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Protein

Ubiquitin-conjugating enzyme E2Q-like protein 1

Gene

Ube2ql1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathway:iprotein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC:6.3.2.19)
Gene namesi
Name:Ube2ql1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924230. Ube2ql1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Ubiquitin-conjugating enzyme E2Q-like protein 1PRO_0000335812Add
BLAST

Proteomic databases

PRIDEiA0PJN4.

PTM databases

PhosphoSiteiA0PJN4.

Expressioni

Gene expression databases

BgeeiA0PJN4.
ExpressionAtlasiA0PJN4. baseline and differential.
GenevisibleiA0PJN4. MM.

Interactioni

Subunit structurei

Interacts with FBXW7.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070906.

Structurei

3D structure databases

ProteinModelPortaliA0PJN4.
SMRiA0PJN4. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG272407.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiA0PJN4.
KOiK10582.
PhylomeDBiA0PJN4.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PJN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELQDIARL SDRFISVELV NENLFDWNVK LHQVDKDSVL WQDMKETNTE
60 70 80 90 100
FILLNLTFPD NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA
110 120 130 140 150
YTVEAVMRQF AASLVKGQGR ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK
160
YGWVTPPVSD G
Length:161
Mass (Da):18,364
Last modified:May 20, 2008 - v2
Checksum:iA7DC159CFA09DA00
GO

Sequence cautioni

The sequence AAI16980.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI16982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331Q → P in AAH58543 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058543 mRNA. Translation: AAH58543.1.
BC116979 mRNA. Translation: AAI16980.1. Different initiation.
BC116981 mRNA. Translation: AAI16982.1. Different initiation.
RefSeqiNP_001138634.1. NM_001145162.1.
UniGeneiMm.23960.

Genome annotation databases

GeneIDi76980.
KEGGimmu:76980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC058543 mRNA. Translation: AAH58543.1.
BC116979 mRNA. Translation: AAI16980.1. Different initiation.
BC116981 mRNA. Translation: AAI16982.1. Different initiation.
RefSeqiNP_001138634.1. NM_001145162.1.
UniGeneiMm.23960.

3D structure databases

ProteinModelPortaliA0PJN4.
SMRiA0PJN4. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070906.

PTM databases

PhosphoSiteiA0PJN4.

Proteomic databases

PRIDEiA0PJN4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76980.
KEGGimmu:76980.

Organism-specific databases

CTDi134111.
MGIiMGI:1924230. Ube2ql1.

Phylogenomic databases

eggNOGiNOG272407.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiA0PJN4.
KOiK10582.
PhylomeDBiA0PJN4.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi346228.
PROiA0PJN4.
SOURCEiSearch...

Gene expression databases

BgeeiA0PJN4.
ExpressionAtlasiA0PJN4. baseline and differential.
GenevisibleiA0PJN4. MM.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiU2QL1_MOUSE
AccessioniPrimary (citable) accession number: A0PJN4
Secondary accession number(s): Q6PDR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 22, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.