Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0PJX4 (SHSA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein shisa-3 homolog
Gene names
Name:SHISA3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the shisa family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 238217Protein shisa-3 homolog
PRO_0000330025

Regions

Topological domain22 – 9877Extracellular Potential
Transmembrane99 – 11921Helical; Potential
Topological domain120 – 238119Cytoplasmic Potential
Compositional bias190 – 1956Poly-Pro

Natural variations

Natural variant131W → C. Ref.2
Corresponds to variant rs11733156 [ dbSNP | Ensembl ].
VAR_042687

Experimental info

Sequence conflict951V → G in AAH12029. Ref.2

Sequences

Sequence LengthMass (Da)Tools
A0PJX4 [UniParc].

Last modified January 9, 2007. Version 1.
Checksum: 8469E3758F61D22C

FASTA23825,832
        10         20         30         40         50         60 
MRALLALCLL LGWLRWGPAG AQQSGEYCHG WVDVQGNYHE GFQCPEDFDT LDATICCGSC 

        70         80         90        100        110        120 
ALRYCCAAAD ARLEQGGCTN DRRELEHPGI TAQPVYVPFL IVGSIFIAFI ILGSVVAIYC 

       130        140        150        160        170        180 
CTCLRPKEPS QQPIRFSLRS YQTETLPMIL TSTSPRAPSR QSSTATSSSS TGGSIRRFSF 

       190        200        210        220        230 
ARAEPGCLVP SPPPPYTTSH SIHLAQPSGF LVSPQYFAYP LQQEPPLPGK SCPDFSSS 

« Hide

References

[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-13.
Tissue: Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471069 Genomic DNA. Translation: EAW93002.1.
BC012029 mRNA. Translation: AAH12029.1.
BC127690 mRNA. Translation: AAI27691.1.
BC127691 mRNA. Translation: AAI27692.1.
CCDSCCDS33979.1.
RefSeqNP_001073974.1. NM_001080505.1.
UniGeneHs.370904.

3D structure databases

ProteinModelPortalA0PJX4.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA0PJX4.

Proteomic databases

PaxDbA0PJX4.
PRIDEA0PJX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319234; ENSP00000326445; ENSG00000178343.
GeneID152573.
KEGGhsa:152573.
UCSCuc003gwp.3. human.

Organism-specific databases

CTD152573.
GeneCardsGC04P042399.
HGNCHGNC:25159. SHISA3.
HPAHPA054754.
neXtProtNX_A0PJX4.
PharmGKBPA162403293.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40940.
HOGENOMHOG000234350.
HOVERGENHBG059385.
InParanoidA0PJX4.
OMACTNDRGE.
OrthoDBEOG77M8PB.
PhylomeDBA0PJX4.
TreeFamTF330800.

Gene expression databases

BgeeA0PJX4.
CleanExHS_SHISA3.
GenevestigatorA0PJX4.

Family and domain databases

InterProIPR026910. Shisa.
[Graphical view]
PfamPF13908. Shisa. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi152573.
NextBio86980.
PROA0PJX4.

Entry information

Entry nameSHSA3_HUMAN
AccessionPrimary (citable) accession number: A0PJX4
Secondary accession number(s): A0PJX3, Q96EQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM