Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A0PG75

- PLS5_HUMAN

UniProt

A0PG75 - PLS5_HUMAN

Protein

Phospholipid scramblase family member 5

Gene

PLSCR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipid scramblase family member 5
    Gene namesi
    Name:PLSCR5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19952. PLSCR5.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134902268.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Phospholipid scramblase family member 5PRO_0000293720Add
    BLAST

    Proteomic databases

    PaxDbiA0PG75.
    PRIDEiA0PG75.

    Expressioni

    Gene expression databases

    BgeeiA0PG75.
    CleanExiHS_PLSCR5.
    GenevestigatoriA0PG75.

    Organism-specific databases

    HPAiHPA047249.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000390111.

    Structurei

    3D structure databases

    ProteinModelPortaliA0PG75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4545Proline-rich domain (PRD)By similarityAdd
    BLAST

    Domaini

    The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

    Sequence similaritiesi

    Belongs to the phospholipid scramblase family.Curated

    Phylogenomic databases

    eggNOGiNOG303393.
    HOGENOMiHOG000237356.
    HOVERGENiHBG019157.
    OMAiIQNANKE.
    OrthoDBiEOG77T14X.
    PhylomeDBiA0PG75.
    TreeFamiTF314939.

    Family and domain databases

    InterProiIPR005552. Scramblase.
    IPR025659. Tubby_C-like.
    [Graphical view]
    PANTHERiPTHR23248. PTHR23248. 1 hit.
    PfamiPF03803. Scramblase. 1 hit.
    [Graphical view]
    SUPFAMiSSF54518. SSF54518. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A0PG75-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP    50
    TVSLPPGLEY LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF 100
    AVEESICFNR TFCSTLRSCT LRITDNSGRE VITVNRPLRC NSCWCPCYLQ 150
    ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN ANKEDILKIV GPCVTCGCFG 200
    DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV PADLDVTVKA 250
    AMIGACFLFD FMFFEHSLAG L 271
    Length:271
    Mass (Da):30,027
    Last modified:November 3, 2009 - v2
    Checksum:i69CBE4A4E2A6DB54
    GO
    Isoform 2 (identifier: A0PG75-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-63: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:259
    Mass (Da):28,742
    Checksum:iA94BEF017B330619
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821T → A in AAR99737. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101R → S.
    Corresponds to variant rs12107687 [ dbSNP | Ensembl ].
    VAR_057700

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 6312Missing in isoform 2. 1 PublicationVSP_054160Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY436642 mRNA. Translation: AAR99737.1.
    AC116544 Genomic DNA. No translation available.
    BC157886 mRNA. Translation: AAI57887.1.
    BC171917 mRNA. Translation: AAI71917.1.
    CCDSiCCDS46931.1. [A0PG75-1]
    RefSeqiNP_001078889.1. NM_001085420.1. [A0PG75-1]
    XP_005247497.1. XM_005247440.2. [A0PG75-2]
    UniGeneiHs.254692.

    Genome annotation databases

    EnsembliENST00000443512; ENSP00000390111; ENSG00000231213. [A0PG75-1]
    ENST00000482567; ENSP00000418626; ENSG00000231213. [A0PG75-2]
    ENST00000492200; ENSP00000417184; ENSG00000231213. [A0PG75-1]
    GeneIDi389158.
    KEGGihsa:389158.
    UCSCiuc010hvc.3. human. [A0PG75-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY436642 mRNA. Translation: AAR99737.1 .
    AC116544 Genomic DNA. No translation available.
    BC157886 mRNA. Translation: AAI57887.1 .
    BC171917 mRNA. Translation: AAI71917.1 .
    CCDSi CCDS46931.1. [A0PG75-1 ]
    RefSeqi NP_001078889.1. NM_001085420.1. [A0PG75-1 ]
    XP_005247497.1. XM_005247440.2. [A0PG75-2 ]
    UniGenei Hs.254692.

    3D structure databases

    ProteinModelPortali A0PG75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000390111.

    Proteomic databases

    PaxDbi A0PG75.
    PRIDEi A0PG75.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000443512 ; ENSP00000390111 ; ENSG00000231213 . [A0PG75-1 ]
    ENST00000482567 ; ENSP00000418626 ; ENSG00000231213 . [A0PG75-2 ]
    ENST00000492200 ; ENSP00000417184 ; ENSG00000231213 . [A0PG75-1 ]
    GeneIDi 389158.
    KEGGi hsa:389158.
    UCSCi uc010hvc.3. human. [A0PG75-1 ]

    Organism-specific databases

    CTDi 389158.
    GeneCardsi GC03M146294.
    HGNCi HGNC:19952. PLSCR5.
    HPAi HPA047249.
    neXtProti NX_A0PG75.
    PharmGKBi PA134902268.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303393.
    HOGENOMi HOG000237356.
    HOVERGENi HBG019157.
    OMAi IQNANKE.
    OrthoDBi EOG77T14X.
    PhylomeDBi A0PG75.
    TreeFami TF314939.

    Miscellaneous databases

    GeneWikii PLSCR5.
    GenomeRNAii 389158.
    NextBioi 102648.
    PROi A0PG75.

    Gene expression databases

    Bgeei A0PG75.
    CleanExi HS_PLSCR5.
    Genevestigatori A0PG75.

    Family and domain databases

    InterProi IPR005552. Scramblase.
    IPR025659. Tubby_C-like.
    [Graphical view ]
    PANTHERi PTHR23248. PTHR23248. 1 hit.
    Pfami PF03803. Scramblase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54518. SSF54518. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel putative scramblase."
      Li X., Xie Y., Mao Y.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiPLS5_HUMAN
    AccessioniPrimary (citable) accession number: A0PG75
    Secondary accession number(s): B2RXK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3