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A0PG75 (PLS5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipid scramblase family member 5
Gene names
Name:PLSCR5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Domain

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity By similarity.

Sequence similarities

Belongs to the phospholipid scramblase family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A0PG75-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A0PG75-2)

The sequence of this isoform differs from the canonical sequence as follows:
     52-63: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Phospholipid scramblase family member 5
PRO_0000293720

Regions

Region1 – 4545Proline-rich domain (PRD) By similarity

Natural variations

Alternative sequence52 – 6312Missing in isoform 2.
VSP_054160
Natural variant1101R → S.
Corresponds to variant rs12107687 [ dbSNP | Ensembl ].
VAR_057700

Experimental info

Sequence conflict821T → A in AAR99737. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 3, 2009. Version 2.
Checksum: 69CBE4A4E2A6DB54

FASTA27130,027
        10         20         30         40         50         60 
MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP TVSLPPGLEY 

        70         80         90        100        110        120 
LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF AVEESICFNR TFCSTLRSCT 

       130        140        150        160        170        180 
LRITDNSGRE VITVNRPLRC NSCWCPCYLQ ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN 

       190        200        210        220        230        240 
ANKEDILKIV GPCVTCGCFG DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV 

       250        260        270 
PADLDVTVKA AMIGACFLFD FMFFEHSLAG L 

« Hide

Isoform 2 [UniParc].

Checksum: A94BEF017B330619
Show »

FASTA25928,742

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel putative scramblase."
Li X., Xie Y., Mao Y.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY436642 mRNA. Translation: AAR99737.1.
AC116544 Genomic DNA. No translation available.
BC157886 mRNA. Translation: AAI57887.1.
BC171917 mRNA. Translation: AAI71917.1.
CCDSCCDS46931.1.
RefSeqNP_001078889.1. NM_001085420.1. [A0PG75-1]
XP_005247497.1. XM_005247440.2. [A0PG75-2]
UniGeneHs.254692.

3D structure databases

ProteinModelPortalA0PG75.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000390111.

Proteomic databases

PaxDbA0PG75.
PRIDEA0PG75.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000443512; ENSP00000390111; ENSG00000231213.
ENST00000482567; ENSP00000418626; ENSG00000231213.
ENST00000492200; ENSP00000417184; ENSG00000231213.
GeneID389158.
KEGGhsa:389158.
UCSCuc010hvc.3. human. [A0PG75-1]

Organism-specific databases

CTD389158.
GeneCardsGC03M146294.
HGNCHGNC:19952. PLSCR5.
HPAHPA047249.
neXtProtNX_A0PG75.
PharmGKBPA134902268.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG303393.
HOGENOMHOG000237356.
HOVERGENHBG019157.
OMAIQNANKE.
OrthoDBEOG77T14X.
PhylomeDBA0PG75.
TreeFamTF314939.

Gene expression databases

BgeeA0PG75.
CleanExHS_PLSCR5.
GenevestigatorA0PG75.

Family and domain databases

InterProIPR005552. Scramblase.
IPR025659. Tubby_C-like.
[Graphical view]
PANTHERPTHR23248. PTHR23248. 1 hit.
PfamPF03803. Scramblase. 1 hit.
[Graphical view]
SUPFAMSSF54518. SSF54518. 1 hit.
ProtoNetSearch...

Other

GeneWikiPLSCR5.
GenomeRNAi389158.
NextBio102648.
PROA0PG75.

Entry information

Entry namePLS5_HUMAN
AccessionPrimary (citable) accession number: A0PG75
Secondary accession number(s): B2RXK5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 3, 2009
Last modified: July 9, 2014
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM