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Protein

Protein shisa-3 homolog

Gene

SHISA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-3 homolog
Gene namesi
Name:SHISA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25159. SHISA3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 98LumenalCuratedAdd BLAST77
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 238CytoplasmicCuratedAdd BLAST119

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi152573.
OpenTargetsiENSG00000178343.
PharmGKBiPA162403293.

Polymorphism and mutation databases

BioMutaiSHISA3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000033002522 – 238Protein shisa-3 homologAdd BLAST217

Proteomic databases

PaxDbiA0PJX4.
PRIDEiA0PJX4.

PTM databases

iPTMnetiA0PJX4.
PhosphoSitePlusiA0PJX4.

Expressioni

Gene expression databases

BgeeiENSG00000178343.
CleanExiHS_SHISA3.
GenevisibleiA0PJX4. HS.

Organism-specific databases

HPAiHPA054754.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PNMA1Q8ND903EBI-10171518,EBI-302345

Protein-protein interaction databases

BioGridi127452. 1 interactor.
IntActiA0PJX4. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliA0PJX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi190 – 195Poly-Pro6

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF26. Eukaryota.
ENOG4111FHU. LUCA.
GeneTreeiENSGT00390000016402.
HOGENOMiHOG000234350.
HOVERGENiHBG059385.
InParanoidiA0PJX4.
OMAiCTNDREV.
OrthoDBiEOG091G0TZW.
PhylomeDBiA0PJX4.
TreeFamiTF330800.

Family and domain databases

InterProiIPR026910. Shisa.
[Graphical view]
PfamiPF13908. Shisa. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A0PJX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALLALCLL LGWLRWGPAG AQQSGEYCHG WVDVQGNYHE GFQCPEDFDT
60 70 80 90 100
LDATICCGSC ALRYCCAAAD ARLEQGGCTN DRRELEHPGI TAQPVYVPFL
110 120 130 140 150
IVGSIFIAFI ILGSVVAIYC CTCLRPKEPS QQPIRFSLRS YQTETLPMIL
160 170 180 190 200
TSTSPRAPSR QSSTATSSSS TGGSIRRFSF ARAEPGCLVP SPPPPYTTSH
210 220 230
SIHLAQPSGF LVSPQYFAYP LQQEPPLPGK SCPDFSSS
Length:238
Mass (Da):25,832
Last modified:January 9, 2007 - v1
Checksum:i8469E3758F61D22C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95V → G in AAH12029 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04268713W → C.1 PublicationCorresponds to variant rs11733156dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471069 Genomic DNA. Translation: EAW93002.1.
BC012029 mRNA. Translation: AAH12029.1.
BC127690 mRNA. Translation: AAI27691.1.
BC127691 mRNA. Translation: AAI27692.1.
CCDSiCCDS33979.1.
RefSeqiNP_001073974.1. NM_001080505.1.
UniGeneiHs.370904.

Genome annotation databases

EnsembliENST00000319234; ENSP00000326445; ENSG00000178343.
GeneIDi152573.
KEGGihsa:152573.
UCSCiuc003gwp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471069 Genomic DNA. Translation: EAW93002.1.
BC012029 mRNA. Translation: AAH12029.1.
BC127690 mRNA. Translation: AAI27691.1.
BC127691 mRNA. Translation: AAI27692.1.
CCDSiCCDS33979.1.
RefSeqiNP_001073974.1. NM_001080505.1.
UniGeneiHs.370904.

3D structure databases

ProteinModelPortaliA0PJX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127452. 1 interactor.
IntActiA0PJX4. 2 interactors.

PTM databases

iPTMnetiA0PJX4.
PhosphoSitePlusiA0PJX4.

Polymorphism and mutation databases

BioMutaiSHISA3.

Proteomic databases

PaxDbiA0PJX4.
PRIDEiA0PJX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319234; ENSP00000326445; ENSG00000178343.
GeneIDi152573.
KEGGihsa:152573.
UCSCiuc003gwp.3. human.

Organism-specific databases

CTDi152573.
DisGeNETi152573.
GeneCardsiSHISA3.
HGNCiHGNC:25159. SHISA3.
HPAiHPA054754.
neXtProtiNX_A0PJX4.
OpenTargetsiENSG00000178343.
PharmGKBiPA162403293.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF26. Eukaryota.
ENOG4111FHU. LUCA.
GeneTreeiENSGT00390000016402.
HOGENOMiHOG000234350.
HOVERGENiHBG059385.
InParanoidiA0PJX4.
OMAiCTNDREV.
OrthoDBiEOG091G0TZW.
PhylomeDBiA0PJX4.
TreeFamiTF330800.

Miscellaneous databases

GenomeRNAii152573.
PROiA0PJX4.

Gene expression databases

BgeeiENSG00000178343.
CleanExiHS_SHISA3.
GenevisibleiA0PJX4. HS.

Family and domain databases

InterProiIPR026910. Shisa.
[Graphical view]
PfamiPF13908. Shisa. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHSA3_HUMAN
AccessioniPrimary (citable) accession number: A0PJX4
Secondary accession number(s): A0PJX3, Q96EQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: November 30, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.