A0PJX4 (SHSA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein shisa-3 homolog

Gene names

Name:

SHISA3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the shisa family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 238	217	Protein shisa-3 homolog		PRO_0000330025
Regions
	Topological domain	22 – 98	77	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Topological domain	120 – 238	119	Cytoplasmic Potential
	Compositional bias	190 – 195	6	Poly-Pro
Natural variations
	Natural variant	13	1	W → C. Ref.2 Corresponds to variant rs11733156 [ dbSNP | Ensembl ].		VAR_042687
Experimental info
	Sequence conflict	95	1	V → G in AAH12029. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	A0PJX4 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 8469E3758F61D22C	FASTA	238	25,832
	10 20 30 40 50 60 MRALLALCLL LGWLRWGPAG AQQSGEYCHG WVDVQGNYHE GFQCPEDFDT LDATICCGSC 70 80 90 100 110 120 ALRYCCAAAD ARLEQGGCTN DRRELEHPGI TAQPVYVPFL IVGSIFIAFI ILGSVVAIYC 130 140 150 160 170 180 CTCLRPKEPS QQPIRFSLRS YQTETLPMIL TSTSPRAPSR QSSTATSSSS TGGSIRRFSF 190 200 210 220 230 ARAEPGCLVP SPPPPYTTSH SIHLAQPSGF LVSPQYFAYP LQQEPPLPGK SCPDFSSS

References

[1]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-13. Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471069 Genomic DNA. Translation: EAW93002.1. BC012029 mRNA. Translation: AAH12029.1. BC127690 mRNA. Translation: AAI27691.1. BC127691 mRNA. Translation: AAI27692.1.
IPI	IPI00455600.
RefSeq	NP_001073974.1. NM_001080505.1.
UniGene	Hs.370904.
3D structure databases
ProteinModelPortal	A0PJX4.
ModBase	Search...
PTM databases
PhosphoSite	A0PJX4.
Proteomic databases
PaxDb	A0PJX4.
PRIDE	A0PJX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000319234; ENSP00000326445; ENSG00000178343.
GeneID	152573.
KEGG	hsa:152573.
UCSC	uc003gwp.3. human.
Organism-specific databases
CTD	152573.
GeneCards	GC04P042399.
HGNC	HGNC:25159. SHISA3.
HPA	HPA054754.
neXtProt	NX_A0PJX4.
PharmGKB	PA162403293.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40940.
HOGENOM	HOG000234350.
HOVERGEN	HBG059385.
InParanoid	A0PJX4.
OMA	AQPVYVP.
OrthoDB	EOG4RXZ13.
Gene expression databases
Bgee	A0PJX4.
CleanEx	HS_SHISA3.
Genevestigator	A0PJX4.
Family and domain databases
InterPro	IPR026910. Shisa. [Graphical view]
Pfam	PF13908. Shisa. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	152573.
NextBio	86980.

Entry information

Entry name

SHSA3_HUMAN

Accession

Primary (citable) accession number: A0PJX4
Secondary accession number(s): A0PJX3, Q96EQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	January 9, 2007
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.