A0PJX0 (CIB4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium and integrin-binding family member 4

Gene names

Name:

CIB4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 3 EF-hand domains.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	Calcium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Calcium and integrin-binding family member 4		PRO_0000289290
Regions
	Domain	62 – 95	34	EF-hand 1
	Domain	97 – 132	36	EF-hand 2
	Domain	138 – 174	37	EF-hand 3
	Calcium binding	110 – 121	12	1 Potential
	Calcium binding	152 – 163	12	2 Potential
Natural variations
	Natural variant	181	1	H → R. Ref.1 Ref.2 Corresponds to variant rs935172 [ dbSNP | Ensembl ].		VAR_048637

Sequences

	Sequence		Length	Mass (Da)
	A0PJX0 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: A0DB9D75BF8F9724	FASTA	185	21,745
	10 20 30 40 50 60 MGQCLRYQMH WEDLEEYQAL TFLTRNEILC IHDTFLKLCP PGKYYKEATL TMDQVSSLPA 70 80 90 100 110 120 LRVNPFRDRI CRVFSHKGMF SFEDVLGMAS VFSEQACPSL KIEYAFRIYD FNENGFIDEE 130 140 150 160 170 180 DLQRIILRLL NSDDMSEDLL MDLTNHVLSE SDLDNDNMLS FSEFEHAMAK SPDFMNSFRI HFWGC

References

[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-181.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-181. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471053 Genomic DNA. Translation: EAX00680.1. BC127684 mRNA. Translation: AAI27685.1. BC127685 mRNA. Translation: AAI27686.1. BC140923 mRNA. Translation: AAI40924.1.
IPI	IPI00046468.
RefSeq	NP_001025052.1. NM_001029881.1.
UniGene	Hs.591579.
3D structure databases
ProteinModelPortal	A0PJX0.
SMR	A0PJX0. Positions 10-181.
ModBase	Search...
Protein-protein interaction databases
STRING	A0PJX0.
PTM databases
PhosphoSite	A0PJX0.
Proteomic databases
PRIDE	A0PJX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000288861; ENSP00000288861; ENSG00000157884.
GeneID	130106.
KEGG	hsa:130106.
UCSC	uc002rhm.1. human.
Organism-specific databases
CTD	130106.
GeneCards	GC02M026716.
HGNC	HGNC:33703. CIB4.
HPA	HPA036130.
MIM	610646. gene.
neXtProt	NX_A0PJX0.
PharmGKB	PA162382288.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11339.
GeneTree	ENSGT00600000084053.
HOVERGEN	HBG107344.
OMA	YKEATLT.
OrthoDB	EOG4K3KXM.
PhylomeDB	A0PJX0.
Gene expression databases
Bgee	A0PJX0.
CleanEx	HS_CIB4.
Genevestigator	A0PJX0.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca-bd. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	82703.
SOURCE	Search...

Entry information

Entry name

CIB4_HUMAN

Accession

Primary (citable) accession number: A0PJX0
Secondary accession number(s): B2RU18

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	January 9, 2007
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.