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Protein

Dehydrogenase/reductase SDR family member 12

Gene

DHRS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei175 – 1751SubstrateSequence analysis
Active sitei201 – 2011Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 537NAD or NADPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 12 (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 40C member 11 Publication
Gene namesi
Name:DHRS12
Synonyms:SDR40C11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25832. DHRS12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358124.

Polymorphism and mutation databases

BioMutaiDHRS12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Dehydrogenase/reductase SDR family member 12PRO_0000312175Add
BLAST

Proteomic databases

PaxDbiA0PJE2.
PRIDEiA0PJE2.

Expressioni

Gene expression databases

BgeeiA0PJE2.
CleanExiHS_DHRS12.
ExpressionAtlasiA0PJE2. baseline and differential.
GenevisibleiA0PJE2. HS.

Organism-specific databases

HPAiCAB034238.
HPA057028.

Interactioni

Protein-protein interaction databases

BioGridi122867. 1 interaction.
STRINGi9606.ENSP00000280056.

Structurei

3D structure databases

ProteinModelPortaliA0PJE2.
SMRiA0PJE2. Positions 38-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG060423.
InParanoidiA0PJE2.
KOiK11168.
OMAiHVHIVDM.
OrthoDBiEOG7JMGDX.
PhylomeDBiA0PJE2.
TreeFamiTF353029.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0PJE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLYRSVVWF AKGLREYTKS GYESACKDFV PHDLEVQIPG RVFLVTGGNS
60 70 80 90 100
GIGKATALEI AKRGGTVHLV CRDQAPAEDA RGEIIRESGN QNIFLHIVDL
110 120 130 140 150
SDPKQIWKFV ENFKQEHKLH VLINNAGCMV NKRELTEDGL EKNFAANTLG
160 170 180 190 200
VYILTTGLIP VLEKEHDPRV ITVSSGGMLV QKLNTNDLQS ERTPFDGTMV
210 220 230 240 250
YAQNKRQQVV LTERWAQGHP AIHFSSMHPG WADTPGVRQA MPGFHARFGD
260 270 280 290 300
RLRSEAQGAD TMLWLALSSA AAAQPSGRFF QDRKPVSTHL PLATASSSPA
310
EEEKLIEILE QLAQTFK
Length:317
Mass (Da):35,146
Last modified:December 4, 2007 - v2
Checksum:iC5BCF344FB4625D4
GO
Isoform 2 (identifier: A0PJE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MSLYRSVVWF...GEIIRESGNQ → MNLHVKTLSL...KQLPLKSPSE
     282-296: DRKPVSTHLPLATAS → GDFLPGCEGS
     297-317: Missing.

Show »
Length:242
Mass (Da):27,145
Checksum:i9533DE5DF22E0577
GO
Isoform 3 (identifier: A0PJE2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MSLYRSVVWF...GEIIRESGNQ → MNLHVKTLSL...KQLPLKSPSE
     236-317: GVRQAMPGFH...ILEQLAQTFK → DRNEQELRKV...SSFLLYKQGN

Show »
Length:271
Mass (Da):30,850
Checksum:iC6B8905731FE9262
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9191MSLYR…ESGNQ → MNLHVKTLSLMTWRSRFLEE SFWSLEETAALAKQLPLKSP SE in isoform 2 and isoform 3. 2 PublicationsVSP_029724Add
BLAST
Alternative sequencei236 – 31782GVRQA…AQTFK → DRNEQELRKVVGEAQTASPL PRFLEIMMHEGKCQPQGHSS NDLEACWSSGGGEQNSLPDW PHQLHDLRQLTWALCSSFLL YKQGN in isoform 3. 1 PublicationVSP_029725Add
BLAST
Alternative sequencei282 – 29615DRKPV…LATAS → GDFLPGCEGS in isoform 2. 1 PublicationVSP_029726Add
BLAST
Alternative sequencei297 – 31721Missing in isoform 2. 1 PublicationVSP_029727Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023701 mRNA. Translation: BAB14646.1.
AL136525, AL162377 Genomic DNA. Translation: CAH70586.1.
AL162377, AL136525 Genomic DNA. Translation: CAI13427.1.
CH471075 Genomic DNA. Translation: EAX08884.1.
CH471075 Genomic DNA. Translation: EAX08888.1.
BC009825 mRNA. Translation: AAH09825.1.
BC026024 mRNA. Translation: AAH26024.1.
CCDSiCCDS31976.1. [A0PJE2-3]
CCDS58292.1. [A0PJE2-1]
CCDS9430.1. [A0PJE2-2]
RefSeqiNP_001026889.1. NM_001031719.2. [A0PJE2-3]
NP_001257353.1. NM_001270424.1. [A0PJE2-1]
NP_078981.1. NM_024705.2. [A0PJE2-2]
UniGeneiHs.266728.

Genome annotation databases

EnsembliENST00000218981; ENSP00000218981; ENSG00000102796. [A0PJE2-2]
ENST00000280056; ENSP00000280056; ENSG00000102796. [A0PJE2-3]
ENST00000444610; ENSP00000411565; ENSG00000102796. [A0PJE2-1]
GeneIDi79758.
KEGGihsa:79758.
UCSCiuc001vfq.5. human. [A0PJE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023701 mRNA. Translation: BAB14646.1.
AL136525, AL162377 Genomic DNA. Translation: CAH70586.1.
AL162377, AL136525 Genomic DNA. Translation: CAI13427.1.
CH471075 Genomic DNA. Translation: EAX08884.1.
CH471075 Genomic DNA. Translation: EAX08888.1.
BC009825 mRNA. Translation: AAH09825.1.
BC026024 mRNA. Translation: AAH26024.1.
CCDSiCCDS31976.1. [A0PJE2-3]
CCDS58292.1. [A0PJE2-1]
CCDS9430.1. [A0PJE2-2]
RefSeqiNP_001026889.1. NM_001031719.2. [A0PJE2-3]
NP_001257353.1. NM_001270424.1. [A0PJE2-1]
NP_078981.1. NM_024705.2. [A0PJE2-2]
UniGeneiHs.266728.

3D structure databases

ProteinModelPortaliA0PJE2.
SMRiA0PJE2. Positions 38-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122867. 1 interaction.
STRINGi9606.ENSP00000280056.

Polymorphism and mutation databases

BioMutaiDHRS12.

Proteomic databases

PaxDbiA0PJE2.
PRIDEiA0PJE2.

Protocols and materials databases

DNASUi79758.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218981; ENSP00000218981; ENSG00000102796. [A0PJE2-2]
ENST00000280056; ENSP00000280056; ENSG00000102796. [A0PJE2-3]
ENST00000444610; ENSP00000411565; ENSG00000102796. [A0PJE2-1]
GeneIDi79758.
KEGGihsa:79758.
UCSCiuc001vfq.5. human. [A0PJE2-1]

Organism-specific databases

CTDi79758.
GeneCardsiDHRS12.
HGNCiHGNC:25832. DHRS12.
HPAiCAB034238.
HPA057028.
MIMi616163. gene.
neXtProtiNX_A0PJE2.
PharmGKBiPA147358124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00760000119068.
HOVERGENiHBG060423.
InParanoidiA0PJE2.
KOiK11168.
OMAiHVHIVDM.
OrthoDBiEOG7JMGDX.
PhylomeDBiA0PJE2.
TreeFamiTF353029.

Miscellaneous databases

ChiTaRSiDHRS12. human.
GenomeRNAii79758.
NextBioi69215.
PROiA0PJE2.
SOURCEiSearch...

Gene expression databases

BgeeiA0PJE2.
CleanExiHS_DHRS12.
ExpressionAtlasiA0PJE2. baseline and differential.
GenevisibleiA0PJE2. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-317 (ISOFORM 1).
    Tissue: Kidney and Lung.
  5. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiDHR12_HUMAN
AccessioniPrimary (citable) accession number: A0PJE2
Secondary accession number(s): Q96GB2, Q9H8H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: April 13, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.