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A0PJN4

- U2QL1_MOUSE

UniProt

A0PJN4 - U2QL1_MOUSE

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Protein
Ubiquitin-conjugating enzyme E2Q-like protein 1
Gene
Ube2ql1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins Reviewed prediction.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro

GO - Biological processi

  1. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2Q-like protein 1 (EC:6.3.2.19)
Gene namesi
Name:Ube2ql1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1924230. Ube2ql1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Ubiquitin-conjugating enzyme E2Q-like protein 1
PRO_0000335812Add
BLAST

Proteomic databases

PRIDEiA0PJN4.

PTM databases

PhosphoSiteiA0PJN4.

Expressioni

Gene expression databases

ArrayExpressiA0PJN4.
BgeeiA0PJN4.
GenevestigatoriA0PJN4.

Structurei

3D structure databases

ProteinModelPortaliA0PJN4.
SMRiA0PJN4. Positions 1-148.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG272407.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiA0PJN4.
KOiK10582.
PhylomeDBiA0PJN4.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PJN4-1 [UniParc]FASTAAdd to Basket

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MKELQDIARL SDRFISVELV NENLFDWNVK LHQVDKDSVL WQDMKETNTE    50
FILLNLTFPD NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA 100
YTVEAVMRQF AASLVKGQGR ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK 150
YGWVTPPVSD G 161
Length:161
Mass (Da):18,364
Last modified:May 20, 2008 - v2
Checksum:iA7DC159CFA09DA00
GO

Sequence cautioni

The sequence AAI16980.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAI16982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331Q → P in AAH58543. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC058543 mRNA. Translation: AAH58543.1.
BC116979 mRNA. Translation: AAI16980.1. Different initiation.
BC116981 mRNA. Translation: AAI16982.1. Different initiation.
RefSeqiNP_001138634.1. NM_001145162.1.
UniGeneiMm.23960.

Genome annotation databases

GeneIDi76980.
KEGGimmu:76980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC058543 mRNA. Translation: AAH58543.1 .
BC116979 mRNA. Translation: AAI16980.1 . Different initiation.
BC116981 mRNA. Translation: AAI16982.1 . Different initiation.
RefSeqi NP_001138634.1. NM_001145162.1.
UniGenei Mm.23960.

3D structure databases

ProteinModelPortali A0PJN4.
SMRi A0PJN4. Positions 1-148.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A0PJN4.

Proteomic databases

PRIDEi A0PJN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 76980.
KEGGi mmu:76980.

Organism-specific databases

CTDi 134111.
MGIi MGI:1924230. Ube2ql1.

Phylogenomic databases

eggNOGi NOG272407.
HOGENOMi HOG000007757.
HOVERGENi HBG061368.
InParanoidi A0PJN4.
KOi K10582.
PhylomeDBi A0PJN4.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 346228.
PROi A0PJN4.
SOURCEi Search...

Gene expression databases

ArrayExpressi A0PJN4.
Bgeei A0PJN4.
Genevestigatori A0PJN4.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiU2QL1_MOUSE
AccessioniPrimary (citable) accession number: A0PJN4
Secondary accession number(s): Q6PDR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: September 3, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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