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Protein

Angiotensin-converting enzyme

Gene

ANCE4

Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Protein family/group databases

MEROPSiM02.003

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
Gene namesi
Name:ANCE4Imported
Synonyms:4578145Imported
ORF Names:AgaP_AGAP009754Imported
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componenti: Chromosome 3R

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501429669421 – 624Angiotensin-converting enzymeSequence analysisAdd BLAST604

Keywords - PTMi

GlycoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP009754-PA

Structurei

3D structure databases

ProteinModelPortaliA0NFV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3690 Eukaryota
ENOG410XPJ3 LUCA
HOGENOMiHOG000292210
InParanoidiA0NFV1
KOiK01283
OMAiKTTHHEM
OrthoDBiEOG091G033S
PhylomeDBiA0NFV1

Family and domain databases

CDDicd06461 M2_ACE, 1 hit
InterProiView protein in InterPro
IPR001548 Peptidase_M2
PANTHERiPTHR10514 PTHR10514, 1 hit
PfamiView protein in Pfam
PF01401 Peptidase_M2, 1 hit
PRINTSiPR00791 PEPDIPTASEA

Sequencei

Sequence statusi: Complete.

A0NFV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVLLVSLA IGLVCHVSTA RIPRRVLQAQ EEEVFQYLED IEPEILARRN
60 70 80 90 100
AASEANWAYD SNITDDNLDV KNEVATENAA FFKQISEYLS QFEYESFENE
110 120 130 140 150
NLKRRVKKLV GLGYSALPEE KFTEMLDAIN NMKENYAKIK VCDYHDRSKC
160 170 180 190 200
DLALEPELTE ILANSRDAEE LKYYWQQWYD AAGTPTREDF QTYVELNGEA
210 220 230 240 250
AKLNNYESGA DSWLSAYEDD TFEEQVDAVI EELRPFYEQI HAYVRYRLRE
260 270 280 290 300
FYGEDVVSEK GPIPMHLLGN MWAQGWENIA EITSPFGDRE MFDVTEEMVR
310 320 330 340 350
QGYTPVQMFE MGDEFFQSLN MTKLPQTFWE KSILEKPDDG RDLICHASAW
360 370 380 390 400
DFSKPDDVRI KQCTRVTMDQ FFTAHHELGH IQYYLQYQHQ PSVYRSGANP
410 420 430 440 450
GFHEAVGDVL SLSVSTPKHL EKIGLLKDYV QDEESKLNQF YQAGLSKLVF
460 470 480 490 500
LPFAYTLDKY RWGIFRGDIK PEEYNCKFWE MRSKYSGIEP PVVRTEADFD
510 520 530 540 550
APAKYHVSAD VEYLRYFVSY IIQFQFHRAA CEKAGEYVKG DPEKTLNDCD
560 570 580 590 600
IYQSTEAGNA IKAMLELGSS KPWPDAMEVL TGERRMSADA LIEYFQPLYD
610 620
WLVVENERIG AHVGWEETDS KCEV
Length:624
Mass (Da):72,474
Last modified:October 23, 2007 - v2
Checksum:i2E98A4E89F205DFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAB01008980 Genomic DNA Translation: EAU76040.2
RefSeqiXP_001238056.2, XM_001238055.2

Genome annotation databases

EnsemblMetazoaiAGAP009754-RA; AGAP009754-PA; AGAP009754
GeneIDi4578145
KEGGiaga:AgaP_AGAP009754
VectorBaseiAGAP009754-RA; AGAP009754-PA; AGAP009754

Similar proteinsi

Entry informationi

Entry nameiA0NFV1_ANOGA
AccessioniPrimary (citable) accession number: A0NFV1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2007
Last sequence update: October 23, 2007
Last modified: April 25, 2018
This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health