ID   DAPL1_HUMAN             Reviewed;         107 AA.
AC   A0PJW8; A0PJW9; B9EIK6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 2.
DT   24-JAN-2024, entry version 101.
DE   RecName: Full=Death-associated protein-like 1;
DE   AltName: Full=Early epithelial differentiation-associated protein;
GN   Name=DAPL1; Synonyms=EEDA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PRO-60.
RA   Schulz H.L., Stojic J., Weber B.H.F.;
RT   "Cloning and characterization of DAPL1.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-60.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RC   TISSUE=Corneal epithelium;
RX   PubMed=15920738; DOI=10.1002/jcp.20433;
RA   Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.;
RT   "EEDA: a protein associated with an early stage of stratified epithelial
RT   differentiation.";
RL   J. Cell. Physiol. 206:103-111(2006).
CC   -!- FUNCTION: May play a role in the early stages of epithelial
CC       differentiation or in apoptosis. {ECO:0000250}.
CC   -!- INTERACTION:
CC       A0PJW8; Q14192: FHL2; NbExp=3; IntAct=EBI-12840152, EBI-701903;
CC       A0PJW8; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-12840152, EBI-10242151;
CC       A0PJW8; O15116: LSM1; NbExp=3; IntAct=EBI-12840152, EBI-347619;
CC       A0PJW8; Q969E8: TSR2; NbExp=3; IntAct=EBI-12840152, EBI-746981;
CC       A0PJW8; Q15915: ZIC1; NbExp=3; IntAct=EBI-12840152, EBI-11963196;
CC   -!- TISSUE SPECIFICITY: Expressed in hair follicle (at protein level).
CC       {ECO:0000269|PubMed:15920738}.
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DR   EMBL; AY324399; AAQ93012.1; -; mRNA.
DR   EMBL; CH471058; EAX11424.1; -; Genomic_DNA.
DR   EMBL; BC127682; AAI27683.1; -; mRNA.
DR   EMBL; BC127683; AAI27684.1; -; mRNA.
DR   EMBL; BC140719; AAI40720.1; -; mRNA.
DR   CCDS; CCDS33307.1; -.
DR   RefSeq; NP_001017920.2; NM_001017920.2.
DR   AlphaFoldDB; A0PJW8; -.
DR   SMR; A0PJW8; -.
DR   BioGRID; 124918; 8.
DR   IntAct; A0PJW8; 7.
DR   STRING; 9606.ENSP00000309538; -.
DR   iPTMnet; A0PJW8; -.
DR   PhosphoSitePlus; A0PJW8; -.
DR   BioMuta; DAPL1; -.
DR   MassIVE; A0PJW8; -.
DR   PaxDb; 9606-ENSP00000309538; -.
DR   PeptideAtlas; A0PJW8; -.
DR   ProteomicsDB; 65; -.
DR   Antibodypedia; 54329; 134 antibodies from 18 providers.
DR   DNASU; 92196; -.
DR   Ensembl; ENST00000309950.8; ENSP00000309538.4; ENSG00000163331.12.
DR   GeneID; 92196; -.
DR   KEGG; hsa:92196; -.
DR   MANE-Select; ENST00000309950.8; ENSP00000309538.4; NM_001017920.3; NP_001017920.2.
DR   AGR; HGNC:21490; -.
DR   CTD; 92196; -.
DR   DisGeNET; 92196; -.
DR   GeneCards; DAPL1; -.
DR   HGNC; HGNC:21490; DAPL1.
DR   HPA; ENSG00000163331; Tissue enhanced (epididymis, esophagus, skin).
DR   neXtProt; NX_A0PJW8; -.
DR   OpenTargets; ENSG00000163331; -.
DR   PharmGKB; PA134982815; -.
DR   VEuPathDB; HostDB:ENSG00000163331; -.
DR   eggNOG; ENOG502S7Q6; Eukaryota.
DR   GeneTree; ENSGT00940000154574; -.
DR   HOGENOM; CLU_150759_0_0_1; -.
DR   InParanoid; A0PJW8; -.
DR   OMA; HKINAAA; -.
DR   OrthoDB; 5359993at2759; -.
DR   PhylomeDB; A0PJW8; -.
DR   TreeFam; TF329716; -.
DR   PathwayCommons; A0PJW8; -.
DR   SignaLink; A0PJW8; -.
DR   BioGRID-ORCS; 92196; 8 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 92196; -.
DR   Pharos; A0PJW8; Tbio.
DR   PRO; PR:A0PJW8; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A0PJW8; Protein.
DR   Bgee; ENSG00000163331; Expressed in upper arm skin and 132 other cell types or tissues.
DR   ExpressionAtlas; A0PJW8; baseline and differential.
DR   GO; GO:0070513; F:death domain binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; ISS:UniProtKB.
DR   GO; GO:0031369; F:translation initiation factor binding; ISS:UniProtKB.
DR   GO; GO:0030371; F:translation repressor activity; ISS:UniProtKB.
DR   GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:0010507; P:negative regulation of autophagy; IBA:GO_Central.
DR   GO; GO:2001186; P:negative regulation of CD8-positive, alpha-beta T cell activation; ISS:UniProtKB.
DR   GO; GO:0141014; P:ribosome hibernation; ISS:UniProtKB.
DR   InterPro; IPR024130; DAP1/DAPL1.
DR   PANTHER; PTHR13177; DEATH-ASSOCIATED PROTEIN 1; 1.
DR   PANTHER; PTHR13177:SF2; DEATH-ASSOCIATED PROTEIN-LIKE 1; 1.
DR   Pfam; PF15228; DAP; 1.
DR   Genevisible; A0PJW8; HS.
PE   1: Evidence at protein level;
KW   Apoptosis; Differentiation; Reference proteome.
FT   CHAIN           1..107
FT                   /note="Death-associated protein-like 1"
FT                   /id="PRO_0000316835"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         60
FT                   /note="L -> P (in dbSNP:rs9869)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT                   /id="VAR_038402"
FT   VARIANT         66
FT                   /note="A -> T (in dbSNP:rs12535)"
FT                   /id="VAR_038403"
SQ   SEQUENCE   107 AA;  11880 MW;  2BB99D8DEB3FC7C3 CRC64;
     MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA IANVAKIQTL
     DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI IQQPRKC
//