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A0PGH6

- A0PGH6_DANRE

UniProt

A0PGH6 - A0PGH6_DANRE

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Protein
Submitted name: Notch1b
Gene
notch1b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. receptor activity Source: InterPro

GO - Biological processi

  1. Notch signaling pathway Source: InterPro
  2. cell differentiation Source: InterPro
  3. multicellular organismal development Source: InterPro
  4. regulation of developmental process Source: InterPro
  5. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Notch1bImported
Gene namesi
Name:notch1bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-183. notch1b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliA0PGH6.
SMRiA0PGH6. Positions 431-546, 1860-2100.

Family & Domainsi

Sequence similaritiesi

Contains 6 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, EGF-like domainUniRule annotationSAAS annotations, RepeatUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000234369.
HOVERGENiHBG052650.
InParanoidiA0PGH6.
KOiK02599.
PhylomeDBiA0PGH6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR022362. Notch_1.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 20 hits.
PF07645. EGF_CA. 5 hits.
PF12661. hEGF. 1 hit.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PIRSFiPIRSF002279. Notch. 1 hit.
PRINTSiPR01452. LNOTCHREPEAT.
PR01984. NOTCH1.
SMARTiSM00248. ANK. 6 hits.
SM00181. EGF. 11 hits.
SM00179. EGF_CA. 24 hits.
SM00004. NL. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS00010. ASX_HYDROXYL. 23 hits.
PS00022. EGF_1. 32 hits.
PS01186. EGF_2. 25 hits.
PS50026. EGF_3. 35 hits.
PS01187. EGF_CA. 22 hits.
PS50258. LNR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PGH6-1 [UniParc]FASTAAdd to Basket

« Hide

MHLFFVKLIV VISLNTLTQG LECSEKCQNG GTCEPTADGR GECKCLDLYA     50
GPACQFRNPC FQSPCRNGGV CRLITSANKV DFVCNCSLGY TDRLCLTPTN 100
NVCLGAPCRN GGTCELTSIH NYRCKCPPGW SGKTCQQADP CASNPCANGG 150
QCSPFDSDFL CHCTPYFSGQ TCKQDVNECA QIPSPCKNGG VCENGVGTYH 200
CNCPAEYTGK HCESLYQPCN PSPCLHGGTC VQKGETSYEC SCLPGRQEFV 250
LIMRKCLNDY FLMLVFIGFS GQNCEENIDD CPDHRCLNGG TCVDGVNTYN 300
CQCKPEWTGQ FCTEDVNECD LMPNSCQNGG TCLNTQGGYN CVCVNGWTGD 350
DCSENIDDCA DAACHTGATC HDRVASFLCE CPHGRTGLLC HLDDACISNP 400
CQKGSNCDTN PVNGKAICTC PLGYVGPACD QDVDECSLGA NPCEHAGKCI 450
NTKGSFQCKC LQGYVGARCE LDINECLSTP CQNDATCLDQ IGGFHCICMP 500
GYEGVFCQIN TDECASMPCL NNGKCIDKIN NYQCECPTGF SGSQCQFDID 550
ECASTPCKNG AKCMDGPNMY TCQCTEGYTG QHCETDVDEC LSNPCHYGTC 600
KDGLASFTCV CRAGFMGRLC EININECLSQ PCQNGGTCQD RENAYLCVCP 650
KGTAGANCEI NLDDCQSNPC DFGRCIDKIN GYECACEPGY TGKMCNVNID 700
ECAINPCHNG GTCVDGVNGF TCLCREGYHD TTCQSQLNEC LSNPCIHGHC 750
EDKVNGYNCI CDSGWSGVNC DINNNECESN PCMNGGTCKD MTSGYVCTCR 800
AGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGQTCEVDI 850
NECVKNPCRN DAICQNSIGS YKCSCKAGYT GRNCETDIDD CKPNPCSNGG 900
FCKDAVNAFT CTCLPGFRGG RCEEDINECE SNPCKNGANC TDCVNSYTCT 950
CPPGFSGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP KGFTGNYCQH 1000
DINECDSRPC MNGGTCQDSY GTYKCTCPQG YHGLNCQELV NWCKPSPCKN 1050
GGICRQSGTR YSCQCQTGWT GLYCDVPSVS CEVAAKQQGV DVVRLCRNSG 1100
QCLDAGNTHY CHCQAGYTGS YCEEQVDECI PNPCQNGATC TDYLGGYSCE 1150
CVPGYHGVNC SDEINECLSQ PCQNGGTCID LINTYKCSCP RGTQGVHCEI 1200
NIDDCTPFTD PITHEPKCFN QGRCVDRVGG YHCICPPGYV GERCEGDVNE 1250
CLSNPCGTHS CIQLKNNYRC ECRTGYTGQH CDKVFDGCKG KPCRNGGTCA 1300
VASNTPHGFI CKCPPGFTGS TCEYDAHACG SLQCKNGGTC VSGHKSPKCL 1350
CTPAFTGPEC QDPSGGHCTT NPCYNGGTCE YITEEPYYHC ICPTNFNGLF 1400
CHILDWSFPG GTGQDITPAP KVSVSCEIEQ CKVKKGNKIC DSACNNYACD 1450
WDGGDCSLNF NDPWKNCSAA LQCWRYFNNG KCDEQCHNTG CLYDGFDCQR 1500
VEAQCNPLYD QYCKDHFADG YCDQGCNNAE CEWDGLDCAN DTPEKLAAGL 1550
LVVVVHIHPD QLRNNSFGFL RELSRVLHTN VVFRRDSKGQ EMIYPYYGNE 1600
QELKKHNIKR SLDGWNDASS DVLSSMKNSI YNIVVEGGRK RRELEKIQVK 1650
GSVVYLEIDN RQCYQQTSEC FQSANDAAAF LGALASSGSL KMPYVIEAVT 1700
SEIDGPSPVE LYPVYVVLAG LALLAFVAIG MVASRKRRRE HGQLWFPEGF 1750
KTSEPSKKKR REPVGEDSVG LRPLKNCSDI SLMDDNQNEW GEEEQSDSKR 1800
FRSEEQAMLD LDDQPDHRQW TQQHLDAADL RIPSIAPTPP QGEIENDCMD 1850
VNARGPDGFT PLMIASCSGG GLETGNSEEE EDASANVIND FIYQGANLHN 1900
QTDRTGETAL HLAARYARSD AAKRLLEASA DANIQDNMGR TPLHAAVAAD 1950
AQGVFQILIR NRATDLDARM HDGTTPLILA ARLAVEGMVE ELINCHADVN 2000
AIDDFGKSAL HWAAAVNNVD AAMVLLKNGA NKDMQNNKEE TPLFLAAREG 2050
SYETAKVLLE HFANREITDH MDRLPRDIAQ DRMHHDIVRL IDEYNLVRSP 2100
PMHSAPLCTT LSPPLCSPNG FMGNMKPSVQ SKKPRKPSTK GIGCKDGKDM 2150
KVKKKKAQDG KGNLLDSSAV LSPVDSLESP HGYISDIASP PQMTSPFQQS 2200
PSMSLNQLQG MSDNHMGVSH LGIGNNQDLS HIQFDPLPPR LTHLPVAGSN 2250
GSNVMNGQCE WLERMHGSMA PQNQFTAMRN ASGQANLHQS GLMTSHHNGR 2300
PATLSQMMNY QSMQNTHLMQ QMQQSMQPRP QQTGVQLQSQ SQNFIGGDLG 2350
GPELQQSAGN SMSIHTIIPQ ETQLLNPSSL GSSMAGTQFL TPPSQHSYTP 2400
ALDANTPNHQ LQVPDHHPFL TPSPGSPDQW SSSSPNSNMS DWSEGISSPP 2450
TSMQSQIGHM PEQFK 2465
Length:2,465
Mass (Da):267,589
Last modified:January 9, 2007 - v1
Checksum:iA58F9D8A2D519F7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY805407 mRNA. Translation: AAX19695.1.
RefSeqiNP_571377.2. NM_131302.2.
UniGeneiDr.75825.

Genome annotation databases

GeneIDi794892.
KEGGidre:794892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY805407 mRNA. Translation: AAX19695.1 .
RefSeqi NP_571377.2. NM_131302.2.
UniGenei Dr.75825.

3D structure databases

ProteinModelPortali A0PGH6.
SMRi A0PGH6. Positions 431-546, 1860-2100.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 794892.
KEGGi dre:794892.

Organism-specific databases

CTDi 794892.
ZFINi ZDB-GENE-990415-183. notch1b.

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000234369.
HOVERGENi HBG052650.
InParanoidi A0PGH6.
KOi K02599.
PhylomeDBi A0PGH6.

Miscellaneous databases

NextBioi 20932028.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR022362. Notch_1.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 20 hits.
PF07645. EGF_CA. 5 hits.
PF12661. hEGF. 1 hit.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view ]
PIRSFi PIRSF002279. Notch. 1 hit.
PRINTSi PR01452. LNOTCHREPEAT.
PR01984. NOTCH1.
SMARTi SM00248. ANK. 6 hits.
SM00181. EGF. 11 hits.
SM00179. EGF_CA. 24 hits.
SM00004. NL. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS00010. ASX_HYDROXYL. 23 hits.
PS00022. EGF_1. 32 hits.
PS01186. EGF_2. 25 hits.
PS50026. EGF_3. 35 hits.
PS01187. EGF_CA. 22 hits.
PS50258. LNR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and function of zebrafish notch1b gene."
    Qiu X., Jiang Y.J.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA0PGH6_DANRE
AccessioniPrimary (citable) accession number: A0PGH6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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