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Protein

Calcium and integrin-binding family member 4

Gene

CIB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi110 – 121121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi152 – 163122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium and integrin-binding family member 4
Gene namesi
Name:CIB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:33703. CIB4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382288.

Polymorphism and mutation databases

BioMutaiCIB4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Calcium and integrin-binding family member 4PRO_0000289290Add
BLAST

Proteomic databases

PaxDbiA0PJX0.
PRIDEiA0PJX0.

PTM databases

PhosphoSiteiA0PJX0.

Expressioni

Gene expression databases

BgeeiA0PJX0.
CleanExiHS_CIB4.
GenevisibleiA0PJX0. HS.

Organism-specific databases

HPAiHPA036130.
HPA036131.

Interactioni

Subunit structurei

Interacts with ITGA2B (via C-terminus cytoplasmic tail region); the interaction is stabilized/increased in a calcium- and magnesium-dependent manner.1 Publication

Protein-protein interaction databases

BioGridi126223. 2 interactions.
STRINGi9606.ENSP00000288861.

Structurei

3D structure databases

ProteinModelPortaliA0PJX0.
SMRiA0PJX0. Positions 12-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 9534EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini97 – 13236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 17437EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0034. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119179.
HOGENOMiHOG000233019.
HOVERGENiHBG107344.
InParanoidiA0PJX0.
OMAiFSHNNVF.
OrthoDBiEOG7KM5V7.
PhylomeDBiA0PJX0.
TreeFamiTF313865.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PJX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQCLRYQMH WEDLEEYQAL TFLTRNEILC IHDTFLKLCP PGKYYKEATL
60 70 80 90 100
TMDQVSSLPA LRVNPFRDRI CRVFSHKGMF SFEDVLGMAS VFSEQACPSL
110 120 130 140 150
KIEYAFRIYD FNENGFIDEE DLQRIILRLL NSDDMSEDLL MDLTNHVLSE
160 170 180
SDLDNDNMLS FSEFEHAMAK SPDFMNSFRI HFWGC
Length:185
Mass (Da):21,745
Last modified:January 9, 2007 - v1
Checksum:iA0DB9D75BF8F9724
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811H → R.2 Publications
Corresponds to variant rs935172 [ dbSNP | Ensembl ].
VAR_048637

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAX00680.1.
BC127684 mRNA. Translation: AAI27685.1.
BC127685 mRNA. Translation: AAI27686.1.
BC140923 mRNA. Translation: AAI40924.1.
CCDSiCCDS33160.1.
RefSeqiNP_001025052.1. NM_001029881.2.
UniGeneiHs.591579.

Genome annotation databases

EnsembliENST00000288861; ENSP00000288861; ENSG00000157884.
GeneIDi130106.
KEGGihsa:130106.
UCSCiuc002rhm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA. Translation: EAX00680.1.
BC127684 mRNA. Translation: AAI27685.1.
BC127685 mRNA. Translation: AAI27686.1.
BC140923 mRNA. Translation: AAI40924.1.
CCDSiCCDS33160.1.
RefSeqiNP_001025052.1. NM_001029881.2.
UniGeneiHs.591579.

3D structure databases

ProteinModelPortaliA0PJX0.
SMRiA0PJX0. Positions 12-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126223. 2 interactions.
STRINGi9606.ENSP00000288861.

PTM databases

PhosphoSiteiA0PJX0.

Polymorphism and mutation databases

BioMutaiCIB4.

Proteomic databases

PaxDbiA0PJX0.
PRIDEiA0PJX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288861; ENSP00000288861; ENSG00000157884.
GeneIDi130106.
KEGGihsa:130106.
UCSCiuc002rhm.4. human.

Organism-specific databases

CTDi130106.
GeneCardsiCIB4.
HGNCiHGNC:33703. CIB4.
HPAiHPA036130.
HPA036131.
MIMi610646. gene.
neXtProtiNX_A0PJX0.
PharmGKBiPA162382288.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0034. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000119179.
HOGENOMiHOG000233019.
HOVERGENiHBG107344.
InParanoidiA0PJX0.
OMAiFSHNNVF.
OrthoDBiEOG7KM5V7.
PhylomeDBiA0PJX0.
TreeFamiTF313865.

Miscellaneous databases

GenomeRNAii130106.
NextBioi82703.
PROiA0PJX0.
SOURCEiSearch...

Gene expression databases

BgeeiA0PJX0.
CleanExiHS_CIB4.
GenevisibleiA0PJX0. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-181.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-181.
    Tissue: Testis.
  3. "Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences."
    Huang H., Bogstie J.N., Vogel H.J.
    Biochem. Cell Biol. 90:646-656(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITGA2B, MAGNESIUM-BINDING, CALCIUM-BINDING.

Entry informationi

Entry nameiCIB4_HUMAN
AccessioniPrimary (citable) accession number: A0PJX0
Secondary accession number(s): B2RU18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: January 9, 2007
Last modified: May 11, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The binding of either calcium or magnesium may significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.