ANCE5

Functionⁱ

Cofactorⁱ

Zn²⁺UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functionⁱ

carboxypeptidase activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
metallopeptidase activity Source: UniProtKB-KW
peptidyl-dipeptidase activity Source: InterPro

Keywordsⁱ

Molecular function	CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
Ligand	Metal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M02.003.

MEROPSⁱ

M02.003.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
Gene namesⁱ	Name:ANCE5Imported ORF Names:AgaP_AGAP009755Imported
Organismⁱ	Anopheles gambiae (African malaria mosquito)Imported
Taxonomic identifierⁱ	7165 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicoidea › Culicidae › Anophelinae › Anopheles › Cellia › Pyretophorus › gambiae species complex
Proteomesⁱ	UP000007062 Componentⁱ: Chromosome 3R

Subcellular locationⁱ

GO - Cellular componentⁱ

membrane Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_5010490719	20 – 620	Angiotensin-converting enzymeSequence analysisAdd BLAST		601

Keywords - PTMⁱ

GlycoproteinUniRule annotation

Proteomic databases

PaxDbⁱ	A0NFV2.

PaxDbⁱ

A0NFV2.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	7165.AGAP009755-PA.

STRINGⁱ

7165.AGAP009755-PA.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A0NFV2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3690. Eukaryota. ENOG410XPJ3. LUCA.
HOGENOMⁱ	HOG000292210.
InParanoidⁱ	A0NFV2.
KEGG Orthology (KO) More...KOⁱ	K01283.
OMAⁱ	GPCLPLE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G033S.
PhylomeDBⁱ	A0NFV2.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06461. M2_ACE. 1 hit.
InterProⁱ	View protein in InterPro IPR001548. Peptidase_M2.
PANTHERⁱ	PTHR10514. PTHR10514. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01401. Peptidase_M2. 1 hit.
PRINTSⁱ	PR00791. PEPDIPTASEA.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0NFV2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRIFSTVIIA FALVCCVLGG KLVSVSDDEL EARHYVEQVD EEILSRRNVG 
        60         70         80         90        100
TEAEWAYESD INEDNLMVKN EVAAANAMFL KEVANTLNKY EYESFSDEDL 
       110        120        130        140        150
KRKIRKLTKL GYSVLPEDTF AEMLDAINRM QENYAKVKVC DYRDNSKCDL 
       160        170        180        190        200
ALEPELTEIM ATSRDPEELK YYWQQWYDAA GAPTRDDFQK YVDLNGVAAR 
       210        220        230        240        250
MNNYSSGAEY WLSAYEDDTF EEQVDAVIEE LRPLYEQIHA NVRYQLRKYY 
       260        270        280        290        300
GEDVVSEKGP IPMHLLGNMW AQDWAGVADI ISPFPDRQLL DVTEEMVRQG 
       310        320        330        340        350
YNPIQMFEMG DEFFQSMNMT KLPATFWEKS ILEKPDDGRD LVCHASAWEF 
       360        370        380        390        400
SKTDDVRIKQ CTRVTMEQFF TVHHELGHVQ YFLQYQHLPS MYRDGANPGF 
       410        420        430        440        450
HEAVGDVLSL SVSTPKHLEK IGLLKDYVED EESKLNQFYG SALNKLVFLP 
       460        470        480        490        500
FAYTLDKYRW GIFRGDIKPE EYNCKFWEMR SKFSGVEPPV VRSESDLDAP 
       510        520        530        540        550
AKYHVSADVE YLRYFVSFII QFQFHRAACE KAGEYVKGDP EKTLNNCDIY 
       560        570        580        590        600
QSVEAGNAIK AMLELGSSKP WPDAMEVLTG ERRMSADALI EYFQPLYDWL 
       610        620
VVENERIGAH VGWEETESKF

Length:620

Mass (Da):71,777

Last modified:January 9, 2007 - v1

Checksum:ⁱ5BD0EC4CE0FBA8B7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAAB01008980 Genomic DNA. Translation: EAU76041.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001238057.1. XM_001238056.1.

Genome annotation databases

EnsemblMetazoaⁱ	AGAP009755-RA; AGAP009755-PA; AGAP009755.
GeneIDⁱ	4578342.
KEGGⁱ	aga:AgaP_AGAP009755.
VectorBaseⁱ	AGAP009755-RA; AGAP009755-PA; AGAP009755.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AAAB01008980 Genomic DNA. Translation: EAU76041.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_001238057.1. XM_001238056.1.

3D structure databases

ProteinModelPortalⁱ	A0NFV2.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	7165.AGAP009755-PA.

STRINGⁱ

7165.AGAP009755-PA.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	M02.003.

MEROPSⁱ

M02.003.

Proteomic databases

PaxDbⁱ	A0NFV2.

PaxDbⁱ

A0NFV2.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	AGAP009755-RA; AGAP009755-PA; AGAP009755.
GeneIDⁱ	4578342.
KEGGⁱ	aga:AgaP_AGAP009755.
VectorBaseⁱ	AGAP009755-RA; AGAP009755-PA; AGAP009755.

Organism-specific databases

CTDⁱ	4578342.

CTDⁱ

4578342.

Phylogenomic databases

eggNOGⁱ	KOG3690. Eukaryota. ENOG410XPJ3. LUCA.
HOGENOMⁱ	HOG000292210.
InParanoidⁱ	A0NFV2.
KEGG Orthology (KO) More...KOⁱ	K01283.
OMAⁱ	GPCLPLE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G033S.
PhylomeDBⁱ	A0NFV2.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06461. M2_ACE. 1 hit.
InterProⁱ	View protein in InterPro IPR001548. Peptidase_M2.
PANTHERⁱ	PTHR10514. PTHR10514. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01401. Peptidase_M2. 1 hit.
PRINTSⁱ	PR00791. PEPDIPTASEA.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0NFV2_ANOGA
Accessionⁱ	A0NFV2Primary (citable) accession number: A0NFV2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	January 9, 2007
	Last sequence update:	January 9, 2007
	Last modified:	July 5, 2017
	This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0NFV2 (A0NFV2_ANOGA)

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Angiotensin-converting enzyme

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ