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Protein

Transmembrane protein 120B

Gene

TMEM120B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:32008. TMEM120B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei102 – 12423HelicalSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence AnalysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence AnalysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence AnalysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405862.

Polymorphism and mutation databases

BioMutaiTMEM120B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Transmembrane protein 120BPRO_0000309529Add
BLAST

Proteomic databases

MaxQBiA0PK00.
PaxDbiA0PK00.
PRIDEiA0PK00.

PTM databases

PhosphoSiteiA0PK00.

Expressioni

Gene expression databases

BgeeiA0PK00.
ExpressionAtlasiA0PK00. baseline and differential.
GenevisibleiA0PK00. HS.

Organism-specific databases

HPAiHPA014066.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10171534,EBI-748961

Protein-protein interaction databases

BioGridi126849. 6 interactions.
IntActiA0PK00. 1 interaction.
STRINGi9606.ENSP00000345152.

Structurei

3D structure databases

ProteinModelPortaliA0PK00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 7777Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329433.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiA0PK00.
OMAiHKECKEW.
OrthoDBiEOG790G18.
PhylomeDBiA0PK00.
TreeFamiTF313552.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PK00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ
60 70 80 90 100
KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK
110 120 130 140 150
NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV
160 170 180 190 200
LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS
210 220 230 240 250
GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER
260 270 280 290 300
NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
310 320 330
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
Length:339
Mass (Da):40,246
Last modified:January 9, 2007 - v1
Checksum:i15A08B563ED261D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921D → N in AAI27770 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126568 mRNA. Translation: BAG54345.1.
BC127768 mRNA. Translation: AAI27769.1.
BC127769 mRNA. Translation: AAI27770.1.
CCDSiCCDS41852.1.
RefSeqiNP_001074294.2. NM_001080825.2.
XP_011536255.1. XM_011537953.1.
XP_011536256.1. XM_011537954.1.
UniGeneiHs.644504.
Hs.744740.

Genome annotation databases

EnsembliENST00000342607; ENSP00000345152; ENSG00000188735.
ENST00000449592; ENSP00000404991; ENSG00000188735.
GeneIDi144404.
KEGGihsa:144404.
UCSCiuc001ubc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126568 mRNA. Translation: BAG54345.1.
BC127768 mRNA. Translation: AAI27769.1.
BC127769 mRNA. Translation: AAI27770.1.
CCDSiCCDS41852.1.
RefSeqiNP_001074294.2. NM_001080825.2.
XP_011536255.1. XM_011537953.1.
XP_011536256.1. XM_011537954.1.
UniGeneiHs.644504.
Hs.744740.

3D structure databases

ProteinModelPortaliA0PK00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126849. 6 interactions.
IntActiA0PK00. 1 interaction.
STRINGi9606.ENSP00000345152.

PTM databases

PhosphoSiteiA0PK00.

Polymorphism and mutation databases

BioMutaiTMEM120B.

Proteomic databases

MaxQBiA0PK00.
PaxDbiA0PK00.
PRIDEiA0PK00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342607; ENSP00000345152; ENSG00000188735.
ENST00000449592; ENSP00000404991; ENSG00000188735.
GeneIDi144404.
KEGGihsa:144404.
UCSCiuc001ubc.4. human.

Organism-specific databases

CTDi144404.
GeneCardsiGC12P122150.
HGNCiHGNC:32008. TMEM120B.
HPAiHPA014066.
neXtProtiNX_A0PK00.
PharmGKBiPA162405862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG329433.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiA0PK00.
OMAiHKECKEW.
OrthoDBiEOG790G18.
PhylomeDBiA0PK00.
TreeFamiTF313552.

Miscellaneous databases

ChiTaRSiTMEM120B. human.
GenomeRNAii144404.
NextBioi84906.
PROiA0PK00.

Gene expression databases

BgeeiA0PK00.
ExpressionAtlasiA0PK00. baseline and differential.
GenevisibleiA0PK00. HS.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiT120B_HUMAN
AccessioniPrimary (citable) accession number: A0PK00
Secondary accession number(s): A0PK01, B3KX33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: July 22, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.