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Protein

Phospholipid scramblase family member 5

Gene

PLSCR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid scramblase family member 5
Gene namesi
Name:PLSCR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19952. PLSCR5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134902268.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Phospholipid scramblase family member 5PRO_0000293720Add
BLAST

Proteomic databases

PaxDbiA0PG75.
PRIDEiA0PG75.

Expressioni

Gene expression databases

BgeeiA0PG75.
CleanExiHS_PLSCR5.
GenevestigatoriA0PG75.

Organism-specific databases

HPAiHPA047249.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000390111.

Structurei

3D structure databases

ProteinModelPortaliA0PG75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4545Proline-rich domain (PRD)By similarityAdd
BLAST

Domaini

The N-terminal proline-rich domain (PRD) is required for phospholipid scramblase activity.By similarity

Sequence similaritiesi

Belongs to the phospholipid scramblase family.Curated

Phylogenomic databases

eggNOGiNOG303393.
GeneTreeiENSGT00390000002884.
HOGENOMiHOG000237356.
HOVERGENiHBG019157.
InParanoidiA0PG75.
OMAiIQNANKE.
OrthoDBiEOG77T14X.
PhylomeDBiA0PG75.
TreeFamiTF314939.

Family and domain databases

InterProiIPR005552. Scramblase.
IPR025659. Tubby_C-like.
[Graphical view]
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiPF03803. Scramblase. 1 hit.
[Graphical view]
SUPFAMiSSF54518. SSF54518. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A0PG75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKDAQNQR RGLPGFLPGA PDPDQSLPAS SNPGNQAWQL SLPLPSSFLP
60 70 80 90 100
TVSLPPGLEY LSQLDLIIIH QQVELLGMIL GTETSNKYEI KNSLGQRIYF
110 120 130 140 150
AVEESICFNR TFCSTLRSCT LRITDNSGRE VITVNRPLRC NSCWCPCYLQ
160 170 180 190 200
ELEIQAPPGT IVGYVTQKWD PFLPKFTIQN ANKEDILKIV GPCVTCGCFG
210 220 230 240 250
DVDFEVKTIN EKLTIGKISK YWSGFVNDVF TNADNFGIHV PADLDVTVKA
260 270
AMIGACFLFD FMFFEHSLAG L
Length:271
Mass (Da):30,027
Last modified:November 3, 2009 - v2
Checksum:i69CBE4A4E2A6DB54
GO
Isoform 2 (identifier: A0PG75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-63: Missing.

Note: No experimental confirmation available.

Show »
Length:259
Mass (Da):28,742
Checksum:iA94BEF017B330619
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821T → A in AAR99737 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101R → S.
Corresponds to variant rs12107687 [ dbSNP | Ensembl ].
VAR_057700

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 6312Missing in isoform 2. 1 PublicationVSP_054160Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436642 mRNA. Translation: AAR99737.1.
AC116544 Genomic DNA. No translation available.
BC157886 mRNA. Translation: AAI57887.1.
BC171917 mRNA. Translation: AAI71917.1.
CCDSiCCDS46931.1. [A0PG75-1]
RefSeqiNP_001078889.1. NM_001085420.1. [A0PG75-1]
XP_005247497.1. XM_005247440.2. [A0PG75-2]
UniGeneiHs.254692.

Genome annotation databases

EnsembliENST00000443512; ENSP00000390111; ENSG00000231213. [A0PG75-1]
ENST00000482567; ENSP00000418626; ENSG00000231213. [A0PG75-2]
ENST00000492200; ENSP00000417184; ENSG00000231213. [A0PG75-1]
GeneIDi389158.
KEGGihsa:389158.
UCSCiuc010hvb.3. human.
uc010hvc.3. human. [A0PG75-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY436642 mRNA. Translation: AAR99737.1.
AC116544 Genomic DNA. No translation available.
BC157886 mRNA. Translation: AAI57887.1.
BC171917 mRNA. Translation: AAI71917.1.
CCDSiCCDS46931.1. [A0PG75-1]
RefSeqiNP_001078889.1. NM_001085420.1. [A0PG75-1]
XP_005247497.1. XM_005247440.2. [A0PG75-2]
UniGeneiHs.254692.

3D structure databases

ProteinModelPortaliA0PG75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000390111.

Proteomic databases

PaxDbiA0PG75.
PRIDEiA0PG75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000443512; ENSP00000390111; ENSG00000231213. [A0PG75-1]
ENST00000482567; ENSP00000418626; ENSG00000231213. [A0PG75-2]
ENST00000492200; ENSP00000417184; ENSG00000231213. [A0PG75-1]
GeneIDi389158.
KEGGihsa:389158.
UCSCiuc010hvb.3. human.
uc010hvc.3. human. [A0PG75-1]

Organism-specific databases

CTDi389158.
GeneCardsiGC03M146294.
HGNCiHGNC:19952. PLSCR5.
HPAiHPA047249.
neXtProtiNX_A0PG75.
PharmGKBiPA134902268.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG303393.
GeneTreeiENSGT00390000002884.
HOGENOMiHOG000237356.
HOVERGENiHBG019157.
InParanoidiA0PG75.
OMAiIQNANKE.
OrthoDBiEOG77T14X.
PhylomeDBiA0PG75.
TreeFamiTF314939.

Miscellaneous databases

GeneWikiiPLSCR5.
GenomeRNAii389158.
NextBioi102648.
PROiA0PG75.

Gene expression databases

BgeeiA0PG75.
CleanExiHS_PLSCR5.
GenevestigatoriA0PG75.

Family and domain databases

InterProiIPR005552. Scramblase.
IPR025659. Tubby_C-like.
[Graphical view]
PANTHERiPTHR23248. PTHR23248. 1 hit.
PfamiPF03803. Scramblase. 1 hit.
[Graphical view]
SUPFAMiSSF54518. SSF54518. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel putative scramblase."
    Li X., Xie Y., Mao Y.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiPLS5_HUMAN
AccessioniPrimary (citable) accession number: A0PG75
Secondary accession number(s): B2RXK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 3, 2009
Last modified: January 7, 2015
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.