A0PJW8 (DAPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Death-associated protein-like 1

Alternative name(s):
Early epithelial differentiation-associated protein

Gene names

Name:	DAPL1
Synonyms:	EEDA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the early stages of epithelial differentiation or in apoptosis By similarity.
Tissue specificity	Expressed in hair follicle (at protein level). Ref.4

Ontologies

Keywords
Biological process	Apoptosis Differentiation
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Death-associated protein-like 1		PRO_0000316835
Natural variations
	Natural variant	60	1	L → P. Ref.1 Ref.3 Corresponds to variant rs9869 [ dbSNP | Ensembl ].		VAR_038402
	Natural variant	66	1	A → T. Corresponds to variant rs10497199 [ dbSNP | Ensembl ].		VAR_038403

Sequences

	Sequence		Length	Mass (Da)
	A0PJW8 [UniParc]. Last modified February 5, 2008. Version 2. Checksum: 2BB99D8DEB3FC7C3	FASTA	107	11,880
	10 20 30 40 50 60 MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA IANVAKIQTL 70 80 90 100 DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI IQQPRKC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of DAPL1." Schulz H.L., Stojic J., Weber B.H.F. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-60.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-60. Tissue: Brain.
[4]	"EEDA: a protein associated with an early stage of stratified epithelial differentiation." Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M. J. Cell. Physiol. 206:103-111(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY. Tissue: Corneal epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY324399 mRNA. Translation: AAQ93012.1. CH471058 Genomic DNA. Translation: EAX11424.1. BC127682 mRNA. Translation: AAI27683.1. BC127683 mRNA. Translation: AAI27684.1. BC140719 mRNA. Translation: AAI40720.1.
IPI	IPI00012682.
RefSeq	NP_001017920.2. NM_001017920.2.
UniGene	Hs.59761.
3D structure databases
ProteinModelPortal	A0PJW8.
ModBase	Search...
PTM databases
PhosphoSite	A0PJW8.
Proteomic databases
PaxDb	A0PJW8.
PRIDE	A0PJW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309950; ENSP00000309538; ENSG00000163331.
GeneID	92196.
KEGG	hsa:92196.
UCSC	uc002uaf.3. human.
Organism-specific databases
CTD	92196.
GeneCards	GC02P159651.
HGNC	HGNC:21490. DAPL1.
HPA	HPA046937.
neXtProt	NX_A0PJW8.
PharmGKB	PA134982815.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84283.
HOGENOM	HOG000039719.
HOVERGEN	HBG005451.
OMA	TMDALND.
OrthoDB	EOG4DBTGH.
PhylomeDB	A0PJW8.
Gene expression databases
ArrayExpress	A0PJW8.
Bgee	A0PJW8.
CleanEx	HS_DAPL1.
Genevestigator	A0PJW8.
Family and domain databases
InterPro	IPR024130. DAP1/DAPL1. [Graphical view]
PANTHER	PTHR13177. PTHR13177. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	92196.
NextBio	77630.

Entry information

Entry name

DAPL1_HUMAN

Accession

Primary (citable) accession number: A0PJW8
Secondary accession number(s): A0PJW9, B9EIK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	April 3, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.