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A0PK00 (T120B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 120B
Gene names
Name:TMEM120B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM120 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Transmembrane protein 120B
PRO_0000309529

Regions

Transmembrane102 – 12423Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane159 – 17921Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane270 – 29021Helical; Potential
Transmembrane302 – 32221Helical; Potential
Coiled coil1 – 7777 Potential

Experimental info

Sequence conflict921D → N in AAI27770. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A0PK00 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 15A08B563ED261D3

FASTA33940,246
        10         20         30         40         50         60 
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ KKHLKDLKLT 

        70         80         90        100        110        120 
LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK NGLYLNLVLG NVNVTLLSNQ 

       130        140        150        160        170        180 
AKFAYKDEYE KFKLYLTIIL LLGAVACRFV LHYRVTDEVF NFLLVWYYCT LTIRESILIS 

       190        200        210        220        230        240 
NGSRIKGWWV SHHYVSTFLS GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC 

       250        260        270        280        290        300 
LYRLRALGER NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE 

       310        320        330 
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK126568 mRNA. Translation: BAG54345.1.
BC127768 mRNA. Translation: AAI27769.1.
BC127769 mRNA. Translation: AAI27770.1.
CCDSCCDS41852.1.
RefSeqNP_001074294.2. NM_001080825.2.
UniGeneHs.644504.

3D structure databases

ProteinModelPortalA0PK00.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126849. 1 interaction.
STRING9606.ENSP00000345152.

PTM databases

PhosphoSiteA0PK00.

Proteomic databases

MaxQBA0PK00.
PaxDbA0PK00.
PRIDEA0PK00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342607; ENSP00000345152; ENSG00000188735.
ENST00000449592; ENSP00000404991; ENSG00000188735.
GeneID144404.
KEGGhsa:144404.
UCSCuc001ubc.4. human.

Organism-specific databases

CTD144404.
GeneCardsGC12P122150.
HGNCHGNC:32008. TMEM120B.
HPAHPA014066.
neXtProtNX_A0PK00.
PharmGKBPA162405862.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG329433.
HOGENOMHOG000267032.
HOVERGENHBG108532.
InParanoidA0PK00.
OMAHKECKEW.
OrthoDBEOG790G18.
PhylomeDBA0PK00.
TreeFamTF313552.

Gene expression databases

ArrayExpressA0PK00.
BgeeA0PK00.
GenevestigatorA0PK00.

Family and domain databases

InterProIPR012926. TMPIT.
[Graphical view]
PANTHERPTHR21433. PTHR21433. 1 hit.
PfamPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM120B. human.
GenomeRNAi144404.
NextBio84906.
PROA0PK00.

Entry information

Entry nameT120B_HUMAN
AccessionPrimary (citable) accession number: A0PK00
Secondary accession number(s): A0PK01, B3KX33
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM