ID   A0PJA6_HUMAN            Unreviewed;       180 AA.
AC   A0PJA6;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=TF protein {ECO:0000313|EMBL:AAH20671.1};
DE   Flags: Fragment;
GN   Name=TF {ECO:0000313|EMBL:AAH20671.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH20671.1};
RN   [1] {ECO:0000313|EMBL:AAH20671.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:AAH20671.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC020671; AAH20671.1; -; mRNA.
DR   RefSeq; NP_001054.1; NM_001063.3.
DR   AlphaFoldDB; A0PJA6; -.
DR   MEROPS; S60.972; -.
DR   MEROPS; S60.975; -.
DR   PeptideAtlas; A0PJA6; -.
DR   DNASU; 7018; -.
DR   GeneID; 7018; -.
DR   KEGG; hsa:7018; -.
DR   CTD; 7018; -.
DR   PharmGKB; PA36457; -.
DR   BioGRID-ORCS; 7018; 18 hits in 1166 CRISPR screens.
DR   ChiTaRS; TF; human.
DR   GenomeRNAi; 7018; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0030120; C:vesicle coat; IDA:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006826; P:iron ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR   InterPro; IPR001156; Transferrin-like_dom.
DR   InterPro; IPR018195; Transferrin_Fe_BS.
DR   PANTHER; PTHR11485:SF31; SEROTRANSFERRIN; 1.
DR   PANTHER; PTHR11485; TRANSFERRIN; 1.
DR   Pfam; PF00405; Transferrin; 1.
DR   PRINTS; PR00422; TRANSFERRIN.
DR   SMART; SM00094; TR_FER; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   PROSITE; PS00206; TRANSFERRIN_LIKE_2; 1.
DR   PROSITE; PS00207; TRANSFERRIN_LIKE_3; 1.
DR   PROSITE; PS51408; TRANSFERRIN_LIKE_4; 1.
DR   Genevisible; A0PJA6; HS.
PE   2: Evidence at transcript level;
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          1..180
FT                   /note="Transferrin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51408"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH20671.1"
FT   NON_TER         180
FT                   /evidence="ECO:0000313|EMBL:AAH20671.1"
SQ   SEQUENCE   180 AA;  19908 MW;  FFDFD94034D072C5 CRC64;
     SGFQMNQLRG KKSCHTGLGR SAGWNIPIGL LYCDLPEPRK PLEKAVANFF SGSCAPCADG
     TDFPQLCQLC PGCGCSTLNQ YFGYSGAFKC LKDGAGDVAF VKHSTIFENL ANKADRDQYE
     LLCLDNTRKP VDEYKDCHLA QVPSHTVVAR SMGGKEDLIW ELLNQAQEHF GKKKKKKKKK
//