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A0PGH6

- A0PGH6_DANRE

UniProt

A0PGH6 - A0PGH6_DANRE

Protein
Submitted name:

Notch1b

Gene

notch1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: InterPro
    2. multicellular organismal development Source: InterPro
    3. Notch signaling pathway Source: InterPro
    4. regulation of developmental process Source: InterPro
    5. regulation of transcription, DNA-templated Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Notch1bImported
    Gene namesi
    Name:notch1bImported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

    Organism-specific databases

    ZFINiZDB-GENE-990415-183. notch1b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliA0PGH6.
    SMRiA0PGH6. Positions 431-546, 1860-2100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 6 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000234369.
    HOVERGENiHBG052650.
    InParanoidiA0PGH6.
    KOiK02599.
    PhylomeDBiA0PGH6.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR024600. DUF3454_notch.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR008297. Notch.
    IPR022362. Notch_1.
    IPR000800. Notch_dom.
    IPR010660. Notch_NOD_dom.
    IPR011656. Notch_NODP_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 2 hits.
    PF11936. DUF3454. 1 hit.
    PF00008. EGF. 20 hits.
    PF07645. EGF_CA. 5 hits.
    PF12661. hEGF. 1 hit.
    PF06816. NOD. 1 hit.
    PF07684. NODP. 1 hit.
    PF00066. Notch. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002279. Notch. 1 hit.
    PRINTSiPR01452. LNOTCHREPEAT.
    PR01984. NOTCH1.
    SMARTiSM00248. ANK. 6 hits.
    SM00181. EGF. 11 hits.
    SM00179. EGF_CA. 24 hits.
    SM00004. NL. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF57184. SSF57184. 5 hits.
    SSF90193. SSF90193. 3 hits.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS00010. ASX_HYDROXYL. 23 hits.
    PS00022. EGF_1. 32 hits.
    PS01186. EGF_2. 25 hits.
    PS50026. EGF_3. 35 hits.
    PS01187. EGF_CA. 22 hits.
    PS50258. LNR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0PGH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHLFFVKLIV VISLNTLTQG LECSEKCQNG GTCEPTADGR GECKCLDLYA     50
    GPACQFRNPC FQSPCRNGGV CRLITSANKV DFVCNCSLGY TDRLCLTPTN 100
    NVCLGAPCRN GGTCELTSIH NYRCKCPPGW SGKTCQQADP CASNPCANGG 150
    QCSPFDSDFL CHCTPYFSGQ TCKQDVNECA QIPSPCKNGG VCENGVGTYH 200
    CNCPAEYTGK HCESLYQPCN PSPCLHGGTC VQKGETSYEC SCLPGRQEFV 250
    LIMRKCLNDY FLMLVFIGFS GQNCEENIDD CPDHRCLNGG TCVDGVNTYN 300
    CQCKPEWTGQ FCTEDVNECD LMPNSCQNGG TCLNTQGGYN CVCVNGWTGD 350
    DCSENIDDCA DAACHTGATC HDRVASFLCE CPHGRTGLLC HLDDACISNP 400
    CQKGSNCDTN PVNGKAICTC PLGYVGPACD QDVDECSLGA NPCEHAGKCI 450
    NTKGSFQCKC LQGYVGARCE LDINECLSTP CQNDATCLDQ IGGFHCICMP 500
    GYEGVFCQIN TDECASMPCL NNGKCIDKIN NYQCECPTGF SGSQCQFDID 550
    ECASTPCKNG AKCMDGPNMY TCQCTEGYTG QHCETDVDEC LSNPCHYGTC 600
    KDGLASFTCV CRAGFMGRLC EININECLSQ PCQNGGTCQD RENAYLCVCP 650
    KGTAGANCEI NLDDCQSNPC DFGRCIDKIN GYECACEPGY TGKMCNVNID 700
    ECAINPCHNG GTCVDGVNGF TCLCREGYHD TTCQSQLNEC LSNPCIHGHC 750
    EDKVNGYNCI CDSGWSGVNC DINNNECESN PCMNGGTCKD MTSGYVCTCR 800
    AGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGQTCEVDI 850
    NECVKNPCRN DAICQNSIGS YKCSCKAGYT GRNCETDIDD CKPNPCSNGG 900
    FCKDAVNAFT CTCLPGFRGG RCEEDINECE SNPCKNGANC TDCVNSYTCT 950
    CPPGFSGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP KGFTGNYCQH 1000
    DINECDSRPC MNGGTCQDSY GTYKCTCPQG YHGLNCQELV NWCKPSPCKN 1050
    GGICRQSGTR YSCQCQTGWT GLYCDVPSVS CEVAAKQQGV DVVRLCRNSG 1100
    QCLDAGNTHY CHCQAGYTGS YCEEQVDECI PNPCQNGATC TDYLGGYSCE 1150
    CVPGYHGVNC SDEINECLSQ PCQNGGTCID LINTYKCSCP RGTQGVHCEI 1200
    NIDDCTPFTD PITHEPKCFN QGRCVDRVGG YHCICPPGYV GERCEGDVNE 1250
    CLSNPCGTHS CIQLKNNYRC ECRTGYTGQH CDKVFDGCKG KPCRNGGTCA 1300
    VASNTPHGFI CKCPPGFTGS TCEYDAHACG SLQCKNGGTC VSGHKSPKCL 1350
    CTPAFTGPEC QDPSGGHCTT NPCYNGGTCE YITEEPYYHC ICPTNFNGLF 1400
    CHILDWSFPG GTGQDITPAP KVSVSCEIEQ CKVKKGNKIC DSACNNYACD 1450
    WDGGDCSLNF NDPWKNCSAA LQCWRYFNNG KCDEQCHNTG CLYDGFDCQR 1500
    VEAQCNPLYD QYCKDHFADG YCDQGCNNAE CEWDGLDCAN DTPEKLAAGL 1550
    LVVVVHIHPD QLRNNSFGFL RELSRVLHTN VVFRRDSKGQ EMIYPYYGNE 1600
    QELKKHNIKR SLDGWNDASS DVLSSMKNSI YNIVVEGGRK RRELEKIQVK 1650
    GSVVYLEIDN RQCYQQTSEC FQSANDAAAF LGALASSGSL KMPYVIEAVT 1700
    SEIDGPSPVE LYPVYVVLAG LALLAFVAIG MVASRKRRRE HGQLWFPEGF 1750
    KTSEPSKKKR REPVGEDSVG LRPLKNCSDI SLMDDNQNEW GEEEQSDSKR 1800
    FRSEEQAMLD LDDQPDHRQW TQQHLDAADL RIPSIAPTPP QGEIENDCMD 1850
    VNARGPDGFT PLMIASCSGG GLETGNSEEE EDASANVIND FIYQGANLHN 1900
    QTDRTGETAL HLAARYARSD AAKRLLEASA DANIQDNMGR TPLHAAVAAD 1950
    AQGVFQILIR NRATDLDARM HDGTTPLILA ARLAVEGMVE ELINCHADVN 2000
    AIDDFGKSAL HWAAAVNNVD AAMVLLKNGA NKDMQNNKEE TPLFLAAREG 2050
    SYETAKVLLE HFANREITDH MDRLPRDIAQ DRMHHDIVRL IDEYNLVRSP 2100
    PMHSAPLCTT LSPPLCSPNG FMGNMKPSVQ SKKPRKPSTK GIGCKDGKDM 2150
    KVKKKKAQDG KGNLLDSSAV LSPVDSLESP HGYISDIASP PQMTSPFQQS 2200
    PSMSLNQLQG MSDNHMGVSH LGIGNNQDLS HIQFDPLPPR LTHLPVAGSN 2250
    GSNVMNGQCE WLERMHGSMA PQNQFTAMRN ASGQANLHQS GLMTSHHNGR 2300
    PATLSQMMNY QSMQNTHLMQ QMQQSMQPRP QQTGVQLQSQ SQNFIGGDLG 2350
    GPELQQSAGN SMSIHTIIPQ ETQLLNPSSL GSSMAGTQFL TPPSQHSYTP 2400
    ALDANTPNHQ LQVPDHHPFL TPSPGSPDQW SSSSPNSNMS DWSEGISSPP 2450
    TSMQSQIGHM PEQFK 2465
    Length:2,465
    Mass (Da):267,589
    Last modified:January 9, 2007 - v1
    Checksum:iA58F9D8A2D519F7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY805407 mRNA. Translation: AAX19695.1.
    RefSeqiNP_571377.2. NM_131302.2.
    UniGeneiDr.75825.

    Genome annotation databases

    GeneIDi794892.
    KEGGidre:794892.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY805407 mRNA. Translation: AAX19695.1 .
    RefSeqi NP_571377.2. NM_131302.2.
    UniGenei Dr.75825.

    3D structure databases

    ProteinModelPortali A0PGH6.
    SMRi A0PGH6. Positions 431-546, 1860-2100.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 794892.
    KEGGi dre:794892.

    Organism-specific databases

    CTDi 794892.
    ZFINi ZDB-GENE-990415-183. notch1b.

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000234369.
    HOVERGENi HBG052650.
    InParanoidi A0PGH6.
    KOi K02599.
    PhylomeDBi A0PGH6.

    Miscellaneous databases

    NextBioi 20932028.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR024600. DUF3454_notch.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR008297. Notch.
    IPR022362. Notch_1.
    IPR000800. Notch_dom.
    IPR010660. Notch_NOD_dom.
    IPR011656. Notch_NODP_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 2 hits.
    PF11936. DUF3454. 1 hit.
    PF00008. EGF. 20 hits.
    PF07645. EGF_CA. 5 hits.
    PF12661. hEGF. 1 hit.
    PF06816. NOD. 1 hit.
    PF07684. NODP. 1 hit.
    PF00066. Notch. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002279. Notch. 1 hit.
    PRINTSi PR01452. LNOTCHREPEAT.
    PR01984. NOTCH1.
    SMARTi SM00248. ANK. 6 hits.
    SM00181. EGF. 11 hits.
    SM00179. EGF_CA. 24 hits.
    SM00004. NL. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF57184. SSF57184. 5 hits.
    SSF90193. SSF90193. 3 hits.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    PS00010. ASX_HYDROXYL. 23 hits.
    PS00022. EGF_1. 32 hits.
    PS01186. EGF_2. 25 hits.
    PS50026. EGF_3. 35 hits.
    PS01187. EGF_CA. 22 hits.
    PS50258. LNR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and function of zebrafish notch1b gene."
      Qiu X., Jiang Y.J.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA0PGH6_DANRE
    AccessioniPrimary (citable) accession number: A0PGH6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)