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A0PME1

- A0PME1_MYCUA

UniProt

A0PME1 - A0PME1_MYCUA

Protein

Glutamate decarboxylase

Gene

gadB

Organism
Mycobacterium ulcerans (strain Agy99)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadBImported
    Ordered Locus Names:MUL_0878Imported
    OrganismiMycobacterium ulcerans (strain Agy99)Imported
    Taxonomic identifieri362242 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000765: Chromosome

    Organism-specific databases

    GenoListiMUL_0878.

    Interactioni

    Protein-protein interaction databases

    STRINGi362242.MUL_0878.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PME1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0076.
    HOGENOMiHOG000070228.
    KOiK01580.
    OMAiPTFQINF.
    OrthoDBiEOG6TFCPW.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0PME1-1 [UniParc]FASTAAdd to Basket

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    MSRSHSSVPA HSIAPAYTGR LFTAPVPALR LPEESMDPEA AYRFIHDELM    50
    LDGSSRLNLA TFVTTWMDPE AGKLMAETFD KNMIDKDEYP ATAAIETRCV 100
    SMVADLFHAE GLRDDDPSSA TGVSTIGSSE AVMLGGLAMK WRWRQKVGKD 150
    WKGRTPNLVM GSNVQVVWEK FCRYFDVEPR YLPMEKGRYV ITPEQVVDAV 200
    DEDTFGVVAI LGTTYTGELE PVAEICAALD RLAAGGGVDV PVHVDAASGG 250
    FVVPFLHPDL KWDFRLPRVV SINVSGHKYG LTYPGVGFVV WRSPEYLPED 300
    LVFRVNYLGG DMPTFTLNFS RPGNQVVGQY YNFLRLGREG YINVMQALSE 350
    TARWLSAQLR EVDHCELIAD GSAIPVVAFR LAGDRGYTEF DLSHELRTFG 400
    WQVPAYTMPD NATDVSVLRI VVREGLSADM ARALHDDAVT SLRTLDKVKP 450
    GGNYDGQHFA H 461
    Length:461
    Mass (Da):51,052
    Last modified:January 9, 2007 - v1
    Checksum:iA0334841DA0E1BA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL03510.1.
    RefSeqiWP_011739133.1. NC_008611.1.
    YP_904981.1. NC_008611.1.

    Genome annotation databases

    EnsemblBacteriaiABL03510; ABL03510; MUL_0878.
    GeneIDi4553783.
    KEGGimul:MUL_0878.
    PATRICi18168460. VBIMycUlc37413_1092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000325 Genomic DNA. Translation: ABL03510.1 .
    RefSeqi WP_011739133.1. NC_008611.1.
    YP_904981.1. NC_008611.1.

    3D structure databases

    ProteinModelPortali A0PME1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362242.MUL_0878.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABL03510 ; ABL03510 ; MUL_0878 .
    GeneIDi 4553783.
    KEGGi mul:MUL_0878.
    PATRICi 18168460. VBIMycUlc37413_1092.

    Organism-specific databases

    GenoListi MUL_0878.

    Phylogenomic databases

    eggNOGi COG0076.
    HOGENOMi HOG000070228.
    KOi K01580.
    OMAi PTFQINF.
    OrthoDBi EOG6TFCPW.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer."
      Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M.
      , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T.
      Genome Res. 17:192-200(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Agy99Imported.

    Entry informationi

    Entry nameiA0PME1_MYCUA
    AccessioniPrimary (citable) accession number: A0PME1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3