A0PK05 (TMM72_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 72

Alternative name(s):
Kidney-specific secretory protein of 37 kDa

Gene names

Name:	TMEM72
Synonyms:	C10orf127, KSP37

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A0PK05-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A0PK05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Transmembrane protein 72		PRO_0000319055
Regions
	Transmembrane	16 – 36	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	86 – 105	20	Helical; Potential
	Transmembrane	109 – 131	23	Helical; Potential
Natural variations
	Alternative sequence	1 – 118	118	Missing in isoform 2.		VSP_031343

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 37F5996499CA8F65	FASTA	275	29,891
	10 20 30 40 50 60 MQLQVFWTGL EYTCRLLGIT TAAVLIGVGT ETFLQGQFKS LAFYLLFTGA AVSICEGAYF 70 80 90 100 110 120 VAQLLAICFQ CQPGSLADRV REKAHWLGCF QKFLAYLLLS VACFLHPVLV WHVTIPGSML 130 140 150 160 170 180 IITGLAYFLL SKRKKRKAAP EVLASPEQYT DPSSSAVSTT GSGDTEQTYT FHGALKEGPS 190 200 210 220 230 240 SLFIHMKSIL KGTKKPSALQ PPNTLMELSL EPADSLAKKK QVHFEDNLVR IVPSLAEGLD 250 260 270 DGDSEPEETT SDTTPIIPPP QAPLFLSSLT ATGLF
	Isoform 2 [UniParc]. Checksum: ADD507A7DA873754	FASTA	157	16,870
	10 20 30 40 50 60 MLIITGLAYF LLSKRKKRKA APEVLASPEQ YTDPSSSAVS TTGSGDTEQT YTFHGALKEG 70 80 90 100 110 120 PSSLFIHMKS ILKGTKKPSA LQPPNTLMEL SLEPADSLAK KKQVHFEDNL VRIVPSLAEG 130 140 150 LDDGDSEPEE TTSDTTPIIP PPQAPLFLSS LTATGLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TMEM72, a novel transmembranous protein, expressed in distal and collecting tubules." Higuchi T., Katsuya K., Nakanishi S., Orita T., Kobayashi Y., Munger W., Sun H.W., Falk R.J., Jennette J.C., Alcorta D.A., Li H., Yamamoto T., Saito Y., Nakamura M. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL353801 Genomic DNA. Translation: CAI13061.2. AB235418 mRNA. Translation: BAF97794.1. BC127789 mRNA. Translation: AAI27790.1. BC127790 mRNA. Translation: AAI27791.1.
IPI	IPI00783225. IPI00884963.
RefSeq	NP_001116848.1. NM_001123376.1.
UniGene	Hs.292788.
3D structure databases
ProteinModelPortal	A0PK05.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PK05.
Proteomic databases
PRIDE	A0PK05.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000389583; ENSP00000374234; ENSG00000187783.
GeneID	643236.
KEGG	hsa:643236.
NMPDR	fig|9606.3.peg.3832.
UCSC	uc001jbn.2. human. uc009xmm.1. human.
Organism-specific databases
CTD	643236.
GeneCards	GC10P045406.
HGNC	HGNC:31658. TMEM72.
HPA	HPA039894.
neXtProt	NX_A0PK05.
PharmGKB	PA164726549.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000006888.
HOGENOM	HBG280211.
HOVERGEN	HBG094935.
InParanoid	A0PK05.
OMA	QYTDPSS.
OrthoDB	EOG470THZ.
PhylomeDB	A0PK05.
Gene expression databases
Bgee	A0PK05.
CleanEx	HS_TMEM72.
Genevestigator	A0PK05.
Family and domain databases
ProtoNet	Search...
Other
NextBio	114658.

Entry information

Entry name

TMM72_HUMAN

Accession

Primary (citable) accession number: A0PK05
Secondary accession number(s): A1L181, Q5T740

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.