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Protein
Submitted name:

Interleukin 6 receptor

Gene

IL6R

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 6 receptorImported
Submitted name:
Interleukin 6 receptor, isoform CRA_aImported
Gene namesi
Name:IL6RImported
ORF Names:hCG_1810911Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000160712.12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei367 – 388HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29835

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501429651920 – 468Sequence analysisAdd BLAST449

Expressioni

Gene expression databases

BgeeiENSG00000160712

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 96Ig-likeInterPro annotationAdd BLAST71
Domaini113 – 217Fibronectin type-IIIInterPro annotationAdd BLAST105
Domaini218 – 316Fibronectin type-IIIInterPro annotationAdd BLAST99

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410II5K Eukaryota
ENOG4111XGC LUCA
HOVERGENiHBG052118
KOiK05055
OrthoDBiEOG091G07XD

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.103 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF09240 IL6Ra-bind, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

A0N0L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV
60 70 80 90 100
EPEDNATVHW VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG
110 120 130 140 150
RPAGTVHLLV DVPPEEPQLS CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV
160 170 180 190 200
RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS
210 220 230 240 250
KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR
260 270 280 290 300
LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ
310 320 330 340 350
GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN
360 370 380 390 400
ATSLPVQDSS SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG
410 420 430 440 450
KTSMHPPYSL GQLVPERPRP TPVLVPLISP PVSPSSLGSD NTSSHNRPDA
460
RDPRSPYDIS NTDYFFPR
Length:468
Mass (Da):51,548
Last modified:December 12, 2006 - v1
Checksum:i62AA239FA14F1B8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC132684 mRNA Translation: AAI32685.1
BC132686 mRNA Translation: AAI32687.1
EF064723 Genomic DNA Translation: ABK41906.1
CH471121 Genomic DNA Translation: EAW53199.1
RefSeqiNP_000556.1, NM_000565.3
UniGeneiHs.135087

Genome annotation databases

GeneIDi3570
KEGGihsa:3570

Similar proteinsi

Entry informationi

Entry nameiA0N0L5_HUMAN
AccessioniPrimary (citable) accession number: A0N0L5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 12, 2006
Last sequence update: December 12, 2006
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.