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Protein

TLD domain-containing protein 2

Gene

TLDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
TLD domain-containing protein 2
Alternative name(s):
TBC/LysM-associated domain-containing protein 2
Gene namesi
Name:TLDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16112. TLDC2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25658.

Polymorphism and mutation databases

BioMutaiTLDC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215TLD domain-containing protein 2PRO_0000318690Add
BLAST

Proteomic databases

PaxDbiA0PJX2.
PRIDEiA0PJX2.

PTM databases

iPTMnetiA0PJX2.
PhosphoSiteiA0PJX2.

Expressioni

Gene expression databases

BgeeiENSG00000101342.
CleanExiHS_C20orf118.
ExpressionAtlasiA0PJX2. baseline and differential.
GenevisibleiA0PJX2. HS.

Organism-specific databases

HPAiHPA047468.

Interactioni

Protein-protein interaction databases

BioGridi126667. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliA0PJX2.
SMRiA0PJX2. Positions 51-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 215137TLDAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi26 – 327Poly-Glu

Sequence similaritiesi

Belongs to the OXR1 family.Curated
Contains 1 TLD domain.Curated

Phylogenomic databases

eggNOGiKOG2372. Eukaryota.
COG5142. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000195803.
HOVERGENiHBG057616.
InParanoidiA0PJX2.
OMAiRREQFCI.
OrthoDBiEOG091G0L15.
PhylomeDBiA0PJX2.
TreeFamiTF316541.

Family and domain databases

InterProiIPR006571. TLDc_dom.
[Graphical view]
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00584. TLDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PJX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGLRWRYTR LPSQVEDTLS GEEGNEEEEE EEAAPDPAAA PEDPTVPQLT
60 70 80 90 100
EASQVLSASE IRQLSFHFPP RVTGHPWSLV FCTSRDGFSL QSLYRRMEGC
110 120 130 140 150
SGPVLLVLRD QDGQIFGAFS SSAIRLSKGF YGTGETFLFS FSPQLKVFKW
160 170 180 190 200
TGSNSFFVKG DLDSLMMGSG SGRFGLWLDG DLFRGGSSPC PTFNNEVLAR
210
QEQFCIQELE AWLLS
Length:215
Mass (Da):23,912
Last modified:January 9, 2007 - v1
Checksum:i6245E8FAC2C16D15
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021G → R.
Corresponds to variant rs3748460 [ dbSNP | Ensembl ].
VAR_050439

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123544 mRNA. Translation: BAG53910.1.
BC127688 mRNA. Translation: AAI27689.1.
BC130646 mRNA. Translation: AAI30647.1.
BC130648 mRNA. Translation: AAI30649.1.
CCDSiCCDS33465.1.
RefSeqiNP_001291712.1. NM_001304783.1.
NP_542195.1. NM_080628.2.
UniGeneiHs.472630.

Genome annotation databases

EnsembliENST00000217320; ENSP00000217320; ENSG00000101342.
ENST00000602922; ENSP00000473323; ENSG00000101342.
GeneIDi140711.
KEGGihsa:140711.
UCSCiuc002xgg.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123544 mRNA. Translation: BAG53910.1.
BC127688 mRNA. Translation: AAI27689.1.
BC130646 mRNA. Translation: AAI30647.1.
BC130648 mRNA. Translation: AAI30649.1.
CCDSiCCDS33465.1.
RefSeqiNP_001291712.1. NM_001304783.1.
NP_542195.1. NM_080628.2.
UniGeneiHs.472630.

3D structure databases

ProteinModelPortaliA0PJX2.
SMRiA0PJX2. Positions 51-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126667. 5 interactions.

PTM databases

iPTMnetiA0PJX2.
PhosphoSiteiA0PJX2.

Polymorphism and mutation databases

BioMutaiTLDC2.

Proteomic databases

PaxDbiA0PJX2.
PRIDEiA0PJX2.

Protocols and materials databases

DNASUi140711.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217320; ENSP00000217320; ENSG00000101342.
ENST00000602922; ENSP00000473323; ENSG00000101342.
GeneIDi140711.
KEGGihsa:140711.
UCSCiuc002xgg.2. human.

Organism-specific databases

CTDi140711.
GeneCardsiTLDC2.
HGNCiHGNC:16112. TLDC2.
HPAiHPA047468.
neXtProtiNX_A0PJX2.
PharmGKBiPA25658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2372. Eukaryota.
COG5142. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000195803.
HOVERGENiHBG057616.
InParanoidiA0PJX2.
OMAiRREQFCI.
OrthoDBiEOG091G0L15.
PhylomeDBiA0PJX2.
TreeFamiTF316541.

Miscellaneous databases

GenomeRNAii140711.
PROiA0PJX2.

Gene expression databases

BgeeiENSG00000101342.
CleanExiHS_C20orf118.
ExpressionAtlasiA0PJX2. baseline and differential.
GenevisibleiA0PJX2. HS.

Family and domain databases

InterProiIPR006571. TLDc_dom.
[Graphical view]
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00584. TLDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLDC2_HUMAN
AccessioniPrimary (citable) accession number: A0PJX2
Secondary accession number(s): B3KVU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.