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A0PK00

- T120B_HUMAN

UniProt

A0PK00 - T120B_HUMAN

Protein

Transmembrane protein 120B

Gene

TMEM120B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 120B
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:32008. TMEM120B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405862.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Transmembrane protein 120BPRO_0000309529Add
    BLAST

    Proteomic databases

    MaxQBiA0PK00.
    PaxDbiA0PK00.
    PRIDEiA0PK00.

    PTM databases

    PhosphoSiteiA0PK00.

    Expressioni

    Gene expression databases

    ArrayExpressiA0PK00.
    BgeeiA0PK00.
    GenevestigatoriA0PK00.

    Organism-specific databases

    HPAiHPA014066.

    Interactioni

    Protein-protein interaction databases

    BioGridi126849. 1 interaction.
    STRINGi9606.ENSP00000345152.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PK00.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei102 – 12423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei132 – 15221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei270 – 29021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 7777Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TMEM120 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG329433.
    HOGENOMiHOG000267032.
    HOVERGENiHBG108532.
    InParanoidiA0PK00.
    OMAiHKECKEW.
    OrthoDBiEOG790G18.
    PhylomeDBiA0PK00.
    TreeFamiTF313552.

    Family and domain databases

    InterProiIPR012926. TMPIT.
    [Graphical view]
    PANTHERiPTHR21433. PTHR21433. 1 hit.
    PfamiPF07851. TMPIT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0PK00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ    50
    KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK 100
    NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV 150
    LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS 200
    GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER 250
    NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE 300
    WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP 339
    Length:339
    Mass (Da):40,246
    Last modified:January 9, 2007 - v1
    Checksum:i15A08B563ED261D3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921D → N in AAI27770. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126568 mRNA. Translation: BAG54345.1.
    BC127768 mRNA. Translation: AAI27769.1.
    BC127769 mRNA. Translation: AAI27770.1.
    CCDSiCCDS41852.1.
    RefSeqiNP_001074294.2. NM_001080825.2.
    UniGeneiHs.644504.

    Genome annotation databases

    EnsembliENST00000342607; ENSP00000345152; ENSG00000188735.
    ENST00000449592; ENSP00000404991; ENSG00000188735.
    GeneIDi144404.
    KEGGihsa:144404.
    UCSCiuc001ubc.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126568 mRNA. Translation: BAG54345.1 .
    BC127768 mRNA. Translation: AAI27769.1 .
    BC127769 mRNA. Translation: AAI27770.1 .
    CCDSi CCDS41852.1.
    RefSeqi NP_001074294.2. NM_001080825.2.
    UniGenei Hs.644504.

    3D structure databases

    ProteinModelPortali A0PK00.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126849. 1 interaction.
    STRINGi 9606.ENSP00000345152.

    PTM databases

    PhosphoSitei A0PK00.

    Proteomic databases

    MaxQBi A0PK00.
    PaxDbi A0PK00.
    PRIDEi A0PK00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342607 ; ENSP00000345152 ; ENSG00000188735 .
    ENST00000449592 ; ENSP00000404991 ; ENSG00000188735 .
    GeneIDi 144404.
    KEGGi hsa:144404.
    UCSCi uc001ubc.4. human.

    Organism-specific databases

    CTDi 144404.
    GeneCardsi GC12P122150.
    HGNCi HGNC:32008. TMEM120B.
    HPAi HPA014066.
    neXtProti NX_A0PK00.
    PharmGKBi PA162405862.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG329433.
    HOGENOMi HOG000267032.
    HOVERGENi HBG108532.
    InParanoidi A0PK00.
    OMAi HKECKEW.
    OrthoDBi EOG790G18.
    PhylomeDBi A0PK00.
    TreeFami TF313552.

    Miscellaneous databases

    ChiTaRSi TMEM120B. human.
    GenomeRNAii 144404.
    NextBioi 84906.
    PROi A0PK00.

    Gene expression databases

    ArrayExpressi A0PK00.
    Bgeei A0PK00.
    Genevestigatori A0PK00.

    Family and domain databases

    InterProi IPR012926. TMPIT.
    [Graphical view ]
    PANTHERi PTHR21433. PTHR21433. 1 hit.
    Pfami PF07851. TMPIT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiT120B_HUMAN
    AccessioniPrimary (citable) accession number: A0PK00
    Secondary accession number(s): A0PK01, B3KX33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3