A0PJY2 (FEZF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fez family zinc finger protein 1

Alternative name(s):
Zinc finger protein 312B

Gene names

Name:	FEZF1
Synonyms:	FEZ, ZNF312B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors By similarity.
Subcellular location	Nucleus Ref.4.
Tissue specificity	Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2-to 20-fold increase is found in over 50% of gastric cancer tissues. Ref.4
Miscellaneous	Triggers oncogenic activity specifically in gastric tumors through activation of KRAS in the ERK signaling pathway.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from electronic annotation. Source: Compara forebrain anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara olfactory bulb development Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A0PJY2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A0PJY2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     144-193: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: A0PJY2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     265-268: Missing.

Note: Gene prediction based on EST data.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Fez family zinc finger protein 1		PRO_0000295114
Regions
	Zinc finger	260 – 282	23	C2H2-type 1
	Zinc finger	288 – 310	23	C2H2-type 2
	Zinc finger	316 – 338	23	C2H2-type 3
	Zinc finger	344 – 366	23	C2H2-type 4
	Zinc finger	372 – 394	23	C2H2-type 5
	Zinc finger	400 – 423	24	C2H2-type 6
	Motif	28 – 43	16	Engrailed homology 1 repressor By similarity
	Compositional bias	433 – 468	36	Pro-rich
Natural variations
	Alternative sequence	144 – 193	50	Missing in isoform 2.		VSP_026732
	Alternative sequence	265 – 268	4	Missing in isoform 3.		VSP_026733

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: A26945A0C4E9316A	FASTA	475	52,038
	10 20 30 40 50 60 MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH FLQGALPKGE 70 80 90 100 110 120 PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL EAPAAPAAVP SAPAFSCSDL 130 140 150 160 170 180 LNCALSLKGD LARDALPLQQ YKLVRPRVVN HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP 190 200 210 220 230 240 VASYFLSSPL HPQPKTYLAE RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK 250 260 270 280 290 300 IAFKTSDFSR GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC KVCGKGFRQA 310 320 330 340 350 360 STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG KGFHQKGNYK 370 380 390 400 410 420 NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF TCPTCGKGFC RNFDLKKHVR 430 440 450 460 470 KLHDSSLGLA RTPAGEPGTE PPPPLPQQPP MTLPPLQPPL PTPGPLQPGL HQGHQ
	Isoform 2 [UniParc]. Checksum: BD12C0C98DB12E2A	FASTA	425	46,677
	10 20 30 40 50 60 MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH FLQGALPKGE 70 80 90 100 110 120 PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL EAPAAPAAVP SAPAFSCSDL 130 140 150 160 170 180 LNCALSLKGD LARDALPLQQ YKLPKTYLAE RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM 190 200 210 220 230 240 KESAQLLSEK IAFKTSDFSR GSPNAKPKVF TCEVCGKVFN AHYNLTRHMP VHTGARPFVC 250 260 270 280 290 300 KVCGKGFRQA STLCRHKIIH TQEKPHKCNQ CGKAFNRSST LNTHTRIHAG YKPFVCEFCG 310 320 330 340 350 360 KGFHQKGNYK NHKLTHSGEK QFKCNICNKA FHQVYNLTFH MHTHNDKKPF TCPTCGKGFC 370 380 390 400 410 420 RNFDLKKHVR KLHDSSLGLA RTPAGEPGTE PPPPLPQQPP MTLPPLQPPL PTPGPLQPGL HQGHQ
	Isoform 3 [UniParc]. Checksum: FD6569909179F243	FASTA	471	51,651
	10 20 30 40 50 60 MDSSCHNATT KMLATAPARG NMMSTSKPLA FSIERIMART PEPKALPVPH FLQGALPKGE 70 80 90 100 110 120 PKHSLHLNSS IPCMIPFVPV AYDTSPKAGV TGSEPRKASL EAPAAPAAVP SAPAFSCSDL 130 140 150 160 170 180 LNCALSLKGD LARDALPLQQ YKLVRPRVVN HSSFHAMGAL CYLNRGDGPC HPAAGVNIHP 190 200 210 220 230 240 VASYFLSSPL HPQPKTYLAE RNKLVVPAVE KYPSGVAFKD LSQAQLQHYM KESAQLLSEK 250 260 270 280 290 300 IAFKTSDFSR GSPNAKPKVF TCEVFNAHYN LTRHMPVHTG ARPFVCKVCG KGFRQASTLC 310 320 330 340 350 360 RHKIIHTQEK PHKCNQCGKA FNRSSTLNTH TRIHAGYKPF VCEFCGKGFH QKGNYKNHKL 370 380 390 400 410 420 THSGEKQFKC NICNKAFHQV YNLTFHMHTH NDKKPFTCPT CGKGFCRNFD LKKHVRKLHD 430 440 450 460 470 SSLGLARTPA GEPGTEPPPP LPQQPPMTLP PLQPPLPTPG PLQPGLHQGH Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Testis.
[4]	"Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene." Song I.S., Oh N.S., Kim H.T., Ha G.H., Jeong S.Y., Kim J.M., Kim D.I., Yoo H.S., Kim C.H., Kim N.S. Cancer Res. 69:3131-3139(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK300742 mRNA. Translation: BAG62411.1. CH236947 Genomic DNA. Translation: EAL24342.1. BC127714 mRNA. Translation: AAI27715.1. BC127715 mRNA. Translation: AAI27716.1. BC136684 mRNA. Translation: AAI36685.1. BC144367 mRNA. Translation: AAI44368.1.
IPI	IPI00376675. IPI00816263. IPI00852828.
RefSeq	NP_001019784.2. NM_001024613.2. NP_001153736.1. NM_001160264.1.
UniGene	Hs.553970.
3D structure databases
ProteinModelPortal	A0PJY2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000332777.
PTM databases
PhosphoSite	A0PJY2.
Proteomic databases
PaxDb	A0PJY2.
PRIDE	A0PJY2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331178; ENSP00000332777; ENSG00000128610. ENST00000427185; ENSP00000392727; ENSG00000128610. ENST00000442488; ENSP00000411145; ENSG00000128610.
GeneID	389549.
KEGG	hsa:389549.
UCSC	uc003vkc.3. human. uc003vkd.3. human.
Organism-specific databases
CTD	389549.
GeneCards	GC07M121941.
HGNC	HGNC:22788. FEZF1.
MIM	613301. gene.
neXtProt	NX_A0PJY2.
PharmGKB	PA162388419.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000013052.
HOVERGEN	HBG098441.
InParanoid	A0PJY2.
OMA	RGSPNAK.
OrthoDB	EOG4G4GQB.
Gene expression databases
ArrayExpress	A0PJY2.
Bgee	A0PJY2.
CleanEx	HS_FEZF1.
Genevestigator	A0PJY2.
Family and domain databases
Gene3D	3.30.160.60. 6 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 6 hits. PS50157. ZINC_FINGER_C2H2_2. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	389549.
NextBio	102929.
SOURCE	Search...

Entry information

Entry name

FEZF1_HUMAN

Accession

Primary (citable) accession number: A0PJY2
Secondary accession number(s): A0PJY3 , A4D0W3, B4DUP9, B7ZM98

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.