A0PLI0 (PUR7_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	MUL_0497

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000018740

Sequences

	Sequence		Length	Mass (Da)
	A0PLI0 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 4454B51D13DDEBF4	FASTA	297	32,717
	10 20 30 40 50 60 MRPQLSDYQH LASGKVRELY RVDDEHLLVV ASDRISAYDY VLDSMIPDKG RILTAMSVFF 70 80 90 100 110 120 FGLVDAPNHL AGPPDDPRIP DEVLGRALVV RQLEMLPVEC VARGYLTGSG LLDYQASGKV 130 140 150 160 170 180 CGIALPPGLV GASKFAEPLF TPATKAELGD HDENISFAQV IETVGGVRAN QLRDRTLQIY 190 200 210 220 230 240 VKAADHALTR GVIIADTKFE FGADRDGNLL LADEIFTPDS SRYWPADEYR AGVVQNSFDK 250 260 270 280 290 QFVRNWLTSA ESGWDRGGDQ PPPPLPDHII EATRERYIEA YERISGLGFG EWIGPGA

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL03199.1.
RefSeq	YP_904670.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PLI0.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PLI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000075759; EBMYCP00000073764; EBMYCG00000075754.
GeneID	4551991.
GenomeReviews	Gene locus MUL_0497 in contig CP000325_GR.
KEGG	mul:MUL_0497.
PATRIC	18167566. VBIMycUlc37413_0657.
Organism-specific databases
GenoList	MUL_0497.
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
GeneTree	EBGT00050000017539.
HOGENOM	HBG555040.
OMA	LTLMDEV.
PhylomeDB	A0PLI0.
ProtClustDB	PRK13961.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_MYCUA

Accession

Primary (citable) accession number: A0PLI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program