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A0PJY2

- FEZF1_HUMAN

UniProt

A0PJY2 - FEZF1_HUMAN

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Protein

Fez family zinc finger protein 1

Gene

FEZF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri260 – 28223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42324C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. forebrain anterior/posterior pattern specification Source: Ensembl
  3. negative regulation of cell proliferation Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. neuron migration Source: Ensembl
  6. olfactory bulb development Source: Ensembl
  7. positive regulation of neuron differentiation Source: Ensembl
  8. positive regulation of transcription, DNA-templated Source: Ensembl
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 1
Alternative name(s):
Zinc finger protein 312B
Gene namesi
Name:FEZF1
Synonyms:FEZ, ZNF312B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:22788. FEZF1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388419.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Fez family zinc finger protein 1PRO_0000295114Add
BLAST

Proteomic databases

PaxDbiA0PJY2.
PRIDEiA0PJY2.

PTM databases

PhosphoSiteiA0PJY2.

Expressioni

Tissue specificityi

Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2-to 20-fold increase is found in over 50% of gastric cancer tissues.1 Publication

Gene expression databases

BgeeiA0PJY2.
CleanExiHS_FEZF1.
ExpressionAtlasiA0PJY2. baseline.
GenevestigatoriA0PJY2.

Interactioni

Protein-protein interaction databases

BioGridi133180. 2 interactions.
STRINGi9606.ENSP00000332777.

Structurei

3D structure databases

ProteinModelPortaliA0PJY2.
SMRiA0PJY2. Positions 258-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi28 – 4316Engrailed homology 1 repressorBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi433 – 46836Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri260 – 28223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42324C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiA0PJY2.
OMAiVPAVEKY.
OrthoDBiEOG7Z0JW5.
PhylomeDBiA0PJY2.
TreeFamiTF316780.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A0PJY2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH
60 70 80 90 100
FLQGALPKGE PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL
110 120 130 140 150
EAPAAPAAVP SAPAFSCSDL LNCALSLKGD LARDALPLQQ YKLVRPRVVN
160 170 180 190 200
HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP VASYFLSSPL HPQPKTYLAE
210 220 230 240 250
RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK IAFKTSDFSR
260 270 280 290 300
GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA
310 320 330 340 350
STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG
360 370 380 390 400
KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF
410 420 430 440 450
TCPTCGKGFC RNFDLKKHVR KLHDSSLGLA RTPAGEPGTE PPPPLPQQPP
460 470
MTLPPLQPPL PTPGPLQPGL HQGHQ
Length:475
Mass (Da):52,038
Last modified:January 9, 2007 - v1
Checksum:iA26945A0C4E9316A
GO
Isoform 2 (identifier: A0PJY2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-193: Missing.

Note: No experimental confirmation available.

Show »
Length:425
Mass (Da):46,677
Checksum:iBD12C0C98DB12E2A
GO
Isoform 3 (identifier: A0PJY2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.

Note: Gene prediction based on EST data.

Show »
Length:471
Mass (Da):51,651
Checksum:iFD6569909179F243
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 19350Missing in isoform 2. 1 PublicationVSP_026732Add
BLAST
Alternative sequencei265 – 2684Missing in isoform 3. CuratedVSP_026733

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300742 mRNA. Translation: BAG62411.1.
CH236947 Genomic DNA. Translation: EAL24342.1.
BC127714 mRNA. Translation: AAI27715.1.
BC127715 mRNA. Translation: AAI27716.1.
BC136684 mRNA. Translation: AAI36685.1.
BC144367 mRNA. Translation: AAI44368.1.
CCDSiCCDS34741.2. [A0PJY2-1]
CCDS55157.1. [A0PJY2-2]
RefSeqiNP_001019784.2. NM_001024613.2. [A0PJY2-1]
NP_001153736.1. NM_001160264.1. [A0PJY2-2]
XP_005250394.1. XM_005250337.1. [A0PJY2-1]
UniGeneiHs.553970.

Genome annotation databases

EnsembliENST00000427185; ENSP00000392727; ENSG00000128610. [A0PJY2-2]
ENST00000442488; ENSP00000411145; ENSG00000128610. [A0PJY2-1]
GeneIDi389549.
KEGGihsa:389549.
UCSCiuc003vkc.3. human. [A0PJY2-2]
uc003vkd.3. human. [A0PJY2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300742 mRNA. Translation: BAG62411.1 .
CH236947 Genomic DNA. Translation: EAL24342.1 .
BC127714 mRNA. Translation: AAI27715.1 .
BC127715 mRNA. Translation: AAI27716.1 .
BC136684 mRNA. Translation: AAI36685.1 .
BC144367 mRNA. Translation: AAI44368.1 .
CCDSi CCDS34741.2. [A0PJY2-1 ]
CCDS55157.1. [A0PJY2-2 ]
RefSeqi NP_001019784.2. NM_001024613.2. [A0PJY2-1 ]
NP_001153736.1. NM_001160264.1. [A0PJY2-2 ]
XP_005250394.1. XM_005250337.1. [A0PJY2-1 ]
UniGenei Hs.553970.

3D structure databases

ProteinModelPortali A0PJY2.
SMRi A0PJY2. Positions 258-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 133180. 2 interactions.
STRINGi 9606.ENSP00000332777.

PTM databases

PhosphoSitei A0PJY2.

Proteomic databases

PaxDbi A0PJY2.
PRIDEi A0PJY2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000427185 ; ENSP00000392727 ; ENSG00000128610 . [A0PJY2-2 ]
ENST00000442488 ; ENSP00000411145 ; ENSG00000128610 . [A0PJY2-1 ]
GeneIDi 389549.
KEGGi hsa:389549.
UCSCi uc003vkc.3. human. [A0PJY2-2 ]
uc003vkd.3. human. [A0PJY2-1 ]

Organism-specific databases

CTDi 389549.
GeneCardsi GC07M121941.
HGNCi HGNC:22788. FEZF1.
MIMi 613301. gene.
neXtProti NX_A0PJY2.
PharmGKBi PA162388419.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00740000115096.
HOGENOMi HOG000013052.
HOVERGENi HBG098441.
InParanoidi A0PJY2.
OMAi VPAVEKY.
OrthoDBi EOG7Z0JW5.
PhylomeDBi A0PJY2.
TreeFami TF316780.

Miscellaneous databases

GenomeRNAii 389549.
NextBioi 102929.
PROi A0PJY2.
SOURCEi Search...

Gene expression databases

Bgeei A0PJY2.
CleanExi HS_FEZF1.
ExpressionAtlasi A0PJY2. baseline.
Genevestigatori A0PJY2.

Family and domain databases

Gene3Di 3.30.160.60. 6 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  4. "Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene."
    Song I.S., Oh N.S., Kim H.T., Ha G.H., Jeong S.Y., Kim J.M., Kim D.I., Yoo H.S., Kim C.H., Kim N.S.
    Cancer Res. 69:3131-3139(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiFEZF1_HUMAN
AccessioniPrimary (citable) accession number: A0PJY2
Secondary accession number(s): A0PJY3
, A4D0W3, B4DUP9, B7ZM98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Triggers oncogenic activity specifically in gastric tumors through activation of KRAS in the ERK signaling pathway.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3