A0PG75 (PLS5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipid scramblase family member 5

Gene names

Name:

PLSCR5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the phospholipid scramblase family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Phospholipid scramblase family member 5		PRO_0000293720
Natural variations
	Natural variant	110	1	R → S. Corresponds to variant rs12107687 [ dbSNP | Ensembl ].		VAR_057700
Experimental info
	Sequence conflict	82	1	T → A in AAR99737. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	A0PG75 [UniParc]. Last modified November 3, 2009. Version 2. Checksum: 69CBE4A4E2A6DB54	FASTA	271	30,027
	10 20 30 40 50 60 MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP TVSLPPGLEY 70 80 90 100 110 120 LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF AVEESICFNR TFCSTLRSCT 130 140 150 160 170 180 LRITDNSGRE VITVNRPLRC NSCWCPCYLQ ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN 190 200 210 220 230 240 ANKEDILKIV GPCVTCGCFG DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV 250 260 270 PADLDVTVKA AMIGACFLFD FMFFEHSLAG L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel putative scramblase." Li X., Xie Y., Mao Y. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY436642 mRNA. Translation: AAR99737.1. AC116544 Genomic DNA. No translation available.
IPI	IPI00374235.
RefSeq	NP_001078889.1. NM_001085420.1.
UniGene	Hs.254692.
3D structure databases
ProteinModelPortal	A0PG75.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000390111.
Proteomic databases
PaxDb	A0PG75.
PRIDE	A0PG75.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000443512; ENSP00000390111; ENSG00000231213. ENST00000492200; ENSP00000417184; ENSG00000231213.
GeneID	389158.
KEGG	hsa:389158.
UCSC	uc010hvc.3. human.
Organism-specific databases
CTD	389158.
GeneCards	GC03M146294.
HGNC	HGNC:19952. PLSCR5.
HPA	HPA047249.
neXtProt	NX_A0PG75.
PharmGKB	PA134902268.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG303393.
HOGENOM	HOG000237356.
HOVERGEN	HBG019157.
OMA	IQNANKE.
OrthoDB	EOG45MN60.
Gene expression databases
ArrayExpress	A0PG75.
Bgee	A0PG75.
CleanEx	HS_PLSCR5.
Genevestigator	A0PG75.
Family and domain databases
InterPro	IPR005552. Scramblase. IPR025659. Tubby_C-like. [Graphical view]
PANTHER	PTHR23248. PTHR23248. 1 hit.
Pfam	PF03803. Scramblase. 1 hit. [Graphical view]
SUPFAM	SSF54518. Tubby_C. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	389158.
NextBio	102648.

Entry information

Entry name

PLS5_HUMAN

Accession

Primary (citable) accession number: A0PG75

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	November 3, 2009
Last modified:	April 3, 2013
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.