A0PKS1 (COAA_MYCUA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	MUL_0189

Organism

Mycobacterium ulcerans (strain Agy99) [Complete proteome] [HAMAP]

Taxonomic identifier

362242 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Pantothenate kinase HAMAP MF_00215		PRO_1000043233
Regions
	Nucleotide binding	97 – 104	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A0PKS1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: BBD034E3A191052E	FASTA	312	35,598
	10 20 30 40 50 60 MSRLSEPSPY VEFDRRQWRA LRMSTPLALT EAELIGLRGL GEQIDLLEVE EVFLPLARLL 70 80 90 100 110 120 HLQVAARQRL FAATAEFLGE PQQNPDRPVP FIIGVAGSVA VGKSTTARVL QALLARWDHH 130 140 150 160 170 180 PRVDLVTTDG FLYPNAELER RNLMHRKGFP ESYNRRALMR FVTSVKSGSD YACAPVYSHL 190 200 210 220 230 240 HYNIIPGAKQ VVRHPDILIL EGLNVLQTGP TLMVSDLFDF SLYVDARIED IEQWYVSRFL 250 260 270 280 290 300 AMRSTAFANP ESHFHHYSAL PDPEAVVAAR EIWRTINRPN LVENILPTRP RATLVLRKDA 310 DHSIKRLRLR KL

References

[1]

"Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer." Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T., Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J., Johnson P.D.R., Davies J.K., Jenkin G.A., Small P.L.C., Jones L.M. , Tekaia F., Laval F., Daffe M., Parkhill J., Cole S.T. Genome Res. 17:192-200(2007) [PubMed: 17210928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Agy99.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000325 Genomic DNA. Translation: ABL02940.1.
RefSeq	YP_904411.1. NC_008611.1.
3D structure databases
ProteinModelPortal	A0PKS1.
SMR	A0PKS1. Positions 5-312.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PKS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000075271; EBMYCP00000073276; EBMYCG00000075266.
GeneID	4551412.
GenomeReviews	Gene locus MUL_0189 in contig CP000325_GR.
KEGG	mul:MUL_0189.
PATRIC	18166851. VBIMycUlc37413_0304.
Organism-specific databases
GenoList	MUL_0189.
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
GeneTree	EBGT00050000016369.
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	A0PKS1.
ProtClustDB	PRK05439.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_MYCUA

Accession

Primary (citable) accession number: A0PKS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 9, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program