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A0P8Z4

- NR6A1_PIG

UniProt

A0P8Z4 - NR6A1_PIG

Protein

Nuclear receptor subfamily 6 group A member 1

Gene

NR6A1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi57 – 13276Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri60 – 8021NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri96 – 12025NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. steroid hormone receptor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. spermatogenesis Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Differentiation, Spermatogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor subfamily 6 group A member 1
    Alternative name(s):
    Germ cell nuclear factor
    Short name:
    GCNF
    Gene namesi
    Name:NR6A1
    Synonyms:GCNF
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Nuclear receptor subfamily 6 group A member 1PRO_0000311223Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with UIMC1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi1151537. 2 interactions.
    STRINGi9823.ENSSSCP00000005985.

    Structurei

    3D structure databases

    ProteinModelPortaliA0P8Z4.
    SMRiA0P8Z4. Positions 60-125.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni172 – 25281Sufficient for interaction with UIMC1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri60 – 8021NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri96 – 12025NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG253308.
    HOGENOMiHOG000113847.
    HOVERGENiHBG052664.
    KOiK08561.

    Family and domain databases

    Gene3Di1.10.565.10. 4 hits.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 2 hits.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A0P8Z4-1 [UniParc]FASTAAdd to Basket

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    MERDERPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPSTISV    50
    PDDRAEQRTC LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK 100
    NCVMSRKQRN RCQYCRLLKC LQMGMNRKAI REDGMPGGRN KSIGPVQISE 150
    EEIERIMSGQ EFEEEANHWS NHGDSDHSSP GNRASESNQP SPGSTLSSRS 200
    VELNGFMAFR DQYMGMSVPP HYQYIPHLFS YSAHSPLLPP QARSLDPQSY 250
    SLIHQLVSAE DLEPLGTPML IEDGYAVTQA ELFALLCRLA DELLFRQIAW 300
    IKKLPFFCEL SIKDYTCLLS STWQELILLS SLTVYSKQIF GELADVTAKY 350
    SPSDEELHRF SDEGMEVIER LIYLYHKFHQ LKVSNEEYAC MKAINFLNQD 400
    IRGLTSASQL EQLNKRYWYI CQDFTEYKYT HQPNRFPDLM MCLPEIRYIA 450
    GKMVNVPLEQ LPLLFKVVLH SCKTSVGKE 479
    Length:479
    Mass (Da):54,350
    Last modified:November 13, 2007 - v2
    Checksum:i00CD8ED7F8F40D4A
    GO

    Polymorphismi

    The polymorphism in position 192 seems to be responsible for the increase in number of vertebrae in domestic pigs. Wild boars uniformly have 19 vertebrae, while European commercial breeds have 21 to 23 vertebrae The ancestral form with Leu-192 has a 3 times lower binding activity to UIMC1 than Pro-192. The binding to NCOR1 is twice lower with Leu-192 than with Pro-192.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti192 – 1921P → L Polymorphism responsible for increase of vertebrae in European domestic breds. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB248749 mRNA. Translation: BAF37829.1.
    AP009124 Genomic DNA. Translation: BAF45332.1.
    RefSeqiNP_001090968.1. NM_001097499.1.
    UniGeneiSsc.51714.

    Genome annotation databases

    GeneIDi100038028.
    KEGGissc:100038028.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB248749 mRNA. Translation: BAF37829.1 .
    AP009124 Genomic DNA. Translation: BAF45332.1 .
    RefSeqi NP_001090968.1. NM_001097499.1.
    UniGenei Ssc.51714.

    3D structure databases

    ProteinModelPortali A0P8Z4.
    SMRi A0P8Z4. Positions 60-125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 1151537. 2 interactions.
    STRINGi 9823.ENSSSCP00000005985.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100038028.
    KEGGi ssc:100038028.

    Organism-specific databases

    CTDi 2649.

    Phylogenomic databases

    eggNOGi NOG253308.
    HOGENOMi HOG000113847.
    HOVERGENi HBG052664.
    KOi K08561.

    Family and domain databases

    Gene3Di 1.10.565.10. 4 hits.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 2 hits.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)."
      Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., Okumura N., Awata T.
      Genome Res. 17:586-593(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LEU-192, CHARACTERIZATION OF VARIANT LEU-192, INTERACTION WITH UIMC1.
      Strain: Large white X Landrace X Duroc.

    Entry informationi

    Entry nameiNR6A1_PIG
    AccessioniPrimary (citable) accession number: A0P8Z4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3