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A0PJW8

- DAPL1_HUMAN

UniProt

A0PJW8 - DAPL1_HUMAN

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Protein

Death-associated protein-like 1

Gene
DAPL1, EEDA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the early stages of epithelial differentiation or in apoptosis By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Death-associated protein-like 1
Alternative name(s):
Early epithelial differentiation-associated protein
Gene namesi
Name:DAPL1
Synonyms:EEDA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:21490. DAPL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Death-associated protein-like 1PRO_0000316835Add
BLAST

Proteomic databases

PaxDbiA0PJW8.
PRIDEiA0PJW8.

PTM databases

PhosphoSiteiA0PJW8.

Expressioni

Tissue specificityi

Expressed in hair follicle (at protein level).1 Publication

Gene expression databases

ArrayExpressiA0PJW8.
BgeeiA0PJW8.
CleanExiHS_DAPL1.
GenevestigatoriA0PJW8.

Organism-specific databases

HPAiHPA046937.

Structurei

3D structure databases

ProteinModelPortaliA0PJW8.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG84283.
HOGENOMiHOG000039719.
HOVERGENiHBG005451.
OMAiLSHKFPA.
OrthoDBiEOG7RZ5SD.
PhylomeDBiA0PJW8.
TreeFamiTF329716.

Family and domain databases

InterProiIPR024130. DAP1/DAPL1.
[Graphical view]
PANTHERiPTHR13177. PTHR13177. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PJW8-1 [UniParc]FASTAAdd to Basket

« Hide

MANEVQDLLS PRKGGHPPAV KAGGMRISKK QEIGTLERHT KKTGFEKTSA    50
IANVAKIQTL DALNDALEKL NYKFPATVHM AHQKPTPALE KVVPLKRIYI 100
IQQPRKC 107
Length:107
Mass (Da):11,880
Last modified:February 5, 2008 - v2
Checksum:i2BB99D8DEB3FC7C3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601L → P.2 Publications
Corresponds to variant rs9869 [ dbSNP | Ensembl ].
VAR_038402
Natural varianti66 – 661A → T.
Corresponds to variant rs10497199 [ dbSNP | Ensembl ].
VAR_038403

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY324399 mRNA. Translation: AAQ93012.1.
CH471058 Genomic DNA. Translation: EAX11424.1.
BC127682 mRNA. Translation: AAI27683.1.
BC127683 mRNA. Translation: AAI27684.1.
BC140719 mRNA. Translation: AAI40720.1.
CCDSiCCDS33307.1.
RefSeqiNP_001017920.2. NM_001017920.2.
UniGeneiHs.59761.

Genome annotation databases

EnsembliENST00000309950; ENSP00000309538; ENSG00000163331.
GeneIDi92196.
KEGGihsa:92196.
UCSCiuc002uaf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY324399 mRNA. Translation: AAQ93012.1 .
CH471058 Genomic DNA. Translation: EAX11424.1 .
BC127682 mRNA. Translation: AAI27683.1 .
BC127683 mRNA. Translation: AAI27684.1 .
BC140719 mRNA. Translation: AAI40720.1 .
CCDSi CCDS33307.1.
RefSeqi NP_001017920.2. NM_001017920.2.
UniGenei Hs.59761.

3D structure databases

ProteinModelPortali A0PJW8.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A0PJW8.

Proteomic databases

PaxDbi A0PJW8.
PRIDEi A0PJW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309950 ; ENSP00000309538 ; ENSG00000163331 .
GeneIDi 92196.
KEGGi hsa:92196.
UCSCi uc002uaf.3. human.

Organism-specific databases

CTDi 92196.
GeneCardsi GC02P159651.
HGNCi HGNC:21490. DAPL1.
HPAi HPA046937.
neXtProti NX_A0PJW8.
PharmGKBi PA134982815.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84283.
HOGENOMi HOG000039719.
HOVERGENi HBG005451.
OMAi LSHKFPA.
OrthoDBi EOG7RZ5SD.
PhylomeDBi A0PJW8.
TreeFami TF329716.

Miscellaneous databases

GenomeRNAii 92196.
NextBioi 77630.
PROi A0PJW8.

Gene expression databases

ArrayExpressi A0PJW8.
Bgeei A0PJW8.
CleanExi HS_DAPL1.
Genevestigatori A0PJW8.

Family and domain databases

InterProi IPR024130. DAP1/DAPL1.
[Graphical view ]
PANTHERi PTHR13177. PTHR13177. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of DAPL1."
    Schulz H.L., Stojic J., Weber B.H.F.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-60.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-60.
    Tissue: Brain.
  4. "EEDA: a protein associated with an early stage of stratified epithelial differentiation."
    Sun L., Ryan D.G., Zhou M., Sun T.-T., Lavker R.M.
    J. Cell. Physiol. 206:103-111(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Tissue: Corneal epithelium.

Entry informationi

Entry nameiDAPL1_HUMAN
AccessioniPrimary (citable) accession number: A0PJW8
Secondary accession number(s): A0PJW9, B9EIK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 9, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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