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Protein

Death-associated protein-like 1

Gene

DAPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the early stages of epithelial differentiation or in apoptosis.By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein-like 1
Alternative name(s):
Early epithelial differentiation-associated protein
Gene namesi
Name:DAPL1
Synonyms:EEDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:21490. DAPL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Death-associated protein-like 1PRO_0000316835Add
BLAST

Proteomic databases

PaxDbiA0PJW8.
PRIDEiA0PJW8.

PTM databases

PhosphoSiteiA0PJW8.

Expressioni

Tissue specificityi

Expressed in hair follicle (at protein level).1 Publication

Gene expression databases

BgeeiA0PJW8.
CleanExiHS_DAPL1.
ExpressionAtlasiA0PJW8. baseline and differential.
GenevestigatoriA0PJW8.

Organism-specific databases

HPAiHPA046937.

Structurei

3D structure databases

ProteinModelPortaliA0PJW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG84283.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiA0PJW8.
OMAiLSHKFPA.
OrthoDBiEOG7RZ5SD.
PhylomeDBiA0PJW8.
TreeFamiTF329716.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PJW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA
60 70 80 90 100
IANVAKIQTL DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI

IQQPRKC
Length:107
Mass (Da):11,880
Last modified:February 5, 2008 - v2
Checksum:i2BB99D8DEB3FC7C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601L → P.2 Publications
Corresponds to variant rs9869 [ dbSNP | Ensembl ].
VAR_038402
Natural varianti66 – 661A → T.
Corresponds to variant rs10497199 [ dbSNP | Ensembl ].
VAR_038403

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324399 mRNA. Translation: AAQ93012.1.
CH471058 Genomic DNA. Translation: EAX11424.1.
BC127682 mRNA. Translation: AAI27683.1.
BC127683 mRNA. Translation: AAI27684.1.
BC140719 mRNA. Translation: AAI40720.1.
CCDSiCCDS33307.1.
RefSeqiNP_001017920.2. NM_001017920.2.
UniGeneiHs.59761.

Genome annotation databases

EnsembliENST00000309950; ENSP00000309538; ENSG00000163331.
GeneIDi92196.
KEGGihsa:92196.
UCSCiuc002uaf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324399 mRNA. Translation: AAQ93012.1.
CH471058 Genomic DNA. Translation: EAX11424.1.
BC127682 mRNA. Translation: AAI27683.1.
BC127683 mRNA. Translation: AAI27684.1.
BC140719 mRNA. Translation: AAI40720.1.
CCDSiCCDS33307.1.
RefSeqiNP_001017920.2. NM_001017920.2.
UniGeneiHs.59761.

3D structure databases

ProteinModelPortaliA0PJW8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA0PJW8.

Proteomic databases

PaxDbiA0PJW8.
PRIDEiA0PJW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309950; ENSP00000309538; ENSG00000163331.
GeneIDi92196.
KEGGihsa:92196.
UCSCiuc002uaf.3. human.

Organism-specific databases

CTDi92196.
GeneCardsiGC02P159651.
HGNCiHGNC:21490. DAPL1.
HPAiHPA046937.
neXtProtiNX_A0PJW8.
PharmGKBiPA134982815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG84283.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
InParanoidiA0PJW8.
OMAiLSHKFPA.
OrthoDBiEOG7RZ5SD.
PhylomeDBiA0PJW8.
TreeFamiTF329716.

Miscellaneous databases

GenomeRNAii92196.
NextBioi77630.
PROiA0PJW8.

Gene expression databases

BgeeiA0PJW8.
CleanExiHS_DAPL1.
ExpressionAtlasiA0PJW8. baseline and differential.
GenevestigatoriA0PJW8.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of DAPL1."
    Schulz H.L., Stojic J., Weber B.H.F.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-60.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-60.
    Tissue: Brain.
  4. "EEDA: a protein associated with an early stage of stratified epithelial differentiation."
    Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.
    J. Cell. Physiol. 206:103-111(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Tissue: Corneal epithelium.

Entry informationi

Entry nameiDAPL1_HUMAN
AccessioniPrimary (citable) accession number: A0PJW8
Secondary accession number(s): A0PJW9, B9EIK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: January 7, 2015
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.