A0PJN4 (U2QL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-conjugating enzyme E2Q-like protein 1
EC=6.3.2.19

Gene names

Name:

Ube2ql1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins Potential.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.
Sequence caution	The sequence AAI16980.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAI16982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	Ubiquitin-conjugating enzyme E2Q-like protein 1		PRO_0000335812
Sites
	Active site	88	1	Glycyl thioester intermediate By similarity
Experimental info
	Sequence conflict	33	1	Q → P in AAH58543. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	A0PJN4 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: A7DC159CFA09DA00	FASTA	161	18,364
	10 20 30 40 50 60 MKELQDIARL SDRFISVELV NENLFDWNVK LHQVDKDSVL WQDMKETNTE FILLNLTFPD 70 80 90 100 110 120 NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA YTVEAVMRQF AASLVKGQGR 130 140 150 160 ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK YGWVTPPVSD G

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC058543 mRNA. Translation: AAH58543.1. BC116979 mRNA. Translation: AAI16980.1. Different initiation. BC116981 mRNA. Translation: AAI16982.1. Different initiation.
IPI	IPI00923085.
RefSeq	NP_001138634.1. NM_001145162.1.
UniGene	Mm.23960.
3D structure databases
ProteinModelPortal	A0PJN4.
SMR	A0PJN4. Positions 1-148.
ModBase	Search...
PTM databases
PhosphoSite	A0PJN4.
Proteomic databases
PRIDE	A0PJN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	76980.
KEGG	mmu:76980.
UCSC	uc007rcp.2. mouse.
Organism-specific databases
CTD	134111.
MGI	MGI:1924230. Ube2ql1.
Phylogenomic databases
eggNOG	NOG272407.
HOGENOM	HOG000007757.
HOVERGEN	HBG061368.
InParanoid	A0PJN4.
KO	K10582.
OrthoDB	EOG4QFWFB.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	A0PJN4.
Bgee	A0PJN4.
Genevestigator	A0PJN4.
Family and domain databases
Gene3D	3.10.110.10. 1 hit.
InterPro	IPR000608. UBQ-conjugat_E2. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. False negative. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	346228.
SOURCE	Search...

Entry information

Entry name

U2QL1_MOUSE

Accession

Primary (citable) accession number: A0PJN4
Secondary accession number(s): Q6PDR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	April 3, 2013
This is version 52 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program