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A0PGH6

- A0PGH6_DANRE

UniProt

A0PGH6 - A0PGH6_DANRE

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Protein
Submitted name:

Notch1b

Gene

notch1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. receptor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: InterPro
  2. multicellular organismal development Source: InterPro
  3. Notch signaling pathway Source: InterPro
  4. regulation of developmental process Source: InterPro
  5. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Notch1bImported
Gene namesi
Name:notch1bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-183. notch1b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA0PGH6.
SMRiA0PGH6. Positions 431-546, 1860-2100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000234369.
HOVERGENiHBG052650.
KOiK02599.
PhylomeDBiA0PGH6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR022362. Notch_1.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 20 hits.
PF07645. EGF_CA. 5 hits.
PF12661. hEGF. 1 hit.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PIRSFiPIRSF002279. Notch. 1 hit.
PRINTSiPR01452. LNOTCHREPEAT.
PR01984. NOTCH1.
SMARTiSM00248. ANK. 6 hits.
SM00181. EGF. 11 hits.
SM00179. EGF_CA. 24 hits.
SM00004. NL. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS00010. ASX_HYDROXYL. 23 hits.
PS00022. EGF_1. 32 hits.
PS01186. EGF_2. 25 hits.
PS50026. EGF_3. 35 hits.
PS01187. EGF_CA. 22 hits.
PS50258. LNR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0PGH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHLFFVKLIV VISLNTLTQG LECSEKCQNG GTCEPTADGR GECKCLDLYA
60 70 80 90 100
GPACQFRNPC FQSPCRNGGV CRLITSANKV DFVCNCSLGY TDRLCLTPTN
110 120 130 140 150
NVCLGAPCRN GGTCELTSIH NYRCKCPPGW SGKTCQQADP CASNPCANGG
160 170 180 190 200
QCSPFDSDFL CHCTPYFSGQ TCKQDVNECA QIPSPCKNGG VCENGVGTYH
210 220 230 240 250
CNCPAEYTGK HCESLYQPCN PSPCLHGGTC VQKGETSYEC SCLPGRQEFV
260 270 280 290 300
LIMRKCLNDY FLMLVFIGFS GQNCEENIDD CPDHRCLNGG TCVDGVNTYN
310 320 330 340 350
CQCKPEWTGQ FCTEDVNECD LMPNSCQNGG TCLNTQGGYN CVCVNGWTGD
360 370 380 390 400
DCSENIDDCA DAACHTGATC HDRVASFLCE CPHGRTGLLC HLDDACISNP
410 420 430 440 450
CQKGSNCDTN PVNGKAICTC PLGYVGPACD QDVDECSLGA NPCEHAGKCI
460 470 480 490 500
NTKGSFQCKC LQGYVGARCE LDINECLSTP CQNDATCLDQ IGGFHCICMP
510 520 530 540 550
GYEGVFCQIN TDECASMPCL NNGKCIDKIN NYQCECPTGF SGSQCQFDID
560 570 580 590 600
ECASTPCKNG AKCMDGPNMY TCQCTEGYTG QHCETDVDEC LSNPCHYGTC
610 620 630 640 650
KDGLASFTCV CRAGFMGRLC EININECLSQ PCQNGGTCQD RENAYLCVCP
660 670 680 690 700
KGTAGANCEI NLDDCQSNPC DFGRCIDKIN GYECACEPGY TGKMCNVNID
710 720 730 740 750
ECAINPCHNG GTCVDGVNGF TCLCREGYHD TTCQSQLNEC LSNPCIHGHC
760 770 780 790 800
EDKVNGYNCI CDSGWSGVNC DINNNECESN PCMNGGTCKD MTSGYVCTCR
810 820 830 840 850
AGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGQTCEVDI
860 870 880 890 900
NECVKNPCRN DAICQNSIGS YKCSCKAGYT GRNCETDIDD CKPNPCSNGG
910 920 930 940 950
FCKDAVNAFT CTCLPGFRGG RCEEDINECE SNPCKNGANC TDCVNSYTCT
960 970 980 990 1000
CPPGFSGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP KGFTGNYCQH
1010 1020 1030 1040 1050
DINECDSRPC MNGGTCQDSY GTYKCTCPQG YHGLNCQELV NWCKPSPCKN
1060 1070 1080 1090 1100
GGICRQSGTR YSCQCQTGWT GLYCDVPSVS CEVAAKQQGV DVVRLCRNSG
1110 1120 1130 1140 1150
QCLDAGNTHY CHCQAGYTGS YCEEQVDECI PNPCQNGATC TDYLGGYSCE
1160 1170 1180 1190 1200
CVPGYHGVNC SDEINECLSQ PCQNGGTCID LINTYKCSCP RGTQGVHCEI
1210 1220 1230 1240 1250
NIDDCTPFTD PITHEPKCFN QGRCVDRVGG YHCICPPGYV GERCEGDVNE
1260 1270 1280 1290 1300
CLSNPCGTHS CIQLKNNYRC ECRTGYTGQH CDKVFDGCKG KPCRNGGTCA
1310 1320 1330 1340 1350
VASNTPHGFI CKCPPGFTGS TCEYDAHACG SLQCKNGGTC VSGHKSPKCL
1360 1370 1380 1390 1400
CTPAFTGPEC QDPSGGHCTT NPCYNGGTCE YITEEPYYHC ICPTNFNGLF
1410 1420 1430 1440 1450
CHILDWSFPG GTGQDITPAP KVSVSCEIEQ CKVKKGNKIC DSACNNYACD
1460 1470 1480 1490 1500
WDGGDCSLNF NDPWKNCSAA LQCWRYFNNG KCDEQCHNTG CLYDGFDCQR
1510 1520 1530 1540 1550
VEAQCNPLYD QYCKDHFADG YCDQGCNNAE CEWDGLDCAN DTPEKLAAGL
1560 1570 1580 1590 1600
LVVVVHIHPD QLRNNSFGFL RELSRVLHTN VVFRRDSKGQ EMIYPYYGNE
1610 1620 1630 1640 1650
QELKKHNIKR SLDGWNDASS DVLSSMKNSI YNIVVEGGRK RRELEKIQVK
1660 1670 1680 1690 1700
GSVVYLEIDN RQCYQQTSEC FQSANDAAAF LGALASSGSL KMPYVIEAVT
1710 1720 1730 1740 1750
SEIDGPSPVE LYPVYVVLAG LALLAFVAIG MVASRKRRRE HGQLWFPEGF
1760 1770 1780 1790 1800
KTSEPSKKKR REPVGEDSVG LRPLKNCSDI SLMDDNQNEW GEEEQSDSKR
1810 1820 1830 1840 1850
FRSEEQAMLD LDDQPDHRQW TQQHLDAADL RIPSIAPTPP QGEIENDCMD
1860 1870 1880 1890 1900
VNARGPDGFT PLMIASCSGG GLETGNSEEE EDASANVIND FIYQGANLHN
1910 1920 1930 1940 1950
QTDRTGETAL HLAARYARSD AAKRLLEASA DANIQDNMGR TPLHAAVAAD
1960 1970 1980 1990 2000
AQGVFQILIR NRATDLDARM HDGTTPLILA ARLAVEGMVE ELINCHADVN
2010 2020 2030 2040 2050
AIDDFGKSAL HWAAAVNNVD AAMVLLKNGA NKDMQNNKEE TPLFLAAREG
2060 2070 2080 2090 2100
SYETAKVLLE HFANREITDH MDRLPRDIAQ DRMHHDIVRL IDEYNLVRSP
2110 2120 2130 2140 2150
PMHSAPLCTT LSPPLCSPNG FMGNMKPSVQ SKKPRKPSTK GIGCKDGKDM
2160 2170 2180 2190 2200
KVKKKKAQDG KGNLLDSSAV LSPVDSLESP HGYISDIASP PQMTSPFQQS
2210 2220 2230 2240 2250
PSMSLNQLQG MSDNHMGVSH LGIGNNQDLS HIQFDPLPPR LTHLPVAGSN
2260 2270 2280 2290 2300
GSNVMNGQCE WLERMHGSMA PQNQFTAMRN ASGQANLHQS GLMTSHHNGR
2310 2320 2330 2340 2350
PATLSQMMNY QSMQNTHLMQ QMQQSMQPRP QQTGVQLQSQ SQNFIGGDLG
2360 2370 2380 2390 2400
GPELQQSAGN SMSIHTIIPQ ETQLLNPSSL GSSMAGTQFL TPPSQHSYTP
2410 2420 2430 2440 2450
ALDANTPNHQ LQVPDHHPFL TPSPGSPDQW SSSSPNSNMS DWSEGISSPP
2460
TSMQSQIGHM PEQFK
Length:2,465
Mass (Da):267,589
Last modified:January 9, 2007 - v1
Checksum:iA58F9D8A2D519F7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY805407 mRNA. Translation: AAX19695.1.
RefSeqiNP_571377.2. NM_131302.2.
UniGeneiDr.75825.

Genome annotation databases

GeneIDi794892.
KEGGidre:794892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY805407 mRNA. Translation: AAX19695.1 .
RefSeqi NP_571377.2. NM_131302.2.
UniGenei Dr.75825.

3D structure databases

ProteinModelPortali A0PGH6.
SMRi A0PGH6. Positions 431-546, 1860-2100.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 794892.
KEGGi dre:794892.

Organism-specific databases

CTDi 794892.
ZFINi ZDB-GENE-990415-183. notch1b.

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000234369.
HOVERGENi HBG052650.
KOi K02599.
PhylomeDBi A0PGH6.

Miscellaneous databases

NextBioi 20932028.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR024600. DUF3454_notch.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR008297. Notch.
IPR022362. Notch_1.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 2 hits.
PF11936. DUF3454. 1 hit.
PF00008. EGF. 20 hits.
PF07645. EGF_CA. 5 hits.
PF12661. hEGF. 1 hit.
PF06816. NOD. 1 hit.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view ]
PIRSFi PIRSF002279. Notch. 1 hit.
PRINTSi PR01452. LNOTCHREPEAT.
PR01984. NOTCH1.
SMARTi SM00248. ANK. 6 hits.
SM00181. EGF. 11 hits.
SM00179. EGF_CA. 24 hits.
SM00004. NL. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 3 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS00010. ASX_HYDROXYL. 23 hits.
PS00022. EGF_1. 32 hits.
PS01186. EGF_2. 25 hits.
PS50026. EGF_3. 35 hits.
PS01187. EGF_CA. 22 hits.
PS50258. LNR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and function of zebrafish notch1b gene."
    Qiu X., Jiang Y.J.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA0PGH6_DANRE
AccessioniPrimary (citable) accession number: A0PGH6
Entry historyi
Integrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)