ID   A0PAB2_ONCMY            Unreviewed;       378 AA.
AC   A0PAB2;
DT   09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Alpha 2,8-polysialyltransferase IIa {ECO:0000313|EMBL:BAF37192.1};
GN   Name=ST8Sia IIa {ECO:0000313|EMBL:BAF37192.1};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022 {ECO:0000313|EMBL:BAF37192.1};
RN   [1] {ECO:0000313|EMBL:BAF37192.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary {ECO:0000313|EMBL:BAF37192.1};
RX   PubMed=17023684; DOI=10.1093/jb/mvj200;
RA   Asahina S., Sato C., Matsuno M., Matsuda T., Colley K., Kitajima K.;
RT   "Involvement of the alpha2,8-polysialyltransferases II/STX and IV/PST in
RT   the biosynthesis of polysialic acid chains on the O-linked glycoproteins in
RT   rainbow trout ovary.";
RL   J. Biochem. 140:687-701(2006).
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 29 family.
CC       {ECO:0000256|ARBA:ARBA00006003}.
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DR   EMBL; AB262976; BAF37192.1; -; mRNA.
DR   RefSeq; NP_001117712.1; NM_001124240.1.
DR   AlphaFoldDB; A0PAB2; -.
DR   CAZy; GT29; Glycosyltransferase Family 29.
DR   GeneID; 100135855; -.
DR   KEGG; omy:100135855; -.
DR   CTD; 8128; -.
DR   OrthoDB; 5348004at2759; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008373; F:sialyltransferase activity; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   Gene3D; 3.90.1480.20; Glycosyl transferase family 29; 1.
DR   InterPro; IPR001675; Glyco_trans_29.
DR   InterPro; IPR038578; GT29-like_sf.
DR   InterPro; IPR012163; Sialyl_trans.
DR   PANTHER; PTHR11987; ALPHA-2,8-SIALYLTRANSFERASE; 1.
DR   PANTHER; PTHR11987:SF30; ALPHA-2,8-SIALYLTRANSFERASE 8B; 1.
DR   Pfam; PF00777; Glyco_transf_29; 1.
DR   PIRSF; PIRSF005557; Sialyl_trans; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:BAF37192.1};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAF37192.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          54..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        160..310
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005557-2"
SQ   SEQUENCE   378 AA;  42618 MW;  69FF21BD4A7B17C8 CRC64;
     MQLELRTLMF GIVTLLVIFL IIADIAEVQE EIGNIGGSRT LYLHSLIPKP NRNVAVKANP
     TPLGNEGEEK SPASPSGLKN ATRLSSDNWT FNRTLSSLIR KNILGFFDPE RDISILKGTL
     KPGDVIHYVF DRQSTTNISE NLYQLLPTAS PMKNQHHRSC AIVGNSGIQL NSSCGPEIDS
     HDFVIRCNLA PVEEYAGDVG RRTNLVTMNP SVVQRAFHDL ASEQWRERFL QRLRGLSGSV
     LWIPAFMAKG GEERVEWAIR LILLHTVDVH TAFPSLRLLH AVRGYWLTNN VQIKRPTTGL
     LMYTMATRFC EEIHLYGFWP FPQDSQGKPV KYHYYDTLTY EYTSHASPHT MPLEFRTLSS
     LHRQGALRLN TGSCDVGT
//