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Protein

Palmitoyltransferase ZDHHC22

Gene

Zdhhc22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

  • protein localization to plasma membrane Source: MGI
  • protein palmitoylation Source: MGI

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC22 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 22
Short name:
DHHC-22
Short name:
zDHHC22
Gene namesi
Name:Zdhhc22
Synonyms:Gm262
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2685108. Zdhhc22.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002787721 – 263Palmitoyltransferase ZDHHC22Add BLAST263

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiA0PK84.
PRIDEiA0PK84.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048483.
CleanExiMM_ZDHHC22.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 131DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00730000111268.
HOGENOMiHOG000082400.
HOVERGENiHBG094179.
InParanoidiA0PK84.
KOiK18932.
OMAiHSISQFF.
OrthoDBiEOG091G10XR.
PhylomeDBiA0PK84.
TreeFamiTF342115.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
IPR000731. SSD.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
PS50156. SSD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PK84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALRLLNVV APAYFLCISL VTFVLQLFLF LPSMREDPTA TPLFSPAVLH
60 70 80 90 100
GALFLFLSAN ALGNYVLVIQ NSPDDLGTCQ GTMSQRPQCP PPSTHFCRVC
110 120 130 140 150
SRVTLRHDHH CFFTGNCIGS RNMRNFILFC LYTSLACLYS MVAGVAYISA
160 170 180 190 200
VLSISFAHPL AFLTLLPTSI SQFFSGAVLG SDMFVILMLY LWFAVGLACA
210 220 230 240 250
GFCCHQLLLI LRGQTRYQVR KGMAVRARPW RKNLQEVFGK RWLLGLLVPM
260
FNVGTESSKQ QDK
Length:263
Mass (Da):29,318
Last modified:January 9, 2007 - v1
Checksum:i32DA19CA24F9D60F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC128021 mRNA. Translation: AAI28022.1.
CCDSiCCDS36500.1.
RefSeqiNP_001074412.1. NM_001080943.2.
XP_006515914.1. XM_006515851.2.
XP_006515915.1. XM_006515852.3.
UniGeneiMm.185890.

Genome annotation databases

EnsembliENSMUST00000095521; ENSMUSP00000093177; ENSMUSG00000048483.
GeneIDi238331.
KEGGimmu:238331.
UCSCiuc007oie.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDH22_MOUSE
AccessioniPrimary (citable) accession number: A0PK84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: January 9, 2007
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families