ID NR6A1_PIG Reviewed; 479 AA. AC A0P8Z4; DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot. DT 13-NOV-2007, sequence version 2. DT 08-NOV-2023, entry version 93. DE RecName: Full=Nuclear receptor subfamily 6 group A member 1; DE AltName: Full=Germ cell nuclear factor; DE Short=GCNF; GN Name=NR6A1; Synonyms=GCNF; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LEU-192, CHARACTERIZATION RP OF VARIANT LEU-192, AND INTERACTION WITH UIMC1. RC STRAIN=Large white X Landrace X Duroc; RX PubMed=17416745; DOI=10.1101/gr.6085507; RA Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., RA Okumura N., Awata T.; RT "Fine mapping of a swine quantitative trait locus for number of vertebrae RT and analysis of an orphan nuclear receptor, germ cell nuclear factor RT (NR6A1)."; RL Genome Res. 17:586-593(2007). CC -!- FUNCTION: Orphan nuclear receptor. Binds to a response element CC containing the sequence 5'-TCAAGGTCA-3'. May be involved in the CC regulation of gene expression in germ cell development during CC gametogenesis (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Homodimer. Interacts with UIMC1 (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- POLYMORPHISM: The polymorphism in position 192 seems to be responsible CC for the increase in number of vertebrae in domestic pigs. Wild boars CC uniformly have 19 vertebrae, while European commercial breeds have 21 CC to 23 vertebrae The ancestral form with Leu-192 has a 3 times lower CC binding activity to UIMC1 than Pro-192. The binding to NCOR1 is twice CC lower with Leu-192 than with Pro-192. {ECO:0000269|PubMed:17416745}. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR6 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB248749; BAF37829.1; -; mRNA. DR EMBL; AP009124; BAF45332.1; -; Genomic_DNA. DR RefSeq; NP_001090968.1; NM_001097499.1. DR AlphaFoldDB; A0P8Z4; -. DR SMR; A0P8Z4; -. DR BioGRID; 1151537; 2. DR STRING; 9823.ENSSSCP00000005986; -. DR PaxDb; 9823-ENSSSCP00000005986; -. DR GeneID; 100038028; -. DR KEGG; ssc:100038028; -. DR CTD; 2649; -. DR eggNOG; KOG3575; Eukaryota. DR InParanoid; A0P8Z4; -. DR OrthoDB; 5397661at2759; -. DR Proteomes; UP000008227; Unplaced. DR Proteomes; UP000314985; Unplaced. DR Proteomes; UP000694570; Unplaced. DR Proteomes; UP000694571; Unplaced. DR Proteomes; UP000694720; Unplaced. DR Proteomes; UP000694722; Unplaced. DR Proteomes; UP000694723; Unplaced. DR Proteomes; UP000694724; Unplaced. DR Proteomes; UP000694725; Unplaced. DR Proteomes; UP000694726; Unplaced. DR Proteomes; UP000694727; Unplaced. DR Proteomes; UP000694728; Unplaced. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0034056; F:estrogen response element binding; IBA:GO_Central. DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. DR CDD; cd07169; NR_DBD_GCNF_like; 1. DR CDD; cd06953; NR_LBD_DHR4_like; 1. DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1. DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1. DR InterPro; IPR035500; NHR-like_dom_sf. DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd. DR InterPro; IPR001723; Nuclear_hrmn_rcpt. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR48092; KNIRPS-RELATED PROTEIN-RELATED; 1. DR PANTHER; PTHR48092:SF18; NUCLEAR RECEPTOR SUBFAMILY 6 GROUP A MEMBER 1; 1. DR Pfam; PF00104; Hormone_recep; 1. DR Pfam; PF00105; zf-C4; 1. DR PRINTS; PR00398; STRDHORMONER. DR PRINTS; PR00047; STROIDFINGER. DR SMART; SM00430; HOLI; 1. DR SMART; SM00399; ZnF_C4; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1. DR PROSITE; PS51843; NR_LBD; 1. DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 1: Evidence at protein level; KW Developmental protein; Differentiation; DNA-binding; Metal-binding; KW Nucleus; Receptor; Reference proteome; Spermatogenesis; Transcription; KW Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..479 FT /note="Nuclear receptor subfamily 6 group A member 1" FT /id="PRO_0000311223" FT DOMAIN 248..479 FT /note="NR LBD" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189" FT DNA_BIND 57..132 FT /note="Nuclear receptor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT ZN_FING 60..80 FT /note="NR C4-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT ZN_FING 96..120 FT /note="NR C4-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 131..150 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 162..198 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 172..252 FT /note="Sufficient for interaction with UIMC1" FT /evidence="ECO:0000250" FT COMPBIAS 173..198 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 192 FT /note="P -> L (may be associated with an increase in number FT of vertebrae in European domestic breds)" FT /evidence="ECO:0000269|PubMed:17416745" SQ SEQUENCE 479 AA; 54350 MW; 00CD8ED7F8F40D4A CRC64; MERDERPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPSTISV PDDRAEQRTC LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK NCVMSRKQRN RCQYCRLLKC LQMGMNRKAI REDGMPGGRN KSIGPVQISE EEIERIMSGQ EFEEEANHWS NHGDSDHSSP GNRASESNQP SPGSTLSSRS VELNGFMAFR DQYMGMSVPP HYQYIPHLFS YSAHSPLLPP QARSLDPQSY SLIHQLVSAE DLEPLGTPML IEDGYAVTQA ELFALLCRLA DELLFRQIAW IKKLPFFCEL SIKDYTCLLS STWQELILLS SLTVYSKQIF GELADVTAKY SPSDEELHRF SDEGMEVIER LIYLYHKFHQ LKVSNEEYAC MKAINFLNQD IRGLTSASQL EQLNKRYWYI CQDFTEYKYT HQPNRFPDLM MCLPEIRYIA GKMVNVPLEQ LPLLFKVVLH SCKTSVGKE //