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Protein

Transmembrane protein 223

Gene

TMEM223

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 223
Gene namesi
Name:TMEM223
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28464. TMEM223.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726538.

Polymorphism and mutation databases

BioMutaiTMEM223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Transmembrane protein 223PRO_0000321833Add
BLAST

Proteomic databases

EPDiA0PJW6.
MaxQBiA0PJW6.
PaxDbiA0PJW6.
PRIDEiA0PJW6.

Expressioni

Gene expression databases

BgeeiA0PJW6.
ExpressionAtlasiA0PJW6. baseline and differential.
GenevisibleiA0PJW6. HS.

Organism-specific databases

HPAiHPA014504.

Interactioni

Protein-protein interaction databases

BioGridi122517. 29 interactions.
IntActiA0PJW6. 2 interactions.
STRINGi9606.ENSP00000303987.

Structurei

3D structure databases

ProteinModelPortaliA0PJW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM223 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWJD. Eukaryota.
ENOG4111M6M. LUCA.
GeneTreeiENSGT00390000012589.
HOGENOMiHOG000008386.
InParanoidiA0PJW6.
OMAiKQVSCMA.
PhylomeDBiA0PJW6.
TreeFamiTF324862.

Family and domain databases

InterProiIPR026100. Tmem223.
[Graphical view]
PANTHERiPTHR14549. PTHR14549. 1 hit.

Sequencei

Sequence statusi: Complete.

A0PJW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPWRRWPT GLLAVLRPLL TCRPLQGTTL QRDVLLFEHD RGRFFTILGL
60 70 80 90 100
FCAGQGVFWA SMAVAAVSRP PVPVQPLDAE VPNRGPFDLR SALWRYGLAV
110 120 130 140 150
GCGAIGALVL GAGLLFSLRS VRSVVLRAGG QQVTLTTHAP FGLGAHFTVP
160 170 180 190 200
LKQVSCMAHR GEVPAMLPLK VKGRRFYFLL DKTGHFPNTK LFDNTVGAYR

SL
Length:202
Mass (Da):22,049
Last modified:January 9, 2007 - v1
Checksum:iA233432FF880DAAC
GO

Sequence cautioni

The sequence AAH20914.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751R → S in AAH42801 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281T → A.1 Publication
Corresponds to variant rs2584918 [ dbSNP | Ensembl ].
VAR_039357
Natural varianti196 – 1961V → G.
Corresponds to variant rs11827177 [ dbSNP | Ensembl ].
VAR_039358

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW74102.1.
BC008643 mRNA. Translation: AAH08643.1.
BC020914 mRNA. Translation: AAH20914.1. Different initiation.
BC042801 mRNA. Translation: AAH42801.1.
BC094837 mRNA. Translation: AAH94837.1.
BC127679 mRNA. Translation: AAI27680.1.
CCDSiCCDS44628.1.
RefSeqiNP_001073970.1. NM_001080501.2.
UniGeneiHs.530463.

Genome annotation databases

EnsembliENST00000307366; ENSP00000303987; ENSG00000168569.
GeneIDi79064.
KEGGihsa:79064.
UCSCiuc001nve.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW74102.1.
BC008643 mRNA. Translation: AAH08643.1.
BC020914 mRNA. Translation: AAH20914.1. Different initiation.
BC042801 mRNA. Translation: AAH42801.1.
BC094837 mRNA. Translation: AAH94837.1.
BC127679 mRNA. Translation: AAI27680.1.
CCDSiCCDS44628.1.
RefSeqiNP_001073970.1. NM_001080501.2.
UniGeneiHs.530463.

3D structure databases

ProteinModelPortaliA0PJW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122517. 29 interactions.
IntActiA0PJW6. 2 interactions.
STRINGi9606.ENSP00000303987.

Polymorphism and mutation databases

BioMutaiTMEM223.

Proteomic databases

EPDiA0PJW6.
MaxQBiA0PJW6.
PaxDbiA0PJW6.
PRIDEiA0PJW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307366; ENSP00000303987; ENSG00000168569.
GeneIDi79064.
KEGGihsa:79064.
UCSCiuc001nve.3. human.

Organism-specific databases

CTDi79064.
GeneCardsiTMEM223.
H-InvDBHIX0035957.
HGNCiHGNC:28464. TMEM223.
HPAiHPA014504.
neXtProtiNX_A0PJW6.
PharmGKBiPA164726538.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWJD. Eukaryota.
ENOG4111M6M. LUCA.
GeneTreeiENSGT00390000012589.
HOGENOMiHOG000008386.
InParanoidiA0PJW6.
OMAiKQVSCMA.
PhylomeDBiA0PJW6.
TreeFamiTF324862.

Miscellaneous databases

ChiTaRSiTMEM223. human.
GenomeRNAii79064.
PROiA0PJW6.

Gene expression databases

BgeeiA0PJW6.
ExpressionAtlasiA0PJW6. baseline and differential.
GenevisibleiA0PJW6. HS.

Family and domain databases

InterProiIPR026100. Tmem223.
[Graphical view]
PANTHERiPTHR14549. PTHR14549. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-28.
    Tissue: Colon, Hippocampus and Lung.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM223_HUMAN
AccessioniPrimary (citable) accession number: A0PJW6
Secondary accession number(s): Q504S0
, Q86YD4, Q8WUC5, Q96HG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 9, 2007
Last modified: June 8, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.