A0PLB3 (A0PLB3_MYCUA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370

Gene names

Name:	purM EMBL ABL03132.1
Ordered Locus Names:	MUL_0418

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733
Subcellular location	Cytoplasm By similarity SAAS SAAS004733.
Sequence similarities	Belongs to the AIR synthase family. RuleBase RU004370

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS004733
Cellular component	Cytoplasm SAAS SAAS004733
Ligand	ATP-binding SAAS SAAS004733 Nucleotide-binding
Molecular function	Ligase RuleBase RU004370 SAAS SAAS004733
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0PLB3 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 5E25821F8D4339A4	FASTA	387	40,776
	10 20 30 40 50 60 MRGARVADTG GERRPVAFIA MTDPEKSPES SGRGPASQGV TYAAAGVDIE AGDRAVELFK 70 80 90 100 110 120 PLATRATRPE VRGGLGGFAG LFALRNDYRE PVLAASTDGV GTKLAVAQAM DKHDTVGLDL 130 140 150 160 170 180 VAMVVDDLVV CGAEPLFLQD YIAVGRTVPE RVSAIVSGIA EGCVRAGCAL LGGETAEHPG 190 200 210 220 230 240 LMAPDHYDIS ATGVGVVEAD NVLGPERVKP GDVIIAMGSS GLHSNGYSLA RNVLLEIDRM 250 260 270 280 290 300 NLAGYVEEFG RTLGEELLEP TRIYAKDCLA LTAETHVRTF CHVTGGGLAG NLERVIPHGL 310 320 330 340 350 360 VAEIDRGTWT PAPVFAMIAQ RGRVVREEME KTFNMGVGMI AVVAPEDTDR ALAILTARHL 370 380 DCWVLGTVCK GGKEGPRATL VGQHPRF

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL03132.1.
RefSeq	YP_904603.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PLB3.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PLB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000076291; EBMYCP00000074296; EBMYCG00000076286.
GeneID	4551771.
GenomeReviews	Gene locus MUL_0418 in contig CP000325_GR.
KEGG	mul:MUL_0418.
PATRIC	18167392. VBIMycUlc37413_0572.
Organism-specific databases
GenoList	MUL_0418.
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
GeneTree	EBGT00050000016383.
HOGENOM	HBG531222.
OMA	PENIPRV.
ProtClustDB	PRK05385.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A0PLB3_MYCUA

Accession

Primary (citable) accession number: A0PLB3

Entry history

Integrated into UniProtKB/TrEMBL:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)