A0N0Q0 (A0N0Q0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Chemokine (C-C motif) receptor 7 EMBL ABK41941.1

Submitted name:
cDNA FLJ45911 fis, clone PEBLM2005615, highly similar to C-C chemokine receptor type 7 EMBL BAG54575.1

Gene names

Name:	CCR7 EMBL ABK41941.1
ORF Names:	hCG_1643840 EMBL EAW60669.1

Organism

Homo sapiens (Human) EMBL ABK41941.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS000355
Molecular function	G-protein coupled receptor RuleBase RU000688 SAAS SAAS000355 Receptor Transducer
Gene Ontology (GO)
Biological_process	chemokine-mediated signaling pathway Inferred from electronic annotation. Source: GOC chemotaxis Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: Compara interleukin-12 secretion Inferred from electronic annotation. Source: Compara mature dendritic cell differentiation Inferred from electronic annotation. Source: Compara negative thymic T cell selection Inferred from electronic annotation. Source: Compara positive regulation of T cell costimulation Inferred from electronic annotation. Source: Compara positive regulation of T cell receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of dendritic cell antigen processing and presentation Inferred from electronic annotation. Source: Compara positive regulation of dendritic cell chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response Inferred from electronic annotation. Source: Compara positive regulation of hypersensitivity Inferred from electronic annotation. Source: Compara positive regulation of immunological synapse formation Inferred from electronic annotation. Source: Compara positive regulation of interleukin-12 production Inferred from electronic annotation. Source: Compara positive regulation of neutrophil chemotaxis Inferred from electronic annotation. Source: Compara regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara regulation of interleukin-1 beta secretion Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: Compara
Molecular_function	C-C chemokine receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A0N0Q0 [UniParc]. Last modified December 12, 2006. Version 1. Checksum: D4CB4213841A1BD4	FASTA	378	42,874
	10 20 30 40 50 60 MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF 70 80 90 100 110 120 LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK 130 140 150 160 170 180 SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 190 200 210 220 230 240 GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS 250 260 270 280 290 300 FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL 310 320 330 340 350 360 SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH 370 IRRSSMSVEA ETTTTFSP

References

[1]	"NEDO human cDNA sequencing project." Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., Arita M., Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y., Kawai-Hio Y. , Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Murakawa K., Kanehori K., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF064758 Genomic DNA. Translation: ABK41941.1. AK127810 mRNA. Translation: BAG54575.1. CH471152 Genomic DNA. Translation: EAW60669.1.
IPI	IPI00027687.
RefSeq	NP_001829.1. NM_001838.3.
UniGene	Hs.370036.
3D structure databases
ProteinModelPortal	A0N0Q0.
ModBase	Search...
Protein-protein interaction databases
STRING	A0N0Q0.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	A0N0Q0.
Protocols and materials databases
DNASU	1236.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1236.
KEGG	hsa:1236.
Organism-specific databases
CTD	1236.
PharmGKB	PA26172.
Phylogenomic databases
HOVERGEN	HBG106917.
KO	K04182.
OMA	CFKKDVR.
PhylomeDB	A0N0Q0.
Gene expression databases
ArrayExpress	A0N0Q0.
Bgee	A0N0Q0.
Family and domain databases
InterPro	IPR001718. Chemokine_CCR7. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR00641. CHEMOKINER7. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	A0N0Q0.
GenomeRNAi	1236.
NextBio	5049.

Entry information

Entry name

A0N0Q0_HUMAN

Accession

Primary (citable) accession number: A0N0Q0

Entry history

Integrated into UniProtKB/TrEMBL:	December 12, 2006
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.