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A0PK00

- T120B_HUMAN

UniProt

A0PK00 - T120B_HUMAN

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Protein
Transmembrane protein 120B
Gene
TMEM120B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:32008. TMEM120B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei102 – 12423Helical; Reviewed prediction
Add
BLAST
Transmembranei132 – 15221Helical; Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Transmembranei270 – 29021Helical; Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Transmembrane protein 120B
PRO_0000309529Add
BLAST

Proteomic databases

MaxQBiA0PK00.
PaxDbiA0PK00.
PRIDEiA0PK00.

PTM databases

PhosphoSiteiA0PK00.

Expressioni

Gene expression databases

ArrayExpressiA0PK00.
BgeeiA0PK00.
GenevestigatoriA0PK00.

Organism-specific databases

HPAiHPA014066.

Interactioni

Protein-protein interaction databases

BioGridi126849. 1 interaction.
STRINGi9606.ENSP00000345152.

Structurei

3D structure databases

ProteinModelPortaliA0PK00.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 7777 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the TMEM120 family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329433.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiA0PK00.
OMAiHKECKEW.
OrthoDBiEOG790G18.
PhylomeDBiA0PK00.
TreeFamiTF313552.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PK00-1 [UniParc]FASTAAdd to Basket

« Hide

MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ    50
KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK 100
NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV 150
LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS 200
GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER 250
NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE 300
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP 339
Length:339
Mass (Da):40,246
Last modified:January 9, 2007 - v1
Checksum:i15A08B563ED261D3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921D → N in AAI27770. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK126568 mRNA. Translation: BAG54345.1.
BC127768 mRNA. Translation: AAI27769.1.
BC127769 mRNA. Translation: AAI27770.1.
CCDSiCCDS41852.1.
RefSeqiNP_001074294.2. NM_001080825.2.
UniGeneiHs.644504.

Genome annotation databases

EnsembliENST00000342607; ENSP00000345152; ENSG00000188735.
ENST00000449592; ENSP00000404991; ENSG00000188735.
GeneIDi144404.
KEGGihsa:144404.
UCSCiuc001ubc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK126568 mRNA. Translation: BAG54345.1 .
BC127768 mRNA. Translation: AAI27769.1 .
BC127769 mRNA. Translation: AAI27770.1 .
CCDSi CCDS41852.1.
RefSeqi NP_001074294.2. NM_001080825.2.
UniGenei Hs.644504.

3D structure databases

ProteinModelPortali A0PK00.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126849. 1 interaction.
STRINGi 9606.ENSP00000345152.

PTM databases

PhosphoSitei A0PK00.

Proteomic databases

MaxQBi A0PK00.
PaxDbi A0PK00.
PRIDEi A0PK00.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342607 ; ENSP00000345152 ; ENSG00000188735 .
ENST00000449592 ; ENSP00000404991 ; ENSG00000188735 .
GeneIDi 144404.
KEGGi hsa:144404.
UCSCi uc001ubc.4. human.

Organism-specific databases

CTDi 144404.
GeneCardsi GC12P122150.
HGNCi HGNC:32008. TMEM120B.
HPAi HPA014066.
neXtProti NX_A0PK00.
PharmGKBi PA162405862.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329433.
HOGENOMi HOG000267032.
HOVERGENi HBG108532.
InParanoidi A0PK00.
OMAi HKECKEW.
OrthoDBi EOG790G18.
PhylomeDBi A0PK00.
TreeFami TF313552.

Miscellaneous databases

ChiTaRSi TMEM120B. human.
GenomeRNAii 144404.
NextBioi 84906.
PROi A0PK00.

Gene expression databases

ArrayExpressi A0PK00.
Bgeei A0PK00.
Genevestigatori A0PK00.

Family and domain databases

InterProi IPR012926. TMPIT.
[Graphical view ]
PANTHERi PTHR21433. PTHR21433. 1 hit.
Pfami PF07851. TMPIT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiT120B_HUMAN
AccessioniPrimary (citable) accession number: A0PK00
Secondary accession number(s): A0PK01, B3KX33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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