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A0PJN4

- U2QL1_MOUSE

UniProt

A0PJN4 - U2QL1_MOUSE

Protein

Ubiquitin-conjugating enzyme E2Q-like protein 1

Gene

Ube2ql1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC:6.3.2.19)
    Gene namesi
    Name:Ube2ql1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1924230. Ube2ql1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 161161Ubiquitin-conjugating enzyme E2Q-like protein 1PRO_0000335812Add
    BLAST

    Proteomic databases

    PRIDEiA0PJN4.

    PTM databases

    PhosphoSiteiA0PJN4.

    Expressioni

    Gene expression databases

    ArrayExpressiA0PJN4.
    BgeeiA0PJN4.
    GenevestigatoriA0PJN4.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PJN4.
    SMRiA0PJN4. Positions 1-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG272407.
    HOGENOMiHOG000007757.
    HOVERGENiHBG061368.
    InParanoidiA0PJN4.
    KOiK10582.
    PhylomeDBiA0PJN4.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0PJN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKELQDIARL SDRFISVELV NENLFDWNVK LHQVDKDSVL WQDMKETNTE    50
    FILLNLTFPD NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA 100
    YTVEAVMRQF AASLVKGQGR ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK 150
    YGWVTPPVSD G 161
    Length:161
    Mass (Da):18,364
    Last modified:May 20, 2008 - v2
    Checksum:iA7DC159CFA09DA00
    GO

    Sequence cautioni

    The sequence AAI16980.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAI16982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331Q → P in AAH58543. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC058543 mRNA. Translation: AAH58543.1.
    BC116979 mRNA. Translation: AAI16980.1. Different initiation.
    BC116981 mRNA. Translation: AAI16982.1. Different initiation.
    RefSeqiNP_001138634.1. NM_001145162.1.
    UniGeneiMm.23960.

    Genome annotation databases

    GeneIDi76980.
    KEGGimmu:76980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC058543 mRNA. Translation: AAH58543.1 .
    BC116979 mRNA. Translation: AAI16980.1 . Different initiation.
    BC116981 mRNA. Translation: AAI16982.1 . Different initiation.
    RefSeqi NP_001138634.1. NM_001145162.1.
    UniGenei Mm.23960.

    3D structure databases

    ProteinModelPortali A0PJN4.
    SMRi A0PJN4. Positions 1-148.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A0PJN4.

    Proteomic databases

    PRIDEi A0PJN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 76980.
    KEGGi mmu:76980.

    Organism-specific databases

    CTDi 134111.
    MGIi MGI:1924230. Ube2ql1.

    Phylogenomic databases

    eggNOGi NOG272407.
    HOGENOMi HOG000007757.
    HOVERGENi HBG061368.
    InParanoidi A0PJN4.
    KOi K10582.
    PhylomeDBi A0PJN4.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 346228.
    PROi A0PJN4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A0PJN4.
    Bgeei A0PJN4.
    Genevestigatori A0PJN4.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiU2QL1_MOUSE
    AccessioniPrimary (citable) accession number: A0PJN4
    Secondary accession number(s): Q6PDR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3