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Protein

Mitochondrial brown fat uncoupling protein 1

Gene

UCP1

Organism
Ochotona dauurica (Daurian pika)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.By similarity

Enzyme regulationi

Has no constitutive proton transporter activity and has to be activated by long-chain fatty acids/LCFAs. Inhibited by purine nucleotides. Both purine nucleotides and LCFAs bind the cytosolic side of the transporter and directly compete to activate or inhibit it. Activated by noradrenaline and reactive oxygen species.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial brown fat uncoupling protein 1Curated
Short name:
UCP 1Curated
Alternative name(s):
Solute carrier family 25 member 7By similarity
ThermogeninBy similarity
Gene namesi
Name:UCP11 Publication
Synonyms:SLC25A7By similarity
OrganismiOchotona dauurica (Daurian pika)
Taxonomic identifieri130827 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaOchotonidaeOchotona

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10Mitochondrial intermembraneBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini33 – 73Mitochondrial matrixBy similarityAdd BLAST41
Transmembranei74 – 96Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini97 – 115Mitochondrial intermembraneBy similarityAdd BLAST19
Transmembranei116 – 132Helical; Name=3Sequence analysisAdd BLAST17
Topological domaini133 – 177Mitochondrial matrixBy similarityAdd BLAST45
Transmembranei178 – 194Helical; Name=4Sequence analysisAdd BLAST17
Topological domaini195 – 211Mitochondrial intermembraneBy similarityAdd BLAST17
Transmembranei212 – 231Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini232 – 265Mitochondrial matrixBy similarityAdd BLAST34
Transmembranei266 – 288Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini289 – 306Mitochondrial intermembraneBy similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818511 – 306Mitochondrial brown fat uncoupling protein 1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253Cysteine sulfenic acid (-SOH)By similarity1

Post-translational modificationi

May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects.By similarity
May undergo ubiquitin-mediated proteasomal degradation.By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Most probably functions as a monomer. Binds one purine nucleotide per monomer. However, has also been suggested to function as a homodimer or a homotetramer. Tightly associates with cardiolipin in the mitochondrion inner membrane; may stabilize and regulate its activity.By similarity

Structurei

3D structure databases

ProteinModelPortaliA0PC02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 102Solcar 1Add BLAST92
Repeati110 – 200Solcar 2Add BLAST91
Repeati209 – 294Solcar 3Add BLAST86

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009528.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002030. Mit_uncoupling_UCP-like.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

A0PC02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGTTATDVA PTMGVKIFSA GVAACLADVI TFPLDTAKVR LQIQGECQTT
60 70 80 90 100
SGIRYKGVLG TITTLAKTEG PLKLYSGLPA GLQRQISFAS LRIGLYDTVQ
110 120 130 140 150
EFWGGEEATP SLRSKICAGL TTGGVAVFIG QPTEVVKVRL QAQSHLHGLK
160 170 180 190 200
PRYTGTYNAY RIIATTESLS TLWKGTTPNL LRNIIINCTE LVTYDLMKGA
210 220 230 240 250
LVRNDILADD VPCHLLSALI AGFCTTLLSS PVDVVKTRFI NSPQGQYTSV
260 270 280 290 300
PSCAMSMLTK EGPTAFFKGF APSFLRLASW NVIMFVCFEK LKRELMKSRQ

TVDCAT
Length:306
Mass (Da):33,105
Last modified:January 9, 2007 - v1
Checksum:i4DB66A4DC05E617B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB283043 mRNA. Translation: BAF37006.1.

Similar proteinsi

Entry informationi

Entry nameiUCP1_OCHDA
AccessioniPrimary (citable) accession number: A0PC02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 9, 2007
Last modified: November 22, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families