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A0PJX4

- SHSA3_HUMAN

UniProt

A0PJX4 - SHSA3_HUMAN

Protein

Protein shisa-3 homolog

Gene

SHISA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.By similarity

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein shisa-3 homolog
    Gene namesi
    Name:SHISA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25159. SHISA3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403293.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 238217Protein shisa-3 homologPRO_0000330025Add
    BLAST

    Proteomic databases

    PaxDbiA0PJX4.
    PRIDEiA0PJX4.

    PTM databases

    PhosphoSiteiA0PJX4.

    Expressioni

    Gene expression databases

    BgeeiA0PJX4.
    CleanExiHS_SHISA3.
    GenevestigatoriA0PJX4.

    Organism-specific databases

    HPAiHPA054754.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PJX4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 9877ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 238119CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi190 – 1956Poly-Pro

    Sequence similaritiesi

    Belongs to the shisa family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40940.
    HOGENOMiHOG000234350.
    HOVERGENiHBG059385.
    InParanoidiA0PJX4.
    OMAiCTNDRGE.
    OrthoDBiEOG77M8PB.
    PhylomeDBiA0PJX4.
    TreeFamiTF330800.

    Family and domain databases

    InterProiIPR026910. Shisa.
    [Graphical view]
    PfamiPF13908. Shisa. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A0PJX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRALLALCLL LGWLRWGPAG AQQSGEYCHG WVDVQGNYHE GFQCPEDFDT    50
    LDATICCGSC ALRYCCAAAD ARLEQGGCTN DRRELEHPGI TAQPVYVPFL 100
    IVGSIFIAFI ILGSVVAIYC CTCLRPKEPS QQPIRFSLRS YQTETLPMIL 150
    TSTSPRAPSR QSSTATSSSS TGGSIRRFSF ARAEPGCLVP SPPPPYTTSH 200
    SIHLAQPSGF LVSPQYFAYP LQQEPPLPGK SCPDFSSS 238
    Length:238
    Mass (Da):25,832
    Last modified:January 9, 2007 - v1
    Checksum:i8469E3758F61D22C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951V → G in AAH12029. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131W → C.1 Publication
    Corresponds to variant rs11733156 [ dbSNP | Ensembl ].
    VAR_042687

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471069 Genomic DNA. Translation: EAW93002.1.
    BC012029 mRNA. Translation: AAH12029.1.
    BC127690 mRNA. Translation: AAI27691.1.
    BC127691 mRNA. Translation: AAI27692.1.
    CCDSiCCDS33979.1.
    RefSeqiNP_001073974.1. NM_001080505.1.
    UniGeneiHs.370904.

    Genome annotation databases

    EnsembliENST00000319234; ENSP00000326445; ENSG00000178343.
    GeneIDi152573.
    KEGGihsa:152573.
    UCSCiuc003gwp.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471069 Genomic DNA. Translation: EAW93002.1 .
    BC012029 mRNA. Translation: AAH12029.1 .
    BC127690 mRNA. Translation: AAI27691.1 .
    BC127691 mRNA. Translation: AAI27692.1 .
    CCDSi CCDS33979.1.
    RefSeqi NP_001073974.1. NM_001080505.1.
    UniGenei Hs.370904.

    3D structure databases

    ProteinModelPortali A0PJX4.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A0PJX4.

    Proteomic databases

    PaxDbi A0PJX4.
    PRIDEi A0PJX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319234 ; ENSP00000326445 ; ENSG00000178343 .
    GeneIDi 152573.
    KEGGi hsa:152573.
    UCSCi uc003gwp.3. human.

    Organism-specific databases

    CTDi 152573.
    GeneCardsi GC04P042399.
    HGNCi HGNC:25159. SHISA3.
    HPAi HPA054754.
    neXtProti NX_A0PJX4.
    PharmGKBi PA162403293.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40940.
    HOGENOMi HOG000234350.
    HOVERGENi HBG059385.
    InParanoidi A0PJX4.
    OMAi CTNDRGE.
    OrthoDBi EOG77M8PB.
    PhylomeDBi A0PJX4.
    TreeFami TF330800.

    Miscellaneous databases

    GenomeRNAii 152573.
    NextBioi 86980.
    PROi A0PJX4.

    Gene expression databases

    Bgeei A0PJX4.
    CleanExi HS_SHISA3.
    Genevestigatori A0PJX4.

    Family and domain databases

    InterProi IPR026910. Shisa.
    [Graphical view ]
    Pfami PF13908. Shisa. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-13.
      Tissue: Prostate.

    Entry informationi

    Entry nameiSHSA3_HUMAN
    AccessioniPrimary (citable) accession number: A0PJX4
    Secondary accession number(s): A0PJX3, Q96EQ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3