510; ABL03510; MUL_0878.
GeneIDi4553783.
KEGGimul:MUL_0878.
PATRICi18168460. VBIMycUlc37413_1092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000325 Genomic DNA. Translation: ABL03510.1.
RefSeqiWP_011739133.1. NC_008611.1.
YP_904981.1. NC_008611.1.

3D structure databases

ProteinModelPortaliA0PME1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362242.MUL_0878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABL03510; ABL03510; MUL_0878.
GeneIDi4553783.
KEGGimul:MUL_0878.
PATRICi18168460. VBIMycUlc37413_1092.

Organism-specific databases

GenoListiMUL_0878.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
    Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
    , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
    Genome Res. 17:192-200(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Agy99Imported.

Entry informationi

Entry nameiA0PME1_MYCUA
AccessioniPrimary (citable) accession number: A0PME1
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.