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A0P8Z4 (NR6A1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nuclear receptor subfamily 6 group A member 1
Alternative name(s):
Germ cell nuclear factor
Short name=GCNF
Gene names
Name:NR6A1
Synonyms:GCNF
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis By similarity.

Subunit structure

Homodimer. Interacts with UIMC1 By similarity. Ref.1

Subcellular location

Nucleus Probable.

Polymorphism

The polymorphism in position 192 seems to be responsible for the increase in number of vertebrae in domestic pigs. Wild boars uniformly have 19 vertebrae, while European commercial breeds have 21 to 23 vertebrae The ancestral form with Leu-192 has a 3 times lower binding activity to UIMC1 than Pro-192. The binding to NCOR1 is twice lower with Leu-192 than with Pro-192.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR6 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Nuclear receptor subfamily 6 group A member 1
PRO_0000311223

Regions

DNA binding57 – 13276Nuclear receptor
Zinc finger60 – 8021NR C4-type
Zinc finger96 – 12025NR C4-type
Region172 – 25281Sufficient for interaction with UIMC1 By similarity

Natural variations

Natural variant1921P → L Polymorphism responsible for increase of vertebrae in European domestic breds. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A0P8Z4 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 00CD8ED7F8F40D4A

FASTA47954,350
        10         20         30         40         50         60 
MERDERPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPSTISV PDDRAEQRTC 

        70         80         90        100        110        120 
LICGDRATGL HYGIISCEGC KGFFKRSICN KRVYRCSRDK NCVMSRKQRN RCQYCRLLKC 

       130        140        150        160        170        180 
LQMGMNRKAI REDGMPGGRN KSIGPVQISE EEIERIMSGQ EFEEEANHWS NHGDSDHSSP 

       190        200        210        220        230        240 
GNRASESNQP SPGSTLSSRS VELNGFMAFR DQYMGMSVPP HYQYIPHLFS YSAHSPLLPP 

       250        260        270        280        290        300 
QARSLDPQSY SLIHQLVSAE DLEPLGTPML IEDGYAVTQA ELFALLCRLA DELLFRQIAW 

       310        320        330        340        350        360 
IKKLPFFCEL SIKDYTCLLS STWQELILLS SLTVYSKQIF GELADVTAKY SPSDEELHRF 

       370        380        390        400        410        420 
SDEGMEVIER LIYLYHKFHQ LKVSNEEYAC MKAINFLNQD IRGLTSASQL EQLNKRYWYI 

       430        440        450        460        470 
CQDFTEYKYT HQPNRFPDLM MCLPEIRYIA GKMVNVPLEQ LPLLFKVVLH SCKTSVGKE 

« Hide

References

[1]"Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)."
Mikawa S., Morozumi T., Shimanuki S., Hayashi T., Uenishi H., Domukai M., Okumura N., Awata T.
Genome Res. 17:586-593(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LEU-192, CHARACTERIZATION OF VARIANT LEU-192, INTERACTION WITH UIMC1.
Strain: Large white X Landrace X Duroc.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB248749 mRNA. Translation: BAF37829.1.
AP009124 Genomic DNA. Translation: BAF45332.1.
RefSeqNP_001090968.1. NM_001097499.1.
UniGeneSsc.51714.

3D structure databases

ProteinModelPortalA0P8Z4.
SMRA0P8Z4. Positions 60-125.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1151537. 2 interactions.
STRING9823.ENSSSCP00000005985.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100038028.
KEGGssc:100038028.

Organism-specific databases

CTD2649.

Phylogenomic databases

eggNOGNOG253308.
HOGENOMHOG000113847.
HOVERGENHBG052664.
KOK08561.

Family and domain databases

Gene3D1.10.565.10. 4 hits.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 2 hits.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNR6A1_PIG
AccessionPrimary (citable) accession number: A0P8Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families