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Protein
Submitted name:

Chemokine (C-C motif) receptor 7

Gene

CCR7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Chemokine (C-C motif) receptor 7Imported
Submitted name:
cDNA FLJ45911 fis, clone PEBLM2005615, highly similar to C-C chemokine receptor type 7Imported
Gene namesi
Name:CCR7Imported
ORF Names:hCG_1643840Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 84HelicalSequence analysisAdd BLAST26
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei122 – 150HelicalSequence analysisAdd BLAST29
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei225 – 249HelicalSequence analysisAdd BLAST25
Transmembranei261 – 279HelicalSequence analysisAdd BLAST19
Transmembranei310 – 329HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500875391225 – 378Sequence analysisAdd BLAST354

Expressioni

Gene expression databases

BgeeiENSG00000126353.
ExpressionAtlasiA0N0Q0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000246657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 326G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST252

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
HOVERGENiHBG106917.
KOiK04182.
OMAiVMLTYIY.
OrthoDBiEOG091G0BDV.
PhylomeDBiA0N0Q0.

Family and domain databases

InterProiView protein in InterPro
IPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0N0Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK
60 70 80 90 100
KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL
110 120 130 140 150
AVADILFLLT LPFWAYSAAK SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI
160 170 180 190 200
SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV GIWILATVLS IPELLYSDLQ
210 220 230 240 250
RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS FCYLVIIRTL
260 270 280 290 300
LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL
310 320 330 340 350
SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE
360 370
QLRQWSSCRH IRRSSMSVEA ETTTTFSP
Length:378
Mass (Da):42,874
Last modified:December 12, 2006 - v1
Checksum:iD4CB4213841A1BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064758 Genomic DNA. Translation: ABK41941.1.
AK127810 mRNA. Translation: BAG54575.1.
CH471152 Genomic DNA. Translation: EAW60669.1.
RefSeqiNP_001829.1. NM_001838.3.
UniGeneiHs.370036.

Genome annotation databases

GeneIDi1236.
KEGGihsa:1236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF064758 Genomic DNA. Translation: ABK41941.1.
AK127810 mRNA. Translation: BAG54575.1.
CH471152 Genomic DNA. Translation: EAW60669.1.
RefSeqiNP_001829.1. NM_001838.3.
UniGeneiHs.370036.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000246657.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

DNASUi1236.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1236.
KEGGihsa:1236.

Organism-specific databases

CTDi1236.
PharmGKBiPA26172.

Phylogenomic databases

eggNOGiENOG410IMBE. Eukaryota.
ENOG4110ZGY. LUCA.
HOVERGENiHBG106917.
KOiK04182.
OMAiVMLTYIY.
OrthoDBiEOG091G0BDV.
PhylomeDBiA0N0Q0.

Miscellaneous databases

GenomeRNAii1236.

Gene expression databases

BgeeiENSG00000126353.
ExpressionAtlasiA0N0Q0. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR001718. Chemokine_CCR7.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00657. CCCHEMOKINER.
PR00641. CHEMOKINER7.
PR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA0N0Q0_HUMAN
AccessioniPrimary (citable) accession number: A0N0Q0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: March 15, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.