Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome P450

Gene

CYP1A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:CYP1A1Imported
ORF Names:hCG_40803Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, MicrosomeUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27092.

Expressioni

Gene expression databases

BgeeiENSG00000140465.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369050.

Structurei

3D structure databases

SMRiA0N0X8. Positions 36-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG106944.
KOiK07408.
OMAiRYDHNHQ.
OrthoDBiEOG091G0BT8.
PhylomeDBiA0N0X8.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0N0X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFPISMSAT EFLLASVIFC LVFWVIRASR PQVPKGLKNP PGPWGWPLIG
60 70 80 90 100
HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVVVLSGLD TIRQALVRQG
110 120 130 140 150
DDFKGRPDLY TFTLISNGQS MSFSPDSGPV WAARRRLAQN GLKSFSIASD
160 170 180 190 200
PASSTSCYLE EHVSKEAEVL ISTLQELMAG PGHFNPYRYV VVSVTNVICA
210 220 230 240 250
ICFGRRYDHN HQELLSLVNL NNNFGEVVGS GNPADFIPIL RYLPNPSLNA
260 270 280 290 300
FKDLNEKFYS FMQKMVKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANV
310 320 330 340 350
QLSDEKIINI VLDLFGAGFD TVTTAISWSL MYLVMNPRVQ RKIQEELDTV
360 370 380 390 400
IGRSRRPRLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY
410 420 430 440 450
IPKGRCVFVN QWQINHDQKL WVNPSEFLPE RFLTPDGAID KVLSEKVIIF
460 470 480 490 500
GMGKRKCIGE TIARWEVFLF LAILLQRVEF SVPLGVKVDM TPIYGLTMKH
510
ACCEHFQMQL RS
Length:512
Mass (Da):58,165
Last modified:December 12, 2006 - v1
Checksum:i3C62366044148EFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF094025 Genomic DNA. Translation: ABK41999.1.
AK313880 mRNA. Translation: BAG36606.1.
CH471136 Genomic DNA. Translation: EAW99314.1.
CH471136 Genomic DNA. Translation: EAW99315.1.
RefSeqiNP_000490.1. NM_000499.4.
NP_001306146.1. NM_001319217.1.
UniGeneiHs.72912.

Genome annotation databases

GeneIDi1543.
KEGGihsa:1543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF094025 Genomic DNA. Translation: ABK41999.1.
AK313880 mRNA. Translation: BAG36606.1.
CH471136 Genomic DNA. Translation: EAW99314.1.
CH471136 Genomic DNA. Translation: EAW99315.1.
RefSeqiNP_000490.1. NM_000499.4.
NP_001306146.1. NM_001319217.1.
UniGeneiHs.72912.

3D structure databases

SMRiA0N0X8. Positions 36-512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369050.

Protocols and materials databases

DNASUi1543.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1543.
KEGGihsa:1543.

Organism-specific databases

CTDi1543.
PharmGKBiPA27092.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG106944.
KOiK07408.
OMAiRYDHNHQ.
OrthoDBiEOG091G0BT8.
PhylomeDBiA0N0X8.

Miscellaneous databases

ChiTaRSiCYP1A1. human.
GenomeRNAii1543.

Gene expression databases

BgeeiENSG00000140465.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0N0X8_HUMAN
AccessioniPrimary (citable) accession number: A0N0X8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.