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Protein

Glucoside xylosyltransferase 2

Gene

GXYLT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.1 Publication

Catalytic activityi

UDP-alpha-D-xylose + beta-D-glucosyl-R = UDP + alpha-D-xylose-(1->3)-beta-D-glucosyl-R.

GO - Molecular functioni

  • UDP-xylosyltransferase activity Source: UniProtKB

GO - Biological processi

  • O-glycan processing Source: UniProtKB

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

SIGNORiA0PJZ3

Protein family/group databases

CAZyiGT8 Glycosyltransferase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Glucoside xylosyltransferase 2 (EC:2.4.2.n2)
Alternative name(s):
Glycosyltransferase 8 domain-containing protein 4
Gene namesi
Name:GXYLT2
Synonyms:GLT8D4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172986.12
HGNCiHGNC:33383 GXYLT2
MIMi613322 gene
neXtProtiNX_A0PJZ3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini26 – 443LumenalSequence analysisAdd BLAST418

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172986
PharmGKBiPA165697418

Polymorphism and mutation databases

BioMutaiGXYLT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885391 – 443Glucoside xylosyltransferase 2Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA0PJZ3
PaxDbiA0PJZ3
PRIDEiA0PJZ3

PTM databases

iPTMnetiA0PJZ3
PhosphoSitePlusiA0PJZ3

Expressioni

Gene expression databases

BgeeiENSG00000172986
CleanExiHS_GLT8D4
ExpressionAtlasiA0PJZ3 baseline and differential
GenevisibleiA0PJZ3 HS

Organism-specific databases

HPAiHPA068429

Interactioni

Protein-protein interaction databases

BioGridi608376, 12 interactors
STRINGi9606.ENSP00000374268

Structurei

3D structure databases

ProteinModelPortaliA0PJZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 98Arg-richAdd BLAST31

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3765 Eukaryota
ENOG410XRNY LUCA
GeneTreeiENSGT00510000046589
HOGENOMiHOG000264229
HOVERGENiHBG059879
InParanoidiA0PJZ3
KOiK13676
OMAiWKLLRQF
OrthoDBiEOG091G07SJ
PhylomeDBiA0PJZ3
TreeFamiTF323210

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495 Glyco_trans_8
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01501 Glyco_transf_8, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

A0PJZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRSKAAAL LLLALAALLL ALLSLRAGRA EPPALPARPA SAPQRHPAPV
60 70 80 90 100
PARWPGPGAL PGASPGVRRR RPPRPRPRAG RRGAARLEKL ARRPGEPRSF
110 120 130 140 150
QAVLPPELWI HLAVVACGNR LEETLVMLKS AVLFSHRKIQ FHIFTEDSLK
160 170 180 190 200
PEFDKQLRQW PDSYTKKFEH RIYPITFSVG NPQEWKKLFK PCAAQRLFLP
210 220 230 240 250
VILKDVDSLL YVDTDVLFLR PVDDIWKLLR LFNSTQLAAM APEHEIPKIG
260 270 280 290 300
WYSRFARHPF YGSAGVNSGV MLMNLTRIRS TQFKNSMIPT GLAWEDMLYP
310 320 330 340 350
LYQKYKNAIT WGDQDLLNII FYFNPECLYV FPCQWNYRPD HCMYGSNCRE
360 370 380 390 400
AEHEGVSVLH GNRGVYHDDK QPTFRALYEA IRDFPFQDNL FQSMYYPLQL
410 420 430 440
KFLETVHTLC GRIPQVFLKQ IEKTMKRAYE KHVIIHVGPN QMH
Length:443
Mass (Da):51,056
Last modified:May 29, 2007 - v2
Checksum:iA53878D061AA27D9
GO

Sequence cautioni

The sequence AAI27734 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC098481 Genomic DNA No translation available.
AC114876 Genomic DNA No translation available.
BC127733 mRNA Translation: AAI27734.1 Different initiation.
CCDSiCCDS46870.1
RefSeqiNP_001073862.1, NM_001080393.1
XP_011532370.1, XM_011534068.1
UniGeneiHs.710275

Genome annotation databases

EnsembliENST00000389617; ENSP00000374268; ENSG00000172986
GeneIDi727936
KEGGihsa:727936
UCSCiuc003dpg.4 human

Similar proteinsi

Entry informationi

Entry nameiGXLT2_HUMAN
AccessioniPrimary (citable) accession number: A0PJZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: March 28, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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