ID A0PGH6_DANRE Unreviewed; 2465 AA. AC A0PGH6; DT 09-JAN-2007, integrated into UniProtKB/TrEMBL. DT 09-JAN-2007, sequence version 1. DT 27-MAR-2024, entry version 128. DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142}; GN Name=notch1b {ECO:0000313|RefSeq:NP_571377.2, GN ECO:0000313|ZFIN:ZDB-GENE-990415-183}; GN Synonyms=etID309871.5 {ECO:0000313|RefSeq:NP_571377.2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAX19695.1}; RN [1] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=11066087; RA Stickney H.L., Barresi M.J., Devoto S.H.; RT "Somite development in zebrafish."; RL Dev. Dyn. 219:287-303(2000). RN [2] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=11099044; DOI=10.1038/35042590; RA Guo S., Yamaguchi Y., Schilbach S., Wada T., Lee J., Goddard A., French D., RA Handa H., Rosenthal A.; RT "A regulator of transcriptional elongation controls vertebrate neuronal RT development."; RL Nature 408:366-369(2000). RN [3] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=11466531; DOI=10.1007/s004270100159; RA Kortschak R.D., Tamme R., Lardelli M.; RT "Evolutionary analysis of vertebrate Notch genes."; RL Dev. Genes Evol. 211:350-354(2001). RN [4] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=11533493; DOI=10.1126/science.293.5535.1670; RA Walsh E.C., Stainier D.Y.; RT "UDP-glucose dehydrogenase required for cardiac valve formation in RT zebrafish."; RL Science 293:1670-1673(2001). RN [5] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=12909711; DOI=10.1073/pnas.1834204100; RA Raya A., Koth C.M., Buscher D., Kawakami Y., Itoh T., Raya R.M., RA Sternik G., Tsai H.J., Rodriguez-Esteban C., Izpisua-Belmonte J.C.; RT "Activation of Notch signaling pathway precedes heart regeneration in RT zebrafish."; RL Proc. Natl. Acad. Sci. U.S.A. 100 Suppl 1:11889-11895(2003). RN [6] {ECO:0000313|EMBL:AAX19695.1} RP NUCLEOTIDE SEQUENCE. RA Qiu X., Jiang Y.J.; RT "Sequence and function of zebrafish notch1b gene."; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [8] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=31042481; RA Xue Y., Liu D., Cui G., Ding Y., Ai D., Gao S., Zhang Y., Suo S., Wang X., RA Lv P., Zhou C., Li Y., Chen X., Peng G., Jing N., Han J.J., Liu F.; RT "A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi- RT dimensional RNA-Seq Analysis."; RL Cell Rep. 27:1567-1578(2019). RN [9] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=30729178; RA Maerz L.D., Burkhalter M.D., Schilpp C., Wittekindt O.H., Frick M., RA Philipp M.; RT "Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary RT function in developing zebrafish."; RL Commun. Biol. 2:31-31(2019). RN [10] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=30919514; RA Wang F., Yang Q., Wu F., Zhang Y., Sun S., Wang X., Gui Y., Li Q.; RT "Identification of a 42-bp heart-specific enhancer of the notch1b gene in RT zebrafish embryos."; RL Dev. Dyn. 248:426-436(2019). RN [11] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=30760708; DOI=10.1038/s41467-019-08590-7; RA Savage A.M., Kurusamy S., Chen Y., Jiang Z., Chhabria K., MacDonald R.B., RA Kim H.R., Wilson H.L., van Eeden F.J.M., Armesilla A.L., Chico T.J.A., RA Wilkinson R.N.; RT "tmem33 is essential for VEGF-mediated endothelial calcium oscillations and RT angiogenesis."; RL Nat. Commun. 10:732-732(2019). RN [12] {ECO:0000313|RefSeq:NP_571377.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=31110923; RA Tuttle M., Dalman M.R., Liu Q., Londraville R.L.; RT "Leptin-a mediates transcription of genes that participate in central RT endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic RT zebrafish (Danio rerio)."; RL PeerJ 7:e6848-e6848(2019). RN [13] {ECO:0000313|RefSeq:NP_571377.2} RP IDENTIFICATION. RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the NOTCH family. CC {ECO:0000256|ARBA:ARBA00005847}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY805407; AAX19695.1; -; mRNA. DR RefSeq; NP_571377.2; NM_131302.2. DR GeneID; 794892; -. DR KEGG; dre:794892; -. DR AGR; ZFIN:ZDB-GENE-990415-183; -. DR CTD; 794892; -. DR ZFIN; ZDB-GENE-990415-183; notch1b. DR OrthoDB; 5473534at2759; -. DR PhylomeDB; A0PGH6; -. DR SignaLink; A0PGH6; -. DR Proteomes; UP000000437; Chromosome 5. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0032991; C:protein-containing complex; IBA:GO_Central. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW. DR GO; GO:0060840; P:artery development; IMP:ZFIN. DR GO; GO:0001568; P:blood vessel development; IMP:ZFIN. DR GO; GO:0035907; P:dorsal aorta development; IGI:ZFIN. DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central. DR GO; GO:0031101; P:fin regeneration; IMP:ZFIN. DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:ZFIN. DR GO; GO:0060218; P:hematopoietic stem cell differentiation; IMP:ZFIN. DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central. DR GO; GO:0001946; P:lymphangiogenesis; IMP:ZFIN. DR GO; GO:0097150; P:neuronal stem cell population maintenance; IMP:ZFIN. DR GO; GO:0007219; P:Notch signaling pathway; IMP:ZFIN. DR GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; IGI:ZFIN. DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR GO; GO:0021654; P:rhombomere boundary formation; IGI:ZFIN. DR GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IGI:ZFIN. DR CDD; cd00054; EGF_CA; 27. DR CDD; cd21702; JMTM_Notch1; 1. DR Gene3D; 3.30.300.320; -; 1. DR Gene3D; 3.30.70.3310; -; 1. DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1. DR Gene3D; 2.10.25.10; Laminin; 34. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR008297; Notch. DR InterPro; IPR035993; Notch-like_dom_sf. DR InterPro; IPR022362; Notch_1. DR InterPro; IPR024600; Notch_C. DR InterPro; IPR000800; Notch_dom. DR InterPro; IPR010660; Notch_NOD_dom. DR InterPro; IPR011656; Notch_NODP_dom. DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1. DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1. DR Pfam; PF12796; Ank_2; 2. DR Pfam; PF00008; EGF; 20. DR Pfam; PF07645; EGF_CA; 5. DR Pfam; PF12661; hEGF; 4. DR Pfam; PF06816; NOD; 1. DR Pfam; PF07684; NODP; 1. DR Pfam; PF00066; Notch; 3. DR PIRSF; PIRSF002279; Notch; 2. DR PRINTS; PR00010; EGFBLOOD. DR PRINTS; PR01452; LNOTCHREPEAT. DR PRINTS; PR01983; NOTCH. DR PRINTS; PR01984; NOTCH1. DR SMART; SM00248; ANK; 6. DR SMART; SM01334; DUF3454; 1. DR SMART; SM00181; EGF; 35. DR SMART; SM00179; EGF_CA; 31. DR SMART; SM00004; NL; 3. DR SMART; SM01338; NOD; 1. DR SMART; SM01339; NODP; 1. DR SUPFAM; SSF48403; Ankyrin repeat; 1. DR SUPFAM; SSF57196; EGF/Laminin; 17. DR SUPFAM; SSF57184; Growth factor receptor domain; 5. DR SUPFAM; SSF90193; Notch domain; 3. DR PROSITE; PS50297; ANK_REP_REGION; 4. DR PROSITE; PS50088; ANK_REPEAT; 4. DR PROSITE; PS00010; ASX_HYDROXYL; 23. DR PROSITE; PS00022; EGF_1; 32. DR PROSITE; PS01186; EGF_2; 25. DR PROSITE; PS50026; EGF_3; 35. DR PROSITE; PS01187; EGF_CA; 9. DR PROSITE; PS50258; LNR; 3. PE 2: Evidence at transcript level; KW Activator {ECO:0000256|ARBA:ARBA00023159}; KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657}; KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE- KW ProRule:PRU00023}; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR002279-1}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW Differentiation {ECO:0000256|ARBA:ARBA00022782}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR002279-2}; KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE- KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1}; KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..2465 FT /note="Neurogenic locus notch homolog protein 1" FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_571377.2" FT /id="PRO_5035036325" FT DOMAIN 19..55 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 56..96 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 99..136 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 137..173 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 175..213 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 215..257 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 277..313 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 315..353 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 355..391 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 392..430 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 432..470 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 472..508 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 510..546 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 548..584 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 586..621 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 623..659 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 661..696 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 698..734 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 736..771 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 773..809 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 811..847 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 849..885 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 887..923 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 925..961 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 963..999 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1001..1037 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1039..1075 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1088..1123 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1125..1161 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1163..1199 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1201..1245 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1247..1282 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1284..1323 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1325..1361 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1364..1402 FT /note="EGF-like" FT /evidence="ECO:0000259|PROSITE:PS50026" FT DOMAIN 1426..1466 FT /note="LNR" FT /evidence="ECO:0000259|PROSITE:PS50258" FT DOMAIN 1467..1504 FT /note="LNR" FT /evidence="ECO:0000259|PROSITE:PS50258" FT DOMAIN 1505..1548 FT /note="LNR" FT /evidence="ECO:0000259|PROSITE:PS50258" FT REPEAT 1905..1937 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 1972..2004 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 2005..2037 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REPEAT 2038..2070 FT /note="ANK" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023" FT REGION 1747..1803 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2121..2164 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2376..2465 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1752..1768 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2121..2135 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2139..2161 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2376..2412 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2424..2465 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 452 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 455 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 472 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 475 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 489 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 490 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 510 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 511 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 513 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 527 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT BINDING 528 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1" FT DISULFID 23..33 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 45..54 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 86..95 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 126..135 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 163..172 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 203..212 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 303..312 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 343..352 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 381..390 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 401..418 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 420..429 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 436..449 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2" FT DISULFID 443..458 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2" FT DISULFID 460..469 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 476..487 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2" FT DISULFID 481..496 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2" FT DISULFID 498..507 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 514..525 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2" FT DISULFID 519..534 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2" FT DISULFID 536..545 FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 574..583 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 590..600 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 611..620 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 649..658 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 665..675 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 686..695 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 724..733 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 740..750 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 761..770 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 799..808 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 837..846 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 875..884 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 913..922 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 951..960 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 989..998 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1027..1036 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1065..1074 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1113..1122 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1151..1160 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1189..1198 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1235..1244 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1251..1261 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1272..1281 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1313..1322 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1351..1360 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1373..1390 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" FT DISULFID 1392..1401 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076" SQ SEQUENCE 2465 AA; 267589 MW; A58F9D8A2D519F7F CRC64; MHLFFVKLIV VISLNTLTQG LECSEKCQNG GTCEPTADGR GECKCLDLYA GPACQFRNPC FQSPCRNGGV CRLITSANKV DFVCNCSLGY TDRLCLTPTN NVCLGAPCRN GGTCELTSIH NYRCKCPPGW SGKTCQQADP CASNPCANGG QCSPFDSDFL CHCTPYFSGQ TCKQDVNECA QIPSPCKNGG VCENGVGTYH CNCPAEYTGK HCESLYQPCN PSPCLHGGTC VQKGETSYEC SCLPGRQEFV LIMRKCLNDY FLMLVFIGFS GQNCEENIDD CPDHRCLNGG TCVDGVNTYN CQCKPEWTGQ FCTEDVNECD LMPNSCQNGG TCLNTQGGYN CVCVNGWTGD DCSENIDDCA DAACHTGATC HDRVASFLCE CPHGRTGLLC HLDDACISNP CQKGSNCDTN PVNGKAICTC PLGYVGPACD QDVDECSLGA NPCEHAGKCI NTKGSFQCKC LQGYVGARCE LDINECLSTP CQNDATCLDQ IGGFHCICMP GYEGVFCQIN TDECASMPCL NNGKCIDKIN NYQCECPTGF SGSQCQFDID ECASTPCKNG AKCMDGPNMY TCQCTEGYTG QHCETDVDEC LSNPCHYGTC KDGLASFTCV CRAGFMGRLC EININECLSQ PCQNGGTCQD RENAYLCVCP KGTAGANCEI NLDDCQSNPC DFGRCIDKIN GYECACEPGY TGKMCNVNID ECAINPCHNG GTCVDGVNGF TCLCREGYHD TTCQSQLNEC LSNPCIHGHC EDKVNGYNCI CDSGWSGVNC DINNNECESN PCMNGGTCKD MTSGYVCTCR AGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGQTCEVDI NECVKNPCRN DAICQNSIGS YKCSCKAGYT GRNCETDIDD CKPNPCSNGG FCKDAVNAFT CTCLPGFRGG RCEEDINECE SNPCKNGANC TDCVNSYTCT CPPGFSGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP KGFTGNYCQH DINECDSRPC MNGGTCQDSY GTYKCTCPQG YHGLNCQELV NWCKPSPCKN GGICRQSGTR YSCQCQTGWT GLYCDVPSVS CEVAAKQQGV DVVRLCRNSG QCLDAGNTHY CHCQAGYTGS YCEEQVDECI PNPCQNGATC TDYLGGYSCE CVPGYHGVNC SDEINECLSQ PCQNGGTCID LINTYKCSCP RGTQGVHCEI NIDDCTPFTD PITHEPKCFN QGRCVDRVGG YHCICPPGYV GERCEGDVNE CLSNPCGTHS CIQLKNNYRC ECRTGYTGQH CDKVFDGCKG KPCRNGGTCA VASNTPHGFI CKCPPGFTGS TCEYDAHACG SLQCKNGGTC VSGHKSPKCL CTPAFTGPEC QDPSGGHCTT NPCYNGGTCE YITEEPYYHC ICPTNFNGLF CHILDWSFPG GTGQDITPAP KVSVSCEIEQ CKVKKGNKIC DSACNNYACD WDGGDCSLNF NDPWKNCSAA LQCWRYFNNG KCDEQCHNTG CLYDGFDCQR VEAQCNPLYD QYCKDHFADG YCDQGCNNAE CEWDGLDCAN DTPEKLAAGL LVVVVHIHPD QLRNNSFGFL RELSRVLHTN VVFRRDSKGQ EMIYPYYGNE QELKKHNIKR SLDGWNDASS DVLSSMKNSI YNIVVEGGRK RRELEKIQVK GSVVYLEIDN RQCYQQTSEC FQSANDAAAF LGALASSGSL KMPYVIEAVT SEIDGPSPVE LYPVYVVLAG LALLAFVAIG MVASRKRRRE HGQLWFPEGF KTSEPSKKKR REPVGEDSVG LRPLKNCSDI SLMDDNQNEW GEEEQSDSKR FRSEEQAMLD LDDQPDHRQW TQQHLDAADL RIPSIAPTPP QGEIENDCMD VNARGPDGFT PLMIASCSGG GLETGNSEEE EDASANVIND FIYQGANLHN QTDRTGETAL HLAARYARSD AAKRLLEASA DANIQDNMGR TPLHAAVAAD AQGVFQILIR NRATDLDARM HDGTTPLILA ARLAVEGMVE ELINCHADVN AIDDFGKSAL HWAAAVNNVD AAMVLLKNGA NKDMQNNKEE TPLFLAAREG SYETAKVLLE HFANREITDH MDRLPRDIAQ DRMHHDIVRL IDEYNLVRSP PMHSAPLCTT LSPPLCSPNG FMGNMKPSVQ SKKPRKPSTK GIGCKDGKDM KVKKKKAQDG KGNLLDSSAV LSPVDSLESP HGYISDIASP PQMTSPFQQS PSMSLNQLQG MSDNHMGVSH LGIGNNQDLS HIQFDPLPPR LTHLPVAGSN GSNVMNGQCE WLERMHGSMA PQNQFTAMRN ASGQANLHQS GLMTSHHNGR PATLSQMMNY QSMQNTHLMQ QMQQSMQPRP QQTGVQLQSQ SQNFIGGDLG GPELQQSAGN SMSIHTIIPQ ETQLLNPSSL GSSMAGTQFL TPPSQHSYTP ALDANTPNHQ LQVPDHHPFL TPSPGSPDQW SSSSPNSNMS DWSEGISSPP TSMQSQIGHM PEQFK //