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A0P8Z4

- NR6A1_PIG

UniProt

A0P8Z4 - NR6A1_PIG

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Protein
Nuclear receptor subfamily 6 group A member 1
Gene
NR6A1, GCNF
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi57 – 13276Nuclear receptor
Add
BLAST
Zinc fingeri60 – 8021NR C4-type
Add
BLAST
Zinc fingeri96 – 12025NR C4-type
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 6 group A member 1
Alternative name(s):
Germ cell nuclear factor
Short name:
GCNF
Gene namesi
Name:NR6A1
Synonyms:GCNF
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Nuclear receptor subfamily 6 group A member 1
PRO_0000311223Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with UIMC1 By similarity.1 Publication

Protein-protein interaction databases

BioGridi1151537. 2 interactions.
STRINGi9823.ENSSSCP00000005985.

Structurei

3D structure databases

ProteinModelPortaliA0P8Z4.
SMRiA0P8Z4. Positions 60-125.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 25281Sufficient for interaction with UIMC1 By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG253308.
HOGENOMiHOG000113847.
HOVERGENiHBG052664.
KOiK08561.

Family and domain databases

Gene3Di1.10.565.10. 4 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 2 hits.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0P8Z4-1 [UniParc]FASTAAdd to Basket

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MERDERPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPSTISV    50
PDDRAEQRTC LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK 100
NCVMSRKQRN RCQYCRLLKC LQMGMNRKAI REDGMPGGRN KSIGPVQISE 150
EEIERIMSGQ EFEEEANHWS NHGDSDHSSP GNRASESNQP SPGSTLSSRS 200
VELNGFMAFR DQYMGMSVPP HYQYIPHLFS YSAHSPLLPP QARSLDPQSY 250
SLIHQLVSAE DLEPLGTPML IEDGYAVTQA ELFALLCRLA DELLFRQIAW 300
IKKLPFFCEL SIKDYTCLLS STWQELILLS SLTVYSKQIF GELADVTAKY 350
SPSDEELHRF SDEGMEVIER LIYLYHKFHQ LKVSNEEYAC MKAINFLNQD 400
IRGLTSASQL EQLNKRYWYI CQDFTEYKYT HQPNRFPDLM MCLPEIRYIA 450
GKMVNVPLEQ LPLLFKVVLH SCKTSVGKE 479
Length:479
Mass (Da):54,350
Last modified:November 13, 2007 - v2
Checksum:i00CD8ED7F8F40D4A
GO

Polymorphismi

The polymorphism in position 192 seems to be responsible for the increase in number of vertebrae in domestic pigs. Wild boars uniformly have 19 vertebrae, while European commercial breeds have 21 to 23 vertebrae The ancestral form with Leu-192 has a 3 times lower binding activity to UIMC1 than Pro-192. The binding to NCOR1 is twice lower with Leu-192 than with Pro-192.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921P → L Polymorphism responsible for increase of vertebrae in European domestic breds. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB248749 mRNA. Translation: BAF37829.1.
AP009124 Genomic DNA. Translation: BAF45332.1.
RefSeqiNP_001090968.1. NM_001097499.1.
UniGeneiSsc.51714.

Genome annotation databases

GeneIDi100038028.
KEGGissc:100038028.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB248749 mRNA. Translation: BAF37829.1 .
AP009124 Genomic DNA. Translation: BAF45332.1 .
RefSeqi NP_001090968.1. NM_001097499.1.
UniGenei Ssc.51714.

3D structure databases

ProteinModelPortali A0P8Z4.
SMRi A0P8Z4. Positions 60-125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1151537. 2 interactions.
STRINGi 9823.ENSSSCP00000005985.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100038028.
KEGGi ssc:100038028.

Organism-specific databases

CTDi 2649.

Phylogenomic databases

eggNOGi NOG253308.
HOGENOMi HOG000113847.
HOVERGENi HBG052664.
KOi K08561.

Family and domain databases

Gene3Di 1.10.565.10. 4 hits.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 2 hits.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)."
    Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., Okumura N., Awata T.
    Genome Res. 17:586-593(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LEU-192, CHARACTERIZATION OF VARIANT LEU-192, INTERACTION WITH UIMC1.
    Strain: Large white X Landrace X Duroc.

Entry informationi

Entry nameiNR6A1_PIG
AccessioniPrimary (citable) accession number: A0P8Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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