Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A0PG75

- PLS5_HUMAN

UniProt

A0PG75 - PLS5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phospholipid scramblase family member 5

Gene

PLSCR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase family member 5
Gene namesi
Name:PLSCR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19952. PLSCR5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Phospholipid scramblase family member 5PRO_0000293720Add
BLAST

Proteomic databases

PaxDbiA0PG75.
PRIDEiA0PG75.

Expressioni

Gene expression databases

BgeeiA0PG75.
CleanExiHS_PLSCR5.
GenevestigatoriA0PG75.

Organism-specific databases

HPAiHPA047249.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000390111.

Structurei

3D structure databases

ProteinModelPortaliA0PG75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4545Proline-rich domain (PRD)By similarityAdd
BLAST

Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Phylogenomic databases

eggNOGiNOG303393.
GeneTreeiENSGT00390000002884.
HOGENOMiHOG000237356.
HOVERGENiHBG019157.
InParanoidiA0PG75.
OMAiIQNANKE.
OrthoDBiEOG77T14X.
PhylomeDBiA0PG75.
TreeFamiTF314939.

Family and domain databases

InterProiIPR005552. Scramblase.
IPR025659. Tubby_C-like.
[Graphical view]
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiPF03803. Scramblase. 1 hit.
[Graphical view]
SUPFAMiSSF54518. SSF54518. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A0PG75-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP
60 70 80 90 100
TVSLPPGLEY LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF
110 120 130 140 150
AVEESICFNR TFCSTLRSCT LRITDNSGRE VITVNRPLRC NSCWCPCYLQ
160 170 180 190 200
ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN ANKEDILKIV GPCVTCGCFG
210 220 230 240 250
DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV PADLDVTVKA
260 270
AMIGACFLFD FMFFEHSLAG L
Length:271
Mass (Da):30,027
Last modified:November 3, 2009 - v2
Checksum:i69CBE4A4E2A6DB54
GO
Isoform 2 (identifier: A0PG75-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-63: Missing.

Note: No experimental confirmation available.

Show »
Length:259
Mass (Da):28,742
Checksum:iA94BEF017B330619
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821T → A in AAR99737. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101R → S.
Corresponds to variant rs12107687 [ dbSNP | Ensembl ].
VAR_057700

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 6312Missing in isoform 2. 1 PublicationVSP_054160Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY436642 mRNA. Translation: AAR99737.1.
AC116544 Genomic DNA. No translation available.
BC157886 mRNA. Translation: AAI57887.1.
BC171917 mRNA. Translation: AAI71917.1.
CCDSiCCDS46931.1. [A0PG75-1]
RefSeqiNP_001078889.1. NM_001085420.1. [A0PG75-1]
XP_005247497.1. XM_005247440.2. [A0PG75-2]
UniGeneiHs.254692.

Genome annotation databases

EnsembliENST00000443512; ENSP00000390111; ENSG00000231213. [A0PG75-1]
ENST00000482567; ENSP00000418626; ENSG00000231213. [A0PG75-2]
ENST00000492200; ENSP00000417184; ENSG00000231213. [A0PG75-1]
GeneIDi389158.
KEGGihsa:389158.
UCSCiuc010hvb.3. human.
uc010hvc.3. human. [A0PG75-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY436642 mRNA. Translation: AAR99737.1 .
AC116544 Genomic DNA. No translation available.
BC157886 mRNA. Translation: AAI57887.1 .
BC171917 mRNA. Translation: AAI71917.1 .
CCDSi CCDS46931.1. [A0PG75-1 ]
RefSeqi NP_001078889.1. NM_001085420.1. [A0PG75-1 ]
XP_005247497.1. XM_005247440.2. [A0PG75-2 ]
UniGenei Hs.254692.

3D structure databases

ProteinModelPortali A0PG75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000390111.

Proteomic databases

PaxDbi A0PG75.
PRIDEi A0PG75.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000443512 ; ENSP00000390111 ; ENSG00000231213 . [A0PG75-1 ]
ENST00000482567 ; ENSP00000418626 ; ENSG00000231213 . [A0PG75-2 ]
ENST00000492200 ; ENSP00000417184 ; ENSG00000231213 . [A0PG75-1 ]
GeneIDi 389158.
KEGGi hsa:389158.
UCSCi uc010hvb.3. human.
uc010hvc.3. human. [A0PG75-1 ]

Organism-specific databases

CTDi 389158.
GeneCardsi GC03M146294.
HGNCi HGNC:19952. PLSCR5.
HPAi HPA047249.
neXtProti NX_A0PG75.
PharmGKBi PA134902268.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303393.
GeneTreei ENSGT00390000002884.
HOGENOMi HOG000237356.
HOVERGENi HBG019157.
InParanoidi A0PG75.
OMAi IQNANKE.
OrthoDBi EOG77T14X.
PhylomeDBi A0PG75.
TreeFami TF314939.

Miscellaneous databases

GeneWikii PLSCR5.
GenomeRNAii 389158.
NextBioi 102648.
PROi A0PG75.

Gene expression databases

Bgeei A0PG75.
CleanExi HS_PLSCR5.
Genevestigatori A0PG75.

Family and domain databases

InterProi IPR005552. Scramblase.
IPR025659. Tubby_C-like.
[Graphical view ]
PANTHERi PTHR23248. PTHR23248. 1 hit.
Pfami PF03803. Scramblase. 1 hit.
[Graphical view ]
SUPFAMi SSF54518. SSF54518. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel putative scramblase."
    Li X., Xie Y., Mao Y.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiPLS5_HUMAN
AccessioniPrimary (citable) accession number: A0PG75
Secondary accession number(s): B2RXK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3