A0PJX8 (TMM82_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 82

Gene names

Name:

TMEM82

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM82 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Transmembrane protein 82		PRO_0000309236
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	77 – 97	21	Helical; Potential
	Transmembrane	121 – 141	21	Helical; Potential
	Transmembrane	145 – 167	23	Helical; Potential
	Transmembrane	203 – 223	21	Helical; Potential
	Transmembrane	233 – 252	20	Helical; Potential
	Transmembrane	263 – 283	21	Helical; Potential
	Transmembrane	285 – 305	21	Helical; Potential
	Compositional bias	4 – 302	299	Leu-rich
Natural variations
	Natural variant	284	1	R → H. Corresponds to variant rs11580250 [ dbSNP | Ensembl ].		VAR_036917
Experimental info
	Sequence conflict	308	1	L → IW in AAI27708. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	A0PJX8 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: 1A3B2FE31D0394EC	FASTA	343	37,222
	10 20 30 40 50 60 MFSLPSLPSW LPGLPSLEWG SSLLDSLLQG LIGALGVLVL NSLLKVYFFV GCANDPQRRP 70 80 90 100 110 120 EKERLRAQWA SLETVHLAGL ALFLTVVGSR VAALVVLEFS LRAVSTLLSL GKGSQGAAER 130 140 150 160 170 180 LQLYLLCQYS LGCGLTCGLS FLQEGAPHRT LNLLLSLGLA TLLGLGARRL HRHVCRLYEL 190 200 210 220 230 240 HSSQRYCGVC LGLLAHAHGL PQLLGRALAI AFAVGDLAAV ALINQDFLTT SEAMRFWTPL 250 260 270 280 290 300 TICYTLLVIY MQEEQRQHPG LQSQVQTVLV RMGGLFVLLL TVGRWLDLLG ILVSLLGELW 310 320 330 340 CLVGVRTLLD LCQIQDFPSQ RPPVSTPSQP LPSAPQSQSS APS

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL450998 Genomic DNA. Translation: CAH70850.1. BC127706 mRNA. Translation: AAI27707.1. BC127707 mRNA. Translation: AAI27708.1. BC137239 mRNA. Translation: AAI37240.1. BC137240 mRNA. Translation: AAI37241.1.
IPI	IPI00174997.
RefSeq	NP_001013663.1. NM_001013641.2.
UniGene	Hs.454828.
3D structure databases
ProteinModelPortal	A0PJX8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000364938.
Proteomic databases
PaxDb	A0PJX8.
PRIDE	A0PJX8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375782; ENSP00000364938; ENSG00000162460.
GeneID	388595.
KEGG	hsa:388595.
UCSC	uc001axc.3. human.
Organism-specific databases
CTD	388595.
GeneCards	GC01P016068.
HGNC	HGNC:32350. TMEM82.
neXtProt	NX_A0PJX8.
PharmGKB	PA162406636.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25579.
HOGENOM	HOG000154651.
HOVERGEN	HBG108589.
InParanoid	A0PJX8.
OMA	CQIQDFP.
OrthoDB	EOG4C2HB8.
Gene expression databases
Bgee	A0PJX8.
CleanEx	HS_TMEM82.
Genevestigator	A0PJX8.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	388595.
NextBio	102207.

Entry information

Entry name

TMM82_HUMAN

Accession

Primary (citable) accession number: A0PJX8
Secondary accession number(s): B2RP27, Q5VVD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	March 3, 2009
Last modified:	April 3, 2013
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.