Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 120B

Gene

TMEM120B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for efficient adipogenesis.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000188735.12
HGNCiHGNC:32008 TMEM120B
MIMi616551 gene
neXtProtiNX_A0PK00

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi144404
OpenTargetsiENSG00000188735
PharmGKBiPA162405862

Polymorphism and mutation databases

BioMutaiTMEM120B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095291 – 339Transmembrane protein 120BAdd BLAST339

Proteomic databases

MaxQBiA0PK00
PaxDbiA0PK00
PRIDEiA0PK00
ProteomicsDBi76

PTM databases

iPTMnetiA0PK00
PhosphoSitePlusiA0PK00
SwissPalmiA0PK00

Expressioni

Gene expression databases

BgeeiENSG00000188735
ExpressionAtlasiA0PK00 baseline and differential
GenevisibleiA0PK00 HS

Organism-specific databases

HPAiHPA014066

Interactioni

Subunit structurei

Heterooligomer with TMEM120A.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10171534,EBI-748961

Protein-protein interaction databases

BioGridi126849, 30 interactors
IntActiA0PK00, 10 interactors
STRINGi9606.ENSP00000345152

Structurei

3D structure databases

ProteinModelPortaliA0PK00
SMRiA0PK00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 77Sequence analysisAdd BLAST77

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4758 Eukaryota
ENOG410XT6G LUCA
GeneTreeiENSGT00390000007848
HOGENOMiHOG000267032
HOVERGENiHBG108532
InParanoidiA0PK00
OMAiQNIFFDM
OrthoDBiEOG091G0BVA
PhylomeDBiA0PK00
TreeFamiTF313552

Family and domain databases

InterProiView protein in InterPro
IPR012926 TMPIT
PANTHERiPTHR21433 PTHR21433, 1 hit
PfamiView protein in Pfam
PF07851 TMPIT, 1 hit

Sequencei

Sequence statusi: Complete.

A0PK00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ
60 70 80 90 100
KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK
110 120 130 140 150
NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV
160 170 180 190 200
LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS
210 220 230 240 250
GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER
260 270 280 290 300
NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
310 320 330
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
Length:339
Mass (Da):40,246
Last modified:January 9, 2007 - v1
Checksum:i15A08B563ED261D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92D → N in AAI27770 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126568 mRNA Translation: BAG54345.1
BC127768 mRNA Translation: AAI27769.1
BC127769 mRNA Translation: AAI27770.1
CCDSiCCDS41852.1
RefSeqiNP_001074294.2, NM_001080825.2
XP_016874342.1, XM_017018853.1
UniGeneiHs.644504
Hs.744740

Genome annotation databases

EnsembliENST00000342607; ENSP00000345152; ENSG00000188735
ENST00000449592; ENSP00000404991; ENSG00000188735
GeneIDi144404
KEGGihsa:144404
UCSCiuc001ubc.5 human

Similar proteinsi

Entry informationi

Entry nameiT120B_HUMAN
AccessioniPrimary (citable) accession number: A0PK00
Secondary accession number(s): A0PK01, B3KX33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: June 20, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health