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A0PJW8

- DAPL1_HUMAN

UniProt

A0PJW8 - DAPL1_HUMAN

Protein

Death-associated protein-like 1

Gene

DAPL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in the early stages of epithelial differentiation or in apoptosis.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis, Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Death-associated protein-like 1
    Alternative name(s):
    Early epithelial differentiation-associated protein
    Gene namesi
    Name:DAPL1
    Synonyms:EEDA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:21490. DAPL1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982815.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 107107Death-associated protein-like 1PRO_0000316835Add
    BLAST

    Proteomic databases

    PaxDbiA0PJW8.
    PRIDEiA0PJW8.

    PTM databases

    PhosphoSiteiA0PJW8.

    Expressioni

    Tissue specificityi

    Expressed in hair follicle (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiA0PJW8.
    BgeeiA0PJW8.
    CleanExiHS_DAPL1.
    GenevestigatoriA0PJW8.

    Organism-specific databases

    HPAiHPA046937.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PJW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG84283.
    HOGENOMiHOG000039719.
    HOVERGENiHBG005451.
    OMAiLSHKFPA.
    OrthoDBiEOG7RZ5SD.
    PhylomeDBiA0PJW8.
    TreeFamiTF329716.

    Family and domain databases

    InterProiIPR024130. DAP1/DAPL1.
    [Graphical view]
    PANTHERiPTHR13177. PTHR13177. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A0PJW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA    50
    IANVAKIQTL DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI 100
    IQQPRKC 107
    Length:107
    Mass (Da):11,880
    Last modified:February 5, 2008 - v2
    Checksum:i2BB99D8DEB3FC7C3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601L → P.2 Publications
    Corresponds to variant rs9869 [ dbSNP | Ensembl ].
    VAR_038402
    Natural varianti66 – 661A → T.
    Corresponds to variant rs10497199 [ dbSNP | Ensembl ].
    VAR_038403

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY324399 mRNA. Translation: AAQ93012.1.
    CH471058 Genomic DNA. Translation: EAX11424.1.
    BC127682 mRNA. Translation: AAI27683.1.
    BC127683 mRNA. Translation: AAI27684.1.
    BC140719 mRNA. Translation: AAI40720.1.
    CCDSiCCDS33307.1.
    RefSeqiNP_001017920.2. NM_001017920.2.
    UniGeneiHs.59761.

    Genome annotation databases

    EnsembliENST00000309950; ENSP00000309538; ENSG00000163331.
    GeneIDi92196.
    KEGGihsa:92196.
    UCSCiuc002uaf.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY324399 mRNA. Translation: AAQ93012.1 .
    CH471058 Genomic DNA. Translation: EAX11424.1 .
    BC127682 mRNA. Translation: AAI27683.1 .
    BC127683 mRNA. Translation: AAI27684.1 .
    BC140719 mRNA. Translation: AAI40720.1 .
    CCDSi CCDS33307.1.
    RefSeqi NP_001017920.2. NM_001017920.2.
    UniGenei Hs.59761.

    3D structure databases

    ProteinModelPortali A0PJW8.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A0PJW8.

    Proteomic databases

    PaxDbi A0PJW8.
    PRIDEi A0PJW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309950 ; ENSP00000309538 ; ENSG00000163331 .
    GeneIDi 92196.
    KEGGi hsa:92196.
    UCSCi uc002uaf.3. human.

    Organism-specific databases

    CTDi 92196.
    GeneCardsi GC02P159651.
    HGNCi HGNC:21490. DAPL1.
    HPAi HPA046937.
    neXtProti NX_A0PJW8.
    PharmGKBi PA134982815.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84283.
    HOGENOMi HOG000039719.
    HOVERGENi HBG005451.
    OMAi LSHKFPA.
    OrthoDBi EOG7RZ5SD.
    PhylomeDBi A0PJW8.
    TreeFami TF329716.

    Miscellaneous databases

    GenomeRNAii 92196.
    NextBioi 77630.
    PROi A0PJW8.

    Gene expression databases

    ArrayExpressi A0PJW8.
    Bgeei A0PJW8.
    CleanExi HS_DAPL1.
    Genevestigatori A0PJW8.

    Family and domain databases

    InterProi IPR024130. DAP1/DAPL1.
    [Graphical view ]
    PANTHERi PTHR13177. PTHR13177. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of DAPL1."
      Schulz H.L., Stojic J., Weber B.H.F.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-60.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-60.
      Tissue: Brain.
    4. "EEDA: a protein associated with an early stage of stratified epithelial differentiation."
      Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.
      J. Cell. Physiol. 206:103-111(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
      Tissue: Corneal epithelium.

    Entry informationi

    Entry nameiDAPL1_HUMAN
    AccessioniPrimary (citable) accession number: A0PJW8
    Secondary accession number(s): A0PJW9, B9EIK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3