Reviewed, UniProtKB/Swiss-Prot A0PJX0 (CIB4_HUMAN)

Names and origin

Protein names

Recommended name:
    Calcium and integrin-binding family member 4

Gene names

Name:

CIB4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 3 EF-hand domains.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Calcium and integrin-binding family member 4		PRO_0000289290
Regions
	Domain	62 – 95	34	EF-hand 1
	Domain	97 – 132	36	EF-hand 2
	Domain	138 – 174	37	EF-hand 3
	Calcium binding	110 – 121	12	1 Potential
	Calcium binding	152 – 163	12	2 Potential
Natural variations
	Natural variant	181	1	H → R: dbSNP rs935172.		VAR_048637

Sequences

	Sequence		Length	Mass (Da)
	A0PJX0-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: A0DB9D75BF8F9724	FASTA	185	21,745
	10 20 30 40 50 60 MGQCLRYQMH WEDLEEYQAL TFLTRNEILC IHDTFLKLCP PGKYYKEATL TMDQVSSLPA 70 80 90 100 110 120 LRVNPFRDRI CRVFSHKGMF SFEDVLGMAS VFSEQACPSL KIEYAFRIYD FNENGFIDEE 130 140 150 160 170 180 DLQRIILRLL NSDDMSEDLL MDLTNHVLSE SDLDNDNMLS FSEFEHAMAK SPDFMNSFRI HFWGC

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC127684 mRNA. Translation: AAI27685.1. BC127685 mRNA. Translation: AAI27686.1.
IPI	IPI00046468.
RefSeq	NP_001025052.1.
UniGene	Hs.591579
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A0PJX0.
Genome annotation databases
Ensembl	ENSG00000157884. Homo sapiens. [Contig view]
GeneID	130106.
KEGG	hsa:130106.
Organism-specific databases
GeneCards	GC02M026716.
HGNC	HGNC:33703. CIB4.
MIM	610646. gene.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	A0PJX0.
OMA	A0PJX0. NEILCIH.
Gene expression databases
Bgee	A0PJX0.
CleanEx	HS_CIB4.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR018248. EF_hand. IPR018247. EF_HAND_1. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF00036. efhand. 1 hit. [Graphical view]
ProDom	PD000012. EF-hand. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	82703.
SOURCE	Search...

Entry information

Entry name

CIB4_HUMAN

Accession

Primary (citable) accession number: A0PJX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)