Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A0PJW8 (DAPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Death-associated protein-like 1
Alternative name(s):
Early epithelial differentiation-associated protein
Gene names
Name:DAPL1
Synonyms:EEDA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length107 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the early stages of epithelial differentiation or in apoptosis By similarity.

Tissue specificity

Expressed in hair follicle (at protein level). Ref.4

Ontologies

Keywords
   Biological processApoptosis
Differentiation
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 107107Death-associated protein-like 1
PRO_0000316835

Natural variations

Natural variant601L → P. Ref.1 Ref.3
Corresponds to variant rs9869 [ dbSNP | Ensembl ].
VAR_038402
Natural variant661A → T.
Corresponds to variant rs10497199 [ dbSNP | Ensembl ].
VAR_038403

Sequences

Sequence LengthMass (Da)Tools
A0PJW8 [UniParc].

Last modified February 5, 2008. Version 2.
Checksum: 2BB99D8DEB3FC7C3

FASTA10711,880
        10         20         30         40         50         60 
MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA IANVAKIQTL 

        70         80         90        100 
DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI IQQPRKC 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of DAPL1."
Schulz H.L., Stojic J., Weber B.H.F.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-60.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-60.
Tissue: Brain.
[4]"EEDA: a protein associated with an early stage of stratified epithelial differentiation."
Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.
J. Cell. Physiol. 206:103-111(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
Tissue: Corneal epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY324399 mRNA. Translation: AAQ93012.1.
CH471058 Genomic DNA. Translation: EAX11424.1.
BC127682 mRNA. Translation: AAI27683.1.
BC127683 mRNA. Translation: AAI27684.1.
BC140719 mRNA. Translation: AAI40720.1.
RefSeqNP_001017920.2. NM_001017920.2.
UniGeneHs.59761.

3D structure databases

ProteinModelPortalA0PJW8.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA0PJW8.

Proteomic databases

PaxDbA0PJW8.
PRIDEA0PJW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309950; ENSP00000309538; ENSG00000163331.
GeneID92196.
KEGGhsa:92196.
UCSCuc002uaf.3. human.

Organism-specific databases

CTD92196.
GeneCardsGC02P159651.
HGNCHGNC:21490. DAPL1.
HPAHPA046937.
neXtProtNX_A0PJW8.
PharmGKBPA134982815.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84283.
HOGENOMHOG000039719.
HOVERGENHBG005451.
OMALSHKFPA.
OrthoDBEOG7RZ5SD.
PhylomeDBA0PJW8.
TreeFamTF329716.

Gene expression databases

ArrayExpressA0PJW8.
BgeeA0PJW8.
CleanExHS_DAPL1.
GenevestigatorA0PJW8.

Family and domain databases

InterProIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERPTHR13177. PTHR13177. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi92196.
NextBio77630.
PROA0PJW8.

Entry information

Entry nameDAPL1_HUMAN
AccessionPrimary (citable) accession number: A0PJW8
Secondary accession number(s): A0PJW9, B9EIK6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM