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Protein

Transmembrane protein 82

Gene

TMEM82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 82
Gene namesi
Name:TMEM82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32350. TMEM82.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei145 – 167HelicalSequence analysisAdd BLAST23
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei233 – 252HelicalSequence analysisAdd BLAST20
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi388595.
OpenTargetsiENSG00000162460.
PharmGKBiPA162406636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092361 – 343Transmembrane protein 82Add BLAST343

Proteomic databases

PaxDbiA0PJX8.
PRIDEiA0PJX8.

PTM databases

PhosphoSitePlusiA0PJX8.

Expressioni

Gene expression databases

BgeeiENSG00000162460.
CleanExiHS_TMEM82.

Organism-specific databases

HPAiHPA060282.

Structurei

3D structure databases

ProteinModelPortaliA0PJX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 302Leu-richAdd BLAST299

Sequence similaritiesi

Belongs to the TMEM82 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHBQ. Eukaryota.
ENOG4111FKU. LUCA.
GeneTreeiENSGT00500000045021.
HOGENOMiHOG000154651.
HOVERGENiHBG108589.
InParanoidiA0PJX8.
OMAiFVGCAND.
OrthoDBiEOG091G0GW7.
PhylomeDBiA0PJX8.
TreeFamiTF332112.

Family and domain databases

InterProiIPR031648. TMEM82.
[Graphical view]
PfamiPF15816. TMEM82. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PJX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSLPSLPSW LPGLPSLEWG SSLLDSLLQG LIGALGVLVL NSLLKVYFFV
60 70 80 90 100
GCANDPQRRP EKERLRAQWA SLETVHLAGL ALFLTVVGSR VAALVVLEFS
110 120 130 140 150
LRAVSTLLSL GKGSQGAAER LQLYLLCQYS LGCGLTCGLS FLQEGAPHRT
160 170 180 190 200
LNLLLSLGLA TLLGLGARRL HRHVCRLYEL HSSQRYCGVC LGLLAHAHGL
210 220 230 240 250
PQLLGRALAI AFAVGDLAAV ALINQDFLTT SEAMRFWTPL TICYTLLVIY
260 270 280 290 300
MQEEQRQHPG LQSQVQTVLV RMGGLFVLLL TVGRWLDLLG ILVSLLGELW
310 320 330 340
CLVGVRTLLD LCQIQDFPSQ RPPVSTPSQP LPSAPQSQSS APS
Length:343
Mass (Da):37,222
Last modified:March 3, 2009 - v2
Checksum:i1A3B2FE31D0394EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308L → IW in AAI27708 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036917284R → H.Corresponds to variant rs11580250dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450998 Genomic DNA. Translation: CAH70850.1.
BC127706 mRNA. Translation: AAI27707.1.
BC127707 mRNA. Translation: AAI27708.1.
BC137239 mRNA. Translation: AAI37240.1.
BC137240 mRNA. Translation: AAI37241.1.
CCDSiCCDS30608.1.
RefSeqiNP_001013663.1. NM_001013641.2.
UniGeneiHs.454828.

Genome annotation databases

EnsembliENST00000375782; ENSP00000364938; ENSG00000162460.
GeneIDi388595.
KEGGihsa:388595.
UCSCiuc001axc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450998 Genomic DNA. Translation: CAH70850.1.
BC127706 mRNA. Translation: AAI27707.1.
BC127707 mRNA. Translation: AAI27708.1.
BC137239 mRNA. Translation: AAI37240.1.
BC137240 mRNA. Translation: AAI37241.1.
CCDSiCCDS30608.1.
RefSeqiNP_001013663.1. NM_001013641.2.
UniGeneiHs.454828.

3D structure databases

ProteinModelPortaliA0PJX8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiA0PJX8.

Proteomic databases

PaxDbiA0PJX8.
PRIDEiA0PJX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375782; ENSP00000364938; ENSG00000162460.
GeneIDi388595.
KEGGihsa:388595.
UCSCiuc001axc.5. human.

Organism-specific databases

CTDi388595.
DisGeNETi388595.
GeneCardsiTMEM82.
HGNCiHGNC:32350. TMEM82.
HPAiHPA060282.
neXtProtiNX_A0PJX8.
OpenTargetsiENSG00000162460.
PharmGKBiPA162406636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBQ. Eukaryota.
ENOG4111FKU. LUCA.
GeneTreeiENSGT00500000045021.
HOGENOMiHOG000154651.
HOVERGENiHBG108589.
InParanoidiA0PJX8.
OMAiFVGCAND.
OrthoDBiEOG091G0GW7.
PhylomeDBiA0PJX8.
TreeFamiTF332112.

Miscellaneous databases

GenomeRNAii388595.
PROiA0PJX8.

Gene expression databases

BgeeiENSG00000162460.
CleanExiHS_TMEM82.

Family and domain databases

InterProiIPR031648. TMEM82.
[Graphical view]
PfamiPF15816. TMEM82. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM82_HUMAN
AccessioniPrimary (citable) accession number: A0PJX8
Secondary accession number(s): B2RP27, Q5VVD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.