ID   T120B_HUMAN             Reviewed;         339 AA.
AC   A0PK00; A0PK01; B3KX33;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   RecName: Full=Transmembrane protein 120B {ECO:0000305};
GN   Name=TMEM120B {ECO:0000312|HGNC:HGNC:32008};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Necessary for efficient adipogenesis. Does not show ion
CC       channel activity. {ECO:0000250|UniProtKB:Q3TA38}.
CC   -!- SUBUNIT: Heterooligomer with TMEM120A. {ECO:0000250|UniProtKB:Q3TA38}.
CC   -!- INTERACTION:
CC       A0PK00; P20292: ALOX5AP; NbExp=3; IntAct=EBI-10171534, EBI-3904621;
CC       A0PK00; Q68DC2: ANKS6; NbExp=3; IntAct=EBI-10171534, EBI-7054139;
CC       A0PK00; Q6Q788: APOA5; NbExp=3; IntAct=EBI-10171534, EBI-3936819;
CC       A0PK00; Q13520: AQP6; NbExp=3; IntAct=EBI-10171534, EBI-13059134;
CC       A0PK00; O94778: AQP8; NbExp=3; IntAct=EBI-10171534, EBI-19124986;
CC       A0PK00; O60238: BNIP3L; NbExp=3; IntAct=EBI-10171534, EBI-849893;
CC       A0PK00; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10171534, EBI-748961;
CC       A0PK00; P04233-2: CD74; NbExp=3; IntAct=EBI-10171534, EBI-12222807;
CC       A0PK00; P21964: COMT; NbExp=3; IntAct=EBI-10171534, EBI-372265;
CC       A0PK00; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10171534, EBI-18013275;
CC       A0PK00; Q96BA8: CREB3L1; NbExp=5; IntAct=EBI-10171534, EBI-6942903;
CC       A0PK00; Q15125: EBP; NbExp=3; IntAct=EBI-10171534, EBI-3915253;
CC       A0PK00; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10171534, EBI-781551;
CC       A0PK00; O15552: FFAR2; NbExp=3; IntAct=EBI-10171534, EBI-2833872;
CC       A0PK00; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-10171534, EBI-3918971;
CC       A0PK00; Q05329: GAD2; NbExp=3; IntAct=EBI-10171534, EBI-9304251;
CC       A0PK00; P08034: GJB1; NbExp=3; IntAct=EBI-10171534, EBI-17565645;
CC       A0PK00; Q5T7V8: GORAB; NbExp=3; IntAct=EBI-10171534, EBI-3917143;
CC       A0PK00; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10171534, EBI-13345167;
CC       A0PK00; Q9NZD1: GPRC5D; NbExp=3; IntAct=EBI-10171534, EBI-13067820;
CC       A0PK00; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10171534, EBI-11721746;
CC       A0PK00; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-10171534, EBI-1052304;
CC       A0PK00; P38484: IFNGR2; NbExp=3; IntAct=EBI-10171534, EBI-3905457;
CC       A0PK00; P16871: IL7R; NbExp=3; IntAct=EBI-10171534, EBI-80490;
CC       A0PK00; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10171534, EBI-10266796;
CC       A0PK00; Q9HDC5: JPH1; NbExp=3; IntAct=EBI-10171534, EBI-465137;
CC       A0PK00; P48051: KCNJ6; NbExp=3; IntAct=EBI-10171534, EBI-12017638;
CC       A0PK00; O43300: LRRTM2; NbExp=3; IntAct=EBI-10171534, EBI-18096461;
CC       A0PK00; O14880: MGST3; NbExp=3; IntAct=EBI-10171534, EBI-724754;
CC       A0PK00; Q9Y676: MRPS18B; NbExp=3; IntAct=EBI-10171534, EBI-750085;
CC       A0PK00; P15941-11: MUC1; NbExp=3; IntAct=EBI-10171534, EBI-17263240;
CC       A0PK00; Q6IBW4-4: NCAPH2; NbExp=3; IntAct=EBI-10171534, EBI-10247000;
CC       A0PK00; Q9BRK0: REEP2; NbExp=3; IntAct=EBI-10171534, EBI-11337973;
CC       A0PK00; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10171534, EBI-7545592;
CC       A0PK00; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-10171534, EBI-10192441;
CC       A0PK00; Q6ZMZ0: RNF19B; NbExp=3; IntAct=EBI-10171534, EBI-2466594;
CC       A0PK00; Q99942: RNF5; NbExp=3; IntAct=EBI-10171534, EBI-348482;
CC       A0PK00; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-10171534, EBI-17247926;
CC       A0PK00; Q8IVP1: SH3GL3; NbExp=3; IntAct=EBI-10171534, EBI-6503765;
CC       A0PK00; Q14973: SLC10A1; NbExp=3; IntAct=EBI-10171534, EBI-3923031;
CC       A0PK00; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10171534, EBI-18159983;
CC       A0PK00; Q8NDX2-2: SLC17A8; NbExp=3; IntAct=EBI-10171534, EBI-17249797;
CC       A0PK00; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-10171534, EBI-17595455;
CC       A0PK00; P43003: SLC1A3; NbExp=3; IntAct=EBI-10171534, EBI-359038;
CC       A0PK00; P27105: STOM; NbExp=3; IntAct=EBI-10171534, EBI-1211440;
CC       A0PK00; P32856-2: STX2; NbExp=3; IntAct=EBI-10171534, EBI-11956649;
CC       A0PK00; Q96MV1: TLCD4; NbExp=3; IntAct=EBI-10171534, EBI-12947623;
CC       A0PK00; Q8IV31: TMEM139; NbExp=3; IntAct=EBI-10171534, EBI-7238458;
CC       A0PK00; Q96AN5: TMEM143; NbExp=3; IntAct=EBI-10171534, EBI-13342951;
CC       A0PK00; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-10171534, EBI-8638294;
CC       A0PK00; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-10171534, EBI-11742770;
CC       A0PK00; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-10171534, EBI-12345267;
CC       A0PK00; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10171534, EBI-6447886;
CC       A0PK00; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-10171534, EBI-12837904;
CC   -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC       {ECO:0000250|UniProtKB:Q3TA38}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK126568; BAG54345.1; -; mRNA.
DR   EMBL; BC127768; AAI27769.1; -; mRNA.
DR   EMBL; BC127769; AAI27770.1; -; mRNA.
DR   CCDS; CCDS41852.1; -.
DR   RefSeq; NP_001074294.2; NM_001080825.2.
DR   RefSeq; XP_016874342.1; XM_017018853.1.
DR   PDB; 7F73; EM; 4.00 A; A/B=1-339.
DR   PDBsum; 7F73; -.
DR   AlphaFoldDB; A0PK00; -.
DR   EMDB; EMD-31484; -.
DR   SMR; A0PK00; -.
DR   BioGRID; 126849; 116.
DR   IntAct; A0PK00; 69.
DR   STRING; 9606.ENSP00000404991; -.
DR   iPTMnet; A0PK00; -.
DR   PhosphoSitePlus; A0PK00; -.
DR   SwissPalm; A0PK00; -.
DR   BioMuta; TMEM120B; -.
DR   EPD; A0PK00; -.
DR   jPOST; A0PK00; -.
DR   MassIVE; A0PK00; -.
DR   MaxQB; A0PK00; -.
DR   PaxDb; 9606-ENSP00000404991; -.
DR   PeptideAtlas; A0PK00; -.
DR   ProteomicsDB; 76; -.
DR   Pumba; A0PK00; -.
DR   Antibodypedia; 2742; 45 antibodies from 15 providers.
DR   DNASU; 144404; -.
DR   Ensembl; ENST00000342607.10; ENSP00000345152.6; ENSG00000188735.13.
DR   Ensembl; ENST00000449592.7; ENSP00000404991.2; ENSG00000188735.13.
DR   GeneID; 144404; -.
DR   KEGG; hsa:144404; -.
DR   MANE-Select; ENST00000449592.7; ENSP00000404991.2; NM_001080825.2; NP_001074294.2.
DR   UCSC; uc001ubc.5; human.
DR   AGR; HGNC:32008; -.
DR   CTD; 144404; -.
DR   DisGeNET; 144404; -.
DR   GeneCards; TMEM120B; -.
DR   HGNC; HGNC:32008; TMEM120B.
DR   HPA; ENSG00000188735; Tissue enhanced (brain).
DR   MIM; 616551; gene.
DR   neXtProt; NX_A0PK00; -.
DR   OpenTargets; ENSG00000188735; -.
DR   PharmGKB; PA162405862; -.
DR   VEuPathDB; HostDB:ENSG00000188735; -.
DR   eggNOG; KOG4758; Eukaryota.
DR   GeneTree; ENSGT00390000007848; -.
DR   HOGENOM; CLU_048749_1_1_1; -.
DR   InParanoid; A0PK00; -.
DR   OMA; ESCLKDW; -.
DR   OrthoDB; 314124at2759; -.
DR   PhylomeDB; A0PK00; -.
DR   TreeFam; TF313552; -.
DR   PathwayCommons; A0PK00; -.
DR   SignaLink; A0PK00; -.
DR   BioGRID-ORCS; 144404; 10 hits in 1159 CRISPR screens.
DR   ChiTaRS; TMEM120B; human.
DR   GenomeRNAi; 144404; -.
DR   Pharos; A0PK00; Tdark.
DR   PRO; PR:A0PK00; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; A0PK00; Protein.
DR   Bgee; ENSG00000188735; Expressed in right hemisphere of cerebellum and 135 other cell types or tissues.
DR   ExpressionAtlas; A0PK00; baseline and differential.
DR   GO; GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.
DR   GO; GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
DR   GO; GO:0051291; P:protein heterooligomerization; ISS:UniProtKB.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433:SF2; TRANSMEMBRANE PROTEIN 120B; 1.
DR   PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR   Pfam; PF07851; TMPIT; 1.
DR   Genevisible; A0PK00; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Coiled coil; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..339
FT                   /note="Transmembrane protein 120B"
FT                   /id="PRO_0000309529"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          1..77
FT                   /evidence="ECO:0000255"
FT   CONFLICT        92
FT                   /note="D -> N (in Ref. 2; AAI27770)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   339 AA;  40246 MW;  15A08B563ED261D3 CRC64;
     MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ KKHLKDLKLT
     LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK NGLYLNLVLG NVNVTLLSNQ
     AKFAYKDEYE KFKLYLTIIL LLGAVACRFV LHYRVTDEVF NFLLVWYYCT LTIRESILIS
     NGSRIKGWWV SHHYVSTFLS GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC
     LYRLRALGER NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
     WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
//