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Protein

Phospholipid scramblase family member 5

Gene

PLSCR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase family member 5
Gene namesi
Name:PLSCR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000231213.6.
HGNCiHGNC:19952. PLSCR5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000231213.
PharmGKBiPA134902268.

Polymorphism and mutation databases

BioMutaiPLSCR5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002937201 – 271Phospholipid scramblase family member 5Add BLAST271

Proteomic databases

PaxDbiA0PG75.
PRIDEiA0PG75.

PTM databases

PhosphoSitePlusiA0PG75.

Expressioni

Gene expression databases

BgeeiENSG00000231213.
CleanExiHS_PLSCR5.

Organism-specific databases

HPAiHPA047249.

Interactioni

Protein-protein interaction databases

BioGridi133006. 4 interactors.
STRINGi9606.ENSP00000390111.

Structurei

3D structure databases

ProteinModelPortaliA0PG75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Proline-rich domain (PRD)By similarityAdd BLAST45

Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Phylogenomic databases

eggNOGiKOG0621. Eukaryota.
ENOG410XSYS. LUCA.
GeneTreeiENSGT00390000002884.
HOGENOMiHOG000237356.
HOVERGENiHBG019157.
InParanoidiA0PG75.
OMAiGCFGDVD.
OrthoDBiEOG091G0CUL.
PhylomeDBiA0PG75.
TreeFamiTF314939.

Family and domain databases

InterProiView protein in InterPro
IPR005552. Scramblase.
IPR025659. Tubby_C-like.
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiView protein in Pfam
PF03803. Scramblase. 1 hit.
SUPFAMiSSF54518. SSF54518. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0PG75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP
60 70 80 90 100
TVSLPPGLEY LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF
110 120 130 140 150
AVEESICFNR TFCSTLRSCT LRITDNSGRE VITVNRPLRC NSCWCPCYLQ
160 170 180 190 200
ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN ANKEDILKIV GPCVTCGCFG
210 220 230 240 250
DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV PADLDVTVKA
260 270
AMIGACFLFD FMFFEHSLAG L
Length:271
Mass (Da):30,027
Last modified:November 3, 2009 - v2
Checksum:i69CBE4A4E2A6DB54
GO
Isoform 2 (identifier: A0PG75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-63: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):28,742
Checksum:iA94BEF017B330619
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82T → A in AAR99737 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057700110R → S. Corresponds to variant dbSNP:rs12107687Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05416052 – 63Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436642 mRNA. Translation: AAR99737.1.
AC116544 Genomic DNA. No translation available.
BC157886 mRNA. Translation: AAI57887.1.
BC171917 mRNA. Translation: AAI71917.1.
CCDSiCCDS46931.1. [A0PG75-1]
CCDS82853.1. [A0PG75-2]
RefSeqiNP_001078889.1. NM_001085420.1. [A0PG75-1]
NP_001308174.1. NM_001321245.1. [A0PG75-2]
UniGeneiHs.254692.

Genome annotation databases

EnsembliENST00000443512; ENSP00000390111; ENSG00000231213. [A0PG75-1]
ENST00000482567; ENSP00000418626; ENSG00000231213. [A0PG75-2]
ENST00000492200; ENSP00000417184; ENSG00000231213. [A0PG75-1]
GeneIDi389158.
KEGGihsa:389158.
UCSCiuc010hvb.4. human. [A0PG75-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPLS5_HUMAN
AccessioniPrimary (citable) accession number: A0PG75
Secondary accession number(s): B2RXK5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 3, 2009
Last modified: September 27, 2017
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families