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Protein

Transmembrane protein 120B

Gene

TMEM120B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for efficient adipogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32587-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:32008. TMEM120B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 124HelicalSequence analysisAdd BLAST23
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi144404.
OpenTargetsiENSG00000188735.
PharmGKBiPA162405862.

Polymorphism and mutation databases

BioMutaiTMEM120B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095291 – 339Transmembrane protein 120BAdd BLAST339

Proteomic databases

MaxQBiA0PK00.
PaxDbiA0PK00.
PRIDEiA0PK00.

PTM databases

iPTMnetiA0PK00.
PhosphoSitePlusiA0PK00.
SwissPalmiA0PK00.

Expressioni

Gene expression databases

BgeeiENSG00000188735.
ExpressionAtlasiA0PK00. baseline and differential.
GenevisibleiA0PK00. HS.

Organism-specific databases

HPAiHPA014066.

Interactioni

Subunit structurei

Heterooligomer with TMEM120A.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10171534,EBI-748961

Protein-protein interaction databases

BioGridi126849. 15 interactors.
IntActiA0PK00. 5 interactors.
STRINGi9606.ENSP00000345152.

Structurei

3D structure databases

ProteinModelPortaliA0PK00.
SMRiA0PK00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 77Sequence analysisAdd BLAST77

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiA0PK00.
OMAiRHKECKE.
OrthoDBiEOG091G0BVA.
PhylomeDBiA0PK00.
TreeFamiTF313552.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PK00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQLERCER EWHELEGEFQ ELQETHRIYK QKLEELAALQ TLCSSSISKQ
60 70 80 90 100
KKHLKDLKLT LQRCKRHASR EEAELVQQMA ANIKERQDVF FDMEAYLPKK
110 120 130 140 150
NGLYLNLVLG NVNVTLLSNQ AKFAYKDEYE KFKLYLTIIL LLGAVACRFV
160 170 180 190 200
LHYRVTDEVF NFLLVWYYCT LTIRESILIS NGSRIKGWWV SHHYVSTFLS
210 220 230 240 250
GVMLTWPNGP IYQKFRNQFL AFSIFQSCVQ FLQYYYQRGC LYRLRALGER
260 270 280 290 300
NHLDLTVEGF QSWMWRGLTF LLPFLFCGHF WQLYNAVTLF ELSSHEECRE
310 320 330
WQVFVLAFTF LILFLGNFLT TLKVVHAKLQ KNRGKTKQP
Length:339
Mass (Da):40,246
Last modified:January 9, 2007 - v1
Checksum:i15A08B563ED261D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92D → N in AAI27770 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126568 mRNA. Translation: BAG54345.1.
BC127768 mRNA. Translation: AAI27769.1.
BC127769 mRNA. Translation: AAI27770.1.
CCDSiCCDS41852.1.
RefSeqiNP_001074294.2. NM_001080825.2.
XP_016874342.1. XM_017018853.1.
UniGeneiHs.644504.
Hs.744740.

Genome annotation databases

EnsembliENST00000342607; ENSP00000345152; ENSG00000188735.
ENST00000449592; ENSP00000404991; ENSG00000188735.
GeneIDi144404.
KEGGihsa:144404.
UCSCiuc001ubc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126568 mRNA. Translation: BAG54345.1.
BC127768 mRNA. Translation: AAI27769.1.
BC127769 mRNA. Translation: AAI27770.1.
CCDSiCCDS41852.1.
RefSeqiNP_001074294.2. NM_001080825.2.
XP_016874342.1. XM_017018853.1.
UniGeneiHs.644504.
Hs.744740.

3D structure databases

ProteinModelPortaliA0PK00.
SMRiA0PK00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126849. 15 interactors.
IntActiA0PK00. 5 interactors.
STRINGi9606.ENSP00000345152.

PTM databases

iPTMnetiA0PK00.
PhosphoSitePlusiA0PK00.
SwissPalmiA0PK00.

Polymorphism and mutation databases

BioMutaiTMEM120B.

Proteomic databases

MaxQBiA0PK00.
PaxDbiA0PK00.
PRIDEiA0PK00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342607; ENSP00000345152; ENSG00000188735.
ENST00000449592; ENSP00000404991; ENSG00000188735.
GeneIDi144404.
KEGGihsa:144404.
UCSCiuc001ubc.5. human.

Organism-specific databases

CTDi144404.
DisGeNETi144404.
GeneCardsiTMEM120B.
HGNCiHGNC:32008. TMEM120B.
HPAiHPA014066.
MIMi616551. gene.
neXtProtiNX_A0PK00.
OpenTargetsiENSG00000188735.
PharmGKBiPA162405862.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiA0PK00.
OMAiRHKECKE.
OrthoDBiEOG091G0BVA.
PhylomeDBiA0PK00.
TreeFamiTF313552.

Enzyme and pathway databases

BioCyciZFISH:G66-32587-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM120B. human.
GenomeRNAii144404.
PROiA0PK00.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188735.
ExpressionAtlasiA0PK00. baseline and differential.
GenevisibleiA0PK00. HS.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT120B_HUMAN
AccessioniPrimary (citable) accession number: A0PK00
Secondary accession number(s): A0PK01, B3KX33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.